Effects of Plant Water-Soluble Polysaccharides on the Production of Immunoglobulins E and G1 by Lymphocytes of Mice Sensitized with Ovalbumin

Effects of Plant Water-Soluble Polysaccharides on the Production of Immunoglobulins E and G1 by Lymphocytes of Mice Sensitized with Ovalbumin

Were studied the effects of water-soluble plant polysaccharides isolated from pharmacopoeic raw material on anaphylactic shock and production of IgE and IgG1 by lymphocytes from mice immunized with ovalbumin. Course treatment with polysaccharides from coltsfoot, sweet flag, clover, Artemisia, marigo...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine Vol. 146; no. 5; pp. 585 - 587
Main Authors: Danilets, M. G, Belska, N. V, Bel'sky, Y. P, Uchasova, E. G, Trophimova, E. S, Ligatcheva, A. A, Guriev, A. M, Belousov, M. V, Ahmedganov, R. R, Usubov, M. S, Agaphonov, V. I
Format: Journal Article
Language:English
Published: Boston Boston : Springer US 01-11-2008
Springer US
Springer Nature B.V
Subjects:
anaphylaxis
Animals
Artemisia
atopy
Biomedical and Life Sciences
Biomedicine
Cell Biology
Enzyme-Linked Immunosorbent Assay
Female
Immunoglobulin E - metabolism
Immunoglobulin G - metabolism
immunoglobulins E and G1
Internal Medicine
Laboratory Medicine
Lymphocytes - drug effects
Lymphocytes - metabolism
Male
Mice
Mice, Inbred BALB C
Ovalbumin - pharmacology
Pathology
Pharmacology and Toxicology
Plants - chemistry
Polysaccharides - chemistry
Polysaccharides - pharmacology
Solubility
Water - chemistry
atopy
anaphylactic shock
immunoglobulins E and G1
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Summary:Were studied the effects of water-soluble plant polysaccharides isolated from pharmacopoeic raw material on anaphylactic shock and production of IgE and IgG1 by lymphocytes from mice immunized with ovalbumin. Course treatment with polysaccharides from coltsfoot, sweet flag, clover, Artemisia, marigold, and elecampane reduced animal mortality after induction of anaphylactic shock. In addition, injection of these substances reduced serum concentrations of IgE and IgG1. These substances can be regarded as promising agents for the treatment of IgE-dependent diseases (atopic dermatitis, asthma, atopic rhinitis, urticaria, food allergies, etc.).
Bibliography:http://dx.doi.org/10.1007/s10517-009-0351-3
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-009-0351-3