Search Results - "Ahnen, DJ"

Histamine receptor antagonists and incident colorectal adenomas by ROBERTSON, D. J., BURKE, C. A., SCHWENDER, B. J., WARGOVICH, M. J., GREENBERG, E. R., SANDLER, R. S., AHNEN, D. J., ROTHSTEIN, R., MOTT, L. A., BARON, J. A.

“…Summary Background:  Prior studies suggest that histamines may modulate the development of colorectal neoplasia. Aim:  To assess whether histamine receptor…”
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Folic Acid for the Prevention of Colorectal Adenomas: A Randomized Clinical Trial by Cole, Bernard F, Baron, John A, Sandler, Robert S, Haile, Robert W, Ahnen, Dennis J, Bresalier, Robert S, McKeown-Eyssen, Gail, Summers, Robert W, Rothstein, Richard I, Burke, Carol A, Snover, Dale C, Church, Timothy R, Allen, John I, Robertson, Douglas J, Beck, Gerald J, Bond, John H, Byers, Tim, Mandel, Jack S, Mott, Leila A, Pearson, Loretta H, Barry, Elizabeth L, Rees, Judy R, Marcon, Norman, Saibil, Fred, Ueland, Per Magne, Greenberg, E. Robert, Polyp Prevention Study Group, for the

“…CONTEXT Laboratory and epidemiological data suggest that folic acid may have an antineoplastic effect in the large intestine. OBJECTIVE To assess the safety…”
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Predictors of Nonadherence to Screening Colonoscopy by Denberg, Thomas D., Melhado, Trisha V., Coombes, John M., Beaty, Brenda L., Berman, Kenneth, Byers, Tim E., Marcus, Alfred C., Steiner, John F., Ahnen, Dennis J.

“…Background: Colonoscopy has become a preferred colorectal cancer (CRC) screening modality. Little is known about why patients who are referred for colonoscopy…”
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Use of Colonoscopy to Screen Asymptomatic Adults for Colorectal Cancer by Lieberman, David A, Weiss, David G, Bond, John H, Ahnen, Dennis J, Garewal, Harinder, Harford, William V, Provenzale, Dawn, Sontag, Steve, Schnell, Tom, Durbin, Theodore E, Nelson, Doug B, Ewing, Steve L, Triadafilopoulos, George, Ramirez, Francisco C, Lee, John G, Collins, Judith F, Fennerty, M. Brian, Johnston, Tiina K, Corless, Christopher L, McQuaid, Kenneth R, Sampliner, Richard E, Morales, Thomas G, Fass, Ronnie, Smith, Robert, Maheshwari, Yogesh, Chejfec, Gregorio

“…Colorectal cancer is the second leading cause of death in North America. There is evidence that the rate of mortality from colorectal cancer can be reduced by…”
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One-Time Screening for Colorectal Cancer with Combined Fecal Occult-Blood Testing and Examination of the Distal Colon by Lieberman, David A, Harford, William V, Ahnen, Dennis J, Provenzale, Dawn, Sontag, Stephen J, Schnell, Thomas G, Chejfec, Gregorio, Campbell, Donald R, Durbin, Theodore E, Bond, John H, Nelson, Douglas B, Ewing, Stephen L, Triadafilopoulos, George, Ramirez, Francisco C, Lee, John G, Collins, Judith F, Fennerty, M. Brian, Johnston, Tiina K, Corless, Christopher L, McQuaid, Kenneth R, Garewal, Harinder, Sampliner, Richard E, Morales, Thomas G, Fass, Ronnie, Smith, Robert E, Maheshwari, Yogesh, Weiss, David G

“…Occult-blood testing and sigmoidoscopy fails to identify about 25 percent of patients with colonic neoplasia. Screening of populations who are over 50 years of…”
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Randomized, Placebo-Controlled, Esophageal Squamous Cell Cancer Chemoprevention Trial of Selenomethionine and Celecoxib by Limburg, Paul J., Wei, Wenqiang, Ahnen, Dennis J., Qiao, Youlin, Hawk, Ernest T., Wang, Guoqing, Giffen, Carol A., Wang, Guiqi, Roth, Mark J., Lu, Ning, Korn, Edward L., Ma, Yurong, Caldwell, Kathleen L., Dong, Zheiwei, Taylor, Philip R., Dawsey, Sanford M.

“…Background & Aims: Esophageal squamous cell carcinoma remains a leading cause of cancer death worldwide. Squamous dysplasia, the accepted histological…”
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Measures for ascertaining use of colorectal cancer screening in behavioral, health services, and epidemiologic research by Vernon, Sally W, Meissner, Helen, Klabunde, Carrie, Rimer, Barbara K, Ahnen, Dennis J, Bastani, Roshan, Mandelson, Margaret T, Nadel, Marion R, Sheinfeld-Gorin, Sherri, Zapka, Jane

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Sulindac metabolites induce caspase- and proteasome-dependent degradation of β-catenin protein in human colon cancer cells by Rice, Pamela L, Kelloff, Jennifer, Sullivan, Holly, Driggers, Linda J, Beard, K Scott, Kuwada, Scott, Piazza, Gary, Ahnen, Dennis J

