Synthesis of 8-Aroyl-9-hydroxy-7,9,11-triaryl-3-oxo(or thioxo)-2,4-diazaspiro[5.5]undecane-1,5-diones

Synthesis of 8-Aroyl-9-hydroxy-7,9,11-triaryl-3-oxo(or thioxo)-2,4-diazaspiro[5.5]undecane-1,5-diones

A number of 8-aroyl-9-hydroxy-7,9,11-triaryl-3-oxo(or thioxo)-2,4-diazaspiro[5.5]undecane-1,5-diones 3a-g were synthesized from the reaction of 1,3-diaryl-2-propen-1-ones 2a-d with barbituric acid 1a and 2-thiobarbituric acid 1b in 50% aqueous ethanol under refluxing conditions without using any cat...

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Bibliographic Details
Published in:Synthetic communications Vol. 42; no. 8; pp. 1146 - 1153
Main Authors: Ahmed, S. Mosaddeq, Ahmed, M. Giasuddin, Ahmed, Syeda Asghari, Romman, U. K. R., Sultana, Tazin, Hossain, M. Mahmun, Hussam, Abul
Format: Journal Article
Language:English
Published: Philadelphia Taylor & Francis Group 15-04-2012
Taylor & Francis Ltd
Subjects:
2-thiobarbituric acid
Barbituric acid
chalcones
Michael addition
spiro compounds
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Summary:A number of 8-aroyl-9-hydroxy-7,9,11-triaryl-3-oxo(or thioxo)-2,4-diazaspiro[5.5]undecane-1,5-diones 3a-g were synthesized from the reaction of 1,3-diaryl-2-propen-1-ones 2a-d with barbituric acid 1a and 2-thiobarbituric acid 1b in 50% aqueous ethanol under refluxing conditions without using any catalyst. The structures of the compounds were confirmed by ultraviolet, infrared, 1 H and 13 C NMR, mass, and elemental analysis.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2010.536607