Search Results - "Ahn, Kwang Seok"

Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies by Mirzaei, Sepideh, Hushmandi, Kiavash, Zabolian, Amirhossein, Saleki, Hossein, Torabi, Seyed Mohammad Reza, Ranjbar, Adnan, SeyedSaleh, SeyedHesam, Sharifzadeh, Seyed Omid, Khan, Haroon, Ashrafizadeh, Milad, Zarrabi, Ali, Ahn, Kwang-Seok

“…The failure of chemotherapy is a major challenge nowadays, and in order to ensure effective treatment of cancer patients, it is of great importance to reveal…”
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Mechanisms of allergen-specific immunotherapy for allergic rhinitis and food allergies by Lam, Hiu Yan, Tergaonkar, Vinay, Ahn, Kwang Seok

“…Allergen-specific immunotherapy (AIT) is currently the only potential treatment for allergies including allergic rhinitis (AR) and food allergies (FA) that can…”
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Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB–regulated gene products and TAK1-mediated NF-κB activation by Sethi, Gautam, Ahn, Kwang Seok, Pandey, Manoj K., Aggarwal, Bharat B.

“…Celastrol, a quinone methide triterpene derived from the medicinal plant Tripterygium wilfordii, has been used to treat chronic inflammatory and autoimmune…”
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Targeting Nuclear Factor-κB Activation Pathway by Thymoquinone: Role in Suppression of Antiapoptotic Gene Products and Enhancement of Apoptosis by Sethi, Gautam, Ahn, Kwang Seok, Aggarwal, Bharat B

“…Thymoquinone (TQ), derived from the medicinal plant Nigella sativa , exhibits antiinflammatory and anticancer activities through mechanism(s) that is not fully…”
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Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-κB signaling pathway by Pandey, Manoj K., Sung, Bokyung, Ahn, Kwang Seok, Kunnumakkara, Ajaikumar B., Chaturvedi, Madan M., Aggarwal, Bharat B.

“…Gambogic acid (GA), a xanthone derived from the resin of the Garcinia hanburyi, has been recently demonstrated to bind transferrin receptor and exhibit…”
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Simvastatin, 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitor, suppresses osteoclastogenesis induced by receptor activator of nuclear factor‐κB ligand through modulation of NF‐κB pathway by Ahn, Kwang Seok, Sethi, Gautam, Chaturvedi, Madan M., Aggarwal, Bharat B.

“…Simvastatin, an inhibitor of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase, is a cholesterol‐lowering drug that may play a role in bone metabolism through a…”
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Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal by Kumar, Suneel, Mathew, Stephen O, Aharwal, Ravindra Prasad, Tulli, Hardeep Singh, Mohan, Chakrabhavi Dhananjaya, Sethi, Gautam, Ahn, Kwang-Seok, Webber, Kassidy, Sandhu, Sardul Singh, Bishayee, Anupam

“…Cancer represents the second most deadly disease and one of the most important public health concerns worldwide. Surgery, chemotherapy, radiation therapy, and…”
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Butein suppresses constitutive and inducible signal transducer and activator of transcription (STAT) 3 activation and STAT3-regulated gene products through the induction of a protein tyrosine phosphatase SHP-1 by Pandey, Manoj K, Sung, Bokyung, Ahn, Kwang Seok, Aggarwal, Bharat B

“…The aim of the current study is to determine whether butein (3,4,2',4'-tetrahydroxychalcone) exhibits antiproliferative effects against tumor cells through…”
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Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1 by Ahn, Kwang Seok, Sethi, Gautam, Sung, Bokyung, Goel, Ajay, Ralhan, Ranju, Aggarwal, Bharat B

“…Signal transducers and activator of transcription 3 (STAT3) is a transcription factor that has been associated with survival, proliferation, chemoresistance,…”
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Ursolic Acid Inhibits STAT3 Activation Pathway Leading to Suppression of Proliferation and Chemosensitization of Human Multiple Myeloma Cells by Pathak, Ashutosh K, Bhutani, Manisha, Nair, Asha S, Ahn, Kwang Seok, Chakraborty, Arup, Kadara, Humam, Guha, Sushovan, Sethi, Gautam, Aggarwal, Bharat B

“…The activation of signal transducers and activators of transcription 3 (STAT3) has been linked with the proliferation of a variety of human cancer cells,…”
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The aglycone of ginsenoside Rg3 enables glucagon-like peptide-1 secretion in enteroendocrine cells and alleviates hyperglycemia in type 2 diabetic mice by Kim, Ki-Suk, Jung Yang, Hea, Lee, In-Seung, Kim, Kang-Hoon, Park, Jiyoung, Jeong, Hyeon-Soo, Kim, Yoomi, Seok Ahn, Kwang, Na, Yun-Cheol, Jang, Hyeung-Jin