“…Colorectal cancer (CRC) is the second leading cause of cancer death in the USA. Accumulation of β-catenin protein is nearly ubiquitous in colon adenomas and…”
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Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer : A Southwest Oncology Group Study by AHNEN, D. J, FEIGL, P, GANG QUAN, FENOGLIO-PREISER, C, LOVATO, L. C, BUNN, P. A, STEMMERMAN, G, WELLS, J. D, MACDONALD, J. S, MEYSKENS, F. L

“…We assessed Ki-ras mutations by single-strand conformation polymorphism followed by DNA sequencing, p53 expression by immunohistochemistry, ploidy status, and…”
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Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction by PIAZZA, G. A, RAHM, A. K, FINN, T. S, FRYER, B. H, LI, H, STOUMEN, A. L, PAMUKCU, R, AHNEN, D. J

“…Sulindac causes regression of and prevents recurrence of colonic adenomas in patients with familial adenomatous polyposis. Although cell cycle arrest and…”
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Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels by PIAZZA, G. A, ALBERTS, D. S, SPERL, G, RITCHIE, J, BURT, R. W, ELLSWORTH, L, AHNEN, D. J, PAMUKCU, R, HIXSON, L. J, PARANKA, N. S, LI, H, FINN, T, BOGERT, C, GUILLEN, J. M, BRENDEL, K, GROSS, P. H

“…Nonsteroidal anti-inflammatory drugs (NSAIDs), such as sulindac, have cancer chemopreventive properties by a mechanism that has been suggested to involve…”
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Expression of β-catenin and full-length APC protein in normal and neoplastic colonic tissues by Iwamoto, Michiko, Ahnen, Dennis J, Franklin, Wilbur A., Maltzman, Terese H.

“…Mutations of the APC gene are thought to be early events in the process of colorectal carcinogenesis. Although the complete function(s) of the APC gene product…”
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Inhibition of extracellular signal-regulated kinase 1/2 phosphorylation and induction of apoptosis by sulindac metabolites by RICE, Pamela L, GOLDBERG, Ryan J, RAY, Evan C, DRIGGERS, Linda J, AHNEN, Dennis J

“…Regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and sulindac is associated with a decreased mortality from colorectal cancer…”
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Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis by PIAZZA, G. A, KULCHAK RAHM, A. L, AHNEN, D. J, KRUTZSCH, M, SPERL, G, PARANKA, N. S, GROSS, P. H, BRENDEL, K, BURT, R. W, ALBERTS, D. S, PAMUKCU, R

“…The nonsteroidal anti-inflammatory drug sulindac is known to inhibit chemical carcinogenesis in rodent models and cause regression of adenomas in patients with…”
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Inhibition of extracellular-signal regulated kinases 1/2 is required for apoptosis of human colon cancer cells in vitro by sulindac metabolites by RICE, Pamela L, BEARD, K. Scott, DRIGGERS, Linda J, AHNEN, Dennis J

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) including sulindac have shown potent chemopreventive and tumor regressive effects against colorectal cancer, the…”
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Sulfone metabolite of sulindac inhibits mammary carcinogenesis by THOMPSON, H. J, JIANG, C, LU, J, MEHTA, R. G, PIAZZA, G. A, PARANKA, N. S, PAMUKCU, R, AHNEN, D. J

“…Sulindac sulfoxide, a commonly prescribed anti-inflammatory drug, has cancer chemopreventive activity. During its metabolism, the inactive prodrug sulindac…”
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Sulindac independently modulates extracellular signal–regulated kinase 1/2 and cyclic GMP–dependent protein kinase signaling pathways by Rice, Pamela L, Peters, Stevany L, Beard, K Scott, Ahnen, Dennis J

“…Colorectal cancer is the second leading cause of cancer mortality in the United States. Substantial human and animal data support the ability of nonsteroidal…”
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Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells by RICE, Pamela L, WASHINGTON, Michele, SCHLEMAN, Shea, BEARD, K. Scott, DRIGGERS, Linda J, AHNEN, Dennis J

“…Colorectal cancer is the second leading cause of cancer death in the United States. Nonsteroidal anti-inflammatory drugs including sulindac are promising…”
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Variable phenotype of familial adenomatous polyposis in pedigrees with 3′ mutation in the APC gene by Brensinger, J D, Laken, S J, Luce, M C, Powell, S M, Vance, G H, Ahnen, D J, Petersen, G M, Hamilton, S R, Giardiello, F M

“…Background—Germline mutation in the adenomatous polyposis coli (APC) gene on chromosome 5 causes familial adenomatous polyposis. “Attenuated” phenotype has…”
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Risk factors for Ki-ras protooncogene mutation in sporadic colorectal adenomas by MARTINEZ, M. E, MALTZMAN, T, MARSHALL, J. R, EINSPAHR, J, REID, M. E, SAMPLINER, R, AHNEN, D. J, HAMILTON, S. R, ALBERTS, D. S

“…The Ki-ras protooncogene frequently is mutated in colorectal adenocarcinomas, but the etiology of this molecular event is uncertain. We investigated the…”
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