Search Results - "Ahmed Rasheed, B K"

Survival analysis of presumptive prognostic markers among oligodendrogliomas by McLendon, Roger E., Herndon, James E., West, Bryan, Reardon, David, Wiltshire, Rodney, Rasheed, B. K. Ahmed, Quinn, Jennifer, Friedman, Henry S., Friedman, Allan H., Bigner, Darell D.

“…BACKGROUND Allelic losses of 1p and 19q arms correlate with the oligodendroglial phenotype as well as with sensitivity to radiotherapy and chemotherapy…”
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AAL881, a novel small molecule inhibitor of RAF and vascular endothelial growth factor receptor activities, blocks the growth of malignant glioma by SATHORNSUMETEE, Sith, HJELMELAND, Anita B, BIGNER, Darell D, FRIEDMAN, Henry S, RICH, Jeremy N, KEIR, Stephen T, MCLENDON, Roger E, BATT, David, RAMSEY, Timothy, YUSUFF, Naeem, AHMED RASHEED, B. K, KIERAN, Mark W, LAFORME, Andrea

“…Malignant gliomas are highly proliferative and angiogenic cancers resistant to conventional therapies. Although RAS and RAF mutations are uncommon in gliomas,…”
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Central nervous system by Adamson, D Cory, Rasheed, B Ahmed K, McLendon, Roger E, Bigner, Darell D

“…Several different types of tumors, benign and malignant, have been identified in the central nervous system (CNS). The prognoses for these tumors are related…”
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ZD6474, a Novel Tyrosine Kinase Inhibitor of Vascular Endothelial Growth Factor Receptor and Epidermal Growth Factor Receptor, Inhibits Tumor Growth of Multiple Nervous System Tumors by RICH, Jeremy N, SATHORNSUMETEE, Sith, REARDON, David A, RYAN, Anderson J, WHEELER, Catherine, DIMERY, Isaiah, BIGNER, Darell D, FRIEDMAN, Henry S, KEIR, Stephen T, KIERAN, Mark W, LAFORME, Andrea, KAIPAINEN, Arja, MCLENDON, Roger E, GRANER, Michael W, AHMED RASHEED, B. K, LING WANG

“…Purpose: Primary central nervous system (CNS) tumors represent a diverse group of tumor types with heterogeneous molecular mechanisms that underlie their…”
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PTEN gene mutations are seen in high-grade but not in low-grade gliomas by AHMED RASHEED, B. K, STENZEL, T. T, MCLENDON, R. E, PARSONS, R, FRIEDMAN, A. H, FRIEDMAN, H. S, BIGNER, D. D, BIGNER, S. H

“…The PTEN gene, located on 10q23, has recently been implicated as a candidate tumor suppressor gene in brain, breast and prostate tumors. In the present study,…”
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Molecular pathogenesis of malignant gliomas by Ahmed Rasheed, B K, Wiltshire, Rodney N, Bigner, Sandra H, Bigner, Darell D

“…De novo glioblastomas develop in older patients without prior clinical history of less malignant tumors. Progressive glioblastomas are common among younger…”
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Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft by FRIEDMAN, H. S, JOHNSON, S. P, GERMAIN, G, DRUMMOND, J. T, KEIR, S, MARCELLI, S, BIGNER, D. D, MODRICH, P, DONG, Q, SCHOLD, S. C, AHMED RASHEED, B. K, BIGNER, S. H, ALI-OSMAN, F, DOLAN, E, COLVIN, O. M, HOUGHTON, P

“…A methylator-resistant human glioblastoma multiforme xenograft, D-245 MG (PR), in athymic nude mice was established by serially treating the parent xenograft…”
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Production and Characterization of Two Ependymoma Xenografts by McLendon, Roger E, Fung, Kar-Ming, Bentley, Rex C, Ahmed Rasheed, B K, Trojanowski, John Q, Bigner, Sandra H, Bigner, Darell D, Friedman, Henry S