“…Ginsenosides can be classified on the basis of the skeleton of their aglycones. Here, we hypothesized that the sugar moieties attached to the dammarane…”
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Zerumbone down-regulates chemokine receptor CXCR4 expression leading to inhibition of CXCL12-induced invasion of breast and pancreatic tumor cells by Sung, Bokyung, Jhurani, Sonia, Ahn, Kwang Seok, Mastuo, Yoichi, Yi, Tingfang, Guha, Sushovan, Liu, Mingyao, Aggarwal, Bharat B

“…CXC chemokine receptor 4 (CXCR4), initially linked with leukocyte trafficking, is now known to be expressed in various tumors including breast, ovary,…”
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Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-κB–regulated gene products by Ahn, Kwang Seok, Sethi, Gautam, Chao, Ta-Hsiang, Neuteboom, Saskia T.C., Chaturvedi, Madan M., Palladino, Michael A., Younes, Anas, Aggarwal, Bharat B.

“…Salinosporamide A (also called NPI-0052), recently identified from the marine bacterium Salinispora tropica, is a potent inhibitor of 20S proteasome and…”
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Embelin Induces Apoptosis in Human Glioma Cells Through Inactivating NF-κB by Park, Sang-Yoon, Lim, Sung-Lyul, Jang, Hyeung-Jin, Lee, Jun-Hee, Um, Jae-Young, Kim, Sung-Hoon, Ahn, Kwang Seok, Lee, Seok-Geun

“…Aggressive tumor growth and diffuse tissue invasion are hallmarks of malignant glioma. Embelin is an active compound identified as a novel XIAP inhibitor from…”
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Paeonol Exerts Anti-angiogenic and Anti-metastatic Activities through Downmodulation of Akt Activation and Inactivation of Matrix Metalloproteinases by Kim, Seung-Ae, Lee, Hyo-Jeong, Ahn, Kwang Seok, Lee, Hyo-Jung, Lee, Eun-Ok, Ahn, Kyoo-Seok, Choi, Seung-Hoon, Jung, Soo-Jin, Kim, Ji Young, Baek, Namin, Kim, Sung-Hoon

“…Paeonol (2′-hydroxy-4′-methoxyacetophenone) is known to possess anti-inflammatory and anti-proliferative activities. Recently there is evidence that…”
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Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-κB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis by Kunnumakkara, Ajaikumar B., Nair, Asha S., Ahn, Kwang Seok, Pandey, Manoj K., Yi, Zhengfang, Liu, Mingyao, Aggarwal, Bharat B.

“…Gossypin, a flavone originally isolated from Hibiscus vitifolius, has been shown to suppress angiogenesis, inflammation, and carcinogenesis. The mechanisms of…”
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Ocimum sanctum induces apoptosis in A549 lung cancer cells and suppresses the in vivo growth of lewis lung carcinoma cells by Magesh, Venkataraman, Lee, Jang-Choon, Ahn, Kwang Seok, Lee, Hyo-Jung, Lee, Hyo-Jeong, Lee, Eun-Ok, Shim, Bum Sang, Jung, Hee Jae, Kim, Jin Sung, Kim, Dae Keun, Choi, Seung-Hoon, Ahn, Kyoo-Seok, Kim, Sung-Hoon

“…Although Ocimum sanctum has been used extensively for its medicinal values in India and China, its antitumor activity against human nonsmall cell lung…”
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The Role of Resveratrol in Cancer Therapy by Ko, Jeong-Hyeon, Sethi, Gautam, Um, Jae-Young, Shanmugam, Muthu K, Arfuso, Frank, Kumar, Alan Prem, Bishayee, Anupam, Ahn, Kwang Seok

“…Natural product compounds have recently attracted significant attention from the scientific community for their potent effects against inflammation-driven…”
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Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel by Lee, Jong Hyun, Kim, Chulwon, Sethi, Gautam, Ahn, Kwang Seok

“…Persistent phosphorylation of signal transducers and activators of transcription 3 (STAT3) is frequently observed in tumor cells. We found that brassinin (BSN)…”
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Therapeutic Emergence of Rhein as a Potential Anticancer Drug: A Review of Its Molecular Targets and Anticancer Properties by Henamayee, Sahu, Banik, Kishore, Sailo, Bethsebie Lalduhsaki, Shabnam, Bano, Harsha, Choudhary, Srilakshmi, Satti, Vgm, Naidu, Baek, Seung Ho, Ahn, Kwang Seok, Kunnumakkara, Ajaikumar B

“…According to the World Health Organization (WHO), cancer is the second-highest cause of mortality in the world, and it kills nearly 9.6 million people…”
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