Search Results - "Ahn, James H."

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models by Caldas-Lopes, Eloisi, Cerchietti, Leandro, Ahn, James H, Clement, Cristina C, Robles, Ana I, Rodina, Anna, Moulick, Kamalika, Taldone, Tony, Gozman, Alexander, Guo, Yunke, Wu, Nian, de Stanchina, Elisa, White, Julie, Gross, Steven S, Ma, Yuliang, Varticovski, Lyuba, Melnick, Ari, Chiosis, Gabriela

“…Triple-negative breast cancers (TNBCs) are defined by a lack of expression of estrogen, progesterone, and HER2 receptors. Because of the absence of identified…”
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HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans by Marubayashi, Sachie, Koppikar, Priya, Taldone, Tony, Abdel-Wahab, Omar, West, Nathan, Bhagwat, Neha, Caldas-Lopes, Eloisi, Ross, Kenneth N, Gönen, Mithat, Gozman, Alex, Ahn, James H, Rodina, Anna, Ouerfelli, Ouathek, Yang, Guangbin, Hedvat, Cyrus, Bradner, James E, Chiosis, Gabriela, Levine, Ross L

“…JAK2 kinase inhibitors were developed for the treatment of myeloproliferative neoplasms (MPNs), following the discovery of activating JAK2 mutations in the…”
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Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90 by Moulick, Kamalika, Ahn, James H, Zong, Hongliang, Rodina, Anna, Cerchietti, Leandro, Gomes DaGama, Erica M, Caldas-Lopes, Eloisi, Beebe, Kristin, Perna, Fabiana, Hatzi, Katerina, Vu, Ly P, Zhao, Xinyang, Zatorska, Danuta, Taldone, Tony, Smith-Jones, Peter, Alpaugh, Mary, Gross, Steven S, Pillarsetty, Nagavarakishore, Ku, Thomas, Lewis, Jason S, Larson, Steven M, Levine, Ross, Erdjument-Bromage, Hediye, Guzman, Monica L, Nimer, Stephen D, Melnick, Ari, Neckers, Len, Chiosis, Gabriela

“…The inhibitor PU-H71 preferentially targets tumor-enriched Hsp90 complexes. Affinity purification using PU-H71 reveals cancer-specific protein networks in…”
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Design, synthesis, and evaluation of small molecule Hsp90 probes by Taldone, Tony, Zatorska, Danuta, Patel, Pallav D., Zong, Hongliang, Rodina, Anna, Ahn, James H., Moulick, Kamalika, Guzman, Monica L., Chiosis, Gabriela

“…A number of compounds from different chemical classes are known to bind competitively to the ATP-pocket of Hsp90 and inhibit its chaperone function. The…”
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Design of a flexible cell-based assay for the evaluation of heat shock protein 70 expression modulators by Ahn, James H, Luo, Wenjie, Kim, Joungnam, Rodina, Anna, Clement, Cristina C, Aguirre, Julia, Sun, Weilin, Kang, Yanlong, Maharaj, Ronnie, Moulick, Kamalika, Zatorska, Danuta, Kokoszka, Malgorzata, Brodsky, Jeffrey L, Chiosis, Gabriela

“…Heat shock protein 70 (Hsp70) is a chaperone protein that helps protect against cellular stress, a function that may be co-opted to fight human diseases. In…”
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FLT3-ITD+ AML Blast, Progenitor and Stem Cell Populations Demonstrate Higher Sensitivity to the Hsp90 Inhibitor PU-H71 by Zong, Hongliang, Taldone, Tony, Ahn, James H., Brennan, Sarah, De Leon, Jeanne P., Becker, Michael W., Roboz, Gail J., Chiosis, Gabriela, Guzman, Monica L.

“…Abstract 3500 Hsp90, one of the best-characterized molecular chaperones, plays indispensable roles in folding and assembly, intracellular transport,…”
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Abstract 1263: Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90 by Gomes-DaGama, Erica M., Moulick, Kamalika, Ahn, James H., Zong, Hongliang, Rodina, Anna, Cerchietti, Leandro, Lopes-Vazquez, Maria E. Caldas, Beebe, Kristin, Perna, Fabiana, Katerina, Chatzi, Vu, Ly P., Zhao, Xinyang, Zatorska, Danuta, Taldone, Tony, Smith-Jones, Peter, Alpaugh, Mary, Gross, Steven S., Pillarsetty, Nagavarakishore, Ku, Thomas, Lewis, Jason S., Larson, Steven M., Ross, Levine, Erdjument-Bromage, Hediye, Guzman, Monica L., Nimer, Stephen D., Melnick, Ari M., Neckers, Len, Chiosis, Gabriela

“…Most cancers are characterized by multiple molecular alterations, but identification of the key proteins involved in these signaling pathways is currently…”
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Hsp9O Inhibitor PU-H71, a Multimodal Inhibitor of Malignancy, Induces Complete Responses in Triple-Negative Breast Cancer Models by Caldas-Lopes, Eloisi, Cerchietti, Leandro, Ahn, James H., Clement, Cristina C., Robles, Ana I., Rodina, Anna, Moulick, Kamalika, Taldone, Tony, Gozman, Alexander, Guo, Yunke, Wu, Nian, de Stanchina, Elisa, White, Julie, Gross, Steven S., Ma, Yuliang, Varticovski, Lyuba, Melnick, Ari, Chiosis, Gabriela, Danishefsky, Samuel J.

“…Triple-negative breast cancers (TNBCs) are defined by a lack of expression of estrogen, progesterone, and HER2 receptors. Because of the absence of identified…”
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Workup and management of traumatic hematuria by Ahn, J H, Morey, A F, McAninch, J W

“…Hematuria is an important indicator of genitourinary tract injury after trauma. Correct initial evaluation of hematuria will affect diagnosis, management, and…”
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