“…Childhood ependymomas exhibit cpidemiologic, anatomic, histologic, and biologic features that distinguish them from other gliomas. Because of their propensity…”
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Phase II Trial of Gefitinib in Recurrent Glioblastoma by Rich, Jeremy N, Reardon, David A, Peery, Terry, Dowell, Jeannette M, Quinn, Jennifer A, Penne, Kara L, Wikstrand, Carol J, Van Duyn, Lauren B, Dancey, Janet E, McLendon, Roger E, Kao, James C, Stenzel, Timothy T, Ahmed Rasheed, B K, Tourt-Uhlig, Sandra E, Herndon, 2nd, James E, Vredenburgh, James J, Sampson, John H, Friedman, Allan H, Bigner, Darell D, Friedman, Henry S

“…To evaluate the efficacy and tolerability of gefitinib (ZD1839, Iressa; AstraZeneca, Wilmington, DE), a novel epidermal growth factor receptor tyrosine kinase…”
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Gene expression profiling and genetic markers in glioblastoma survival by RICH, Jeremy N, HANS, Christopher, WEST, Mike, JONES, Beatrix, IVERSEN, Edwin S, MCLENDON, Roger E, RASHEED, B. K, DOBRA, Adrian, DRESSMAN, Holly K, BIGNER, Darell D, NEVINS, Joseph R

“…Despite the strikingly grave prognosis for older patients with glioblastomas, significant variability in patient outcome is experienced. To explore the…”
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EGFR mutations and sensitivity to gefitinib by Rich, Jeremy N, Rasheed, B K Ahmed, Yan, Hai

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EGFR Mutations and Sensitivity to Gefitinib by Sorscher, Steven M

“…To the Editor: The important study by Dr. Lynch and colleagues (May 20 issue) 1 suggests that specific mutations in the epidermal growth factor receptor (EGFR)…”
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EGFR Mutations and Sensitivity to Gefitinib/THE AUTHORS REPLY by Sorscher, Steven M, Rich, Jeremy N, Ahmed Rasheed, B K, Yan, Hai

“…In response to Rich et al., the frequent amplification of EGFR in glioblastomas is well recognized, as is the presence of in-frame deletions within the…”
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Alterations of the TP53 gene in human gliomas by AHMED RESHEED, B. K, MCLENDON, R. E, HERNDON, J. E, FRIEDMAN, H. S, FRIEDMAN, A. H, BIGNER, D. D, BIGNER, S. H

“…Glial tumors of all grades and histological types from 72 adults and 48 children were analyzed for mutations of the TP53 gene, loss of heterozygosity (LOH) for…”
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Activation of potassium ion transport in mitochondria by cadmium ion by RASHEED, B. K. Ahmed, DIWAN, Joyce Johnson, SANADI, D. Rao

“…Low levels of Cd2+ (1–5 μM) produce rapid swelling of mitochondria, which is respiration‐dependent and uncoupler‐sensitive. No cation requirement is apparent,…”
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Loss of heterozygosity for 10q loci in human gliomas by Rasheed, B K, Fuller, G N, Friedman, A H, Bigner, D D, Bigner, S H

“…Cytogenetic and RFLP studies have shown that chromosome 10 is frequently lost in tumor cells from glioblastomas, suggesting that a suppressor gene important in…”
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Characterization of chromosome 17 abnormalities in medulloblastomas by ALDOSARI, N, AHMED RASHEED, B. K, MCLENDON, R. E, FRIEDMAN, H. S, BIGNER, D. D, BIGNER, S. H

“…Loss of portions of chromosome 17p, usually through the formation of i(17qp) is a well-known finding in medulloblastomas. Loss of heterozygosity (LOH) studies,…”
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Microsatellite analysis of childhood brain tumors by Blaeker, Hendrik, Ahmed Rasheed, B. K., McLendon, Roger E., Friedman, Henry S., Batra, Surinder K., Fuchs, Herbert E., Bigner, Sandra H.

“…Loss of heterozygosity at specific chromosomal locations has been taken as evidence of a tumor suppressor gene located in that area. We performed a genomic…”
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Oncogenes and anti-oncogenes in human central nervous system tumors by Batra, S K, Rasheed, B K, Bigner, S H, Bigner, D D

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Genetic alterations in glioma and medulloblastoma by RASHEED, B. K. A, BIGNER, S. H

“…Multiple genetic changes take place during tumor development and progression. These genetic changes result in inactivation of tumor suppressor genes and…”
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