Search Results - "Ahmed, Mansoor M"

Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose? by Demaria, Sandra, Guha, Chandan, Schoenfeld, Jonathan, Morris, Zachary, Monjazeb, Arta, Sikora, Andrew, Crittenden, Marka, Shiao, Stephen, Khleif, Samir, Gupta, Seema, Formenti, Silvia Chiara, Vikram, Bhadrasain, Coleman, C Norman, Ahmed, Mansoor M

“…Recent evidence indicates that ionizing radiation can enhance immune responses to tumors. Advances in radiation delivery techniques allow hypofractionated…”
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Radiation and hypoxia-induced non-targeted effects in normoxic and hypoxic conditions in human lung cancer cells by Tubin, Slavisa, Ahmed, Mansoor M., Gupta, Seema

“…Purpose: Many cell lines with anaerobic metabolism do not show cytotoxic abscopal effect (AE) following irradiation. Further, there is no existing data on the…”
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Improving the Predictive Value of Preclinical Studies in Support of Radiotherapy Clinical Trials by Coleman, C Norman, Higgins, Geoff S, Brown, J Martin, Baumann, Michael, Kirsch, David G, Willers, Henning, Prasanna, Pataje G S, Dewhirst, Mark W, Bernhard, Eric J, Ahmed, Mansoor M

“…There is an urgent need to improve reproducibility and translatability of preclinical data to fully exploit opportunities for molecular therapeutics involving…”
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Targeting radiation‐induced upstream stimulatory factor‐1 by histone deacetylase inhibitors to reverse radioresistance in prostate cancer by Gupta, Seema, Ahmed, Mansoor M.

“…Background Ionizing radiation (IR) is a standard modality for the management of solid tumors. Apart from its killing effects, IR can induce pro‐survival…”
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Radiation-Induced Fibrosis: Mechanisms and Opportunities to Mitigate. Report of an NCI Workshop, September 19, 2016 by Citrin, Deborah E., Prasanna, Pataje G. S., Walker, Amanda J., Freeman, Michael L., Eke, Iris, Barcellos-Hoff, Mary Helen, Arankalayil, Molykutty J., Cohen, Eric P., Wilkins, Ruth C., Ahmed, Mansoor M., Anscher, Mitchell S., Movsas, Benjamin, Buchsbaum, Jeffrey C., Mendonca, Marc S., Wynn, Thomas A., Coleman, C. Norman

“…A workshop entitled “Radiation-Induced Fibrosis: Mechanisms and Opportunities to Mitigate” (held in Rockville, MD, September 19, 2016) was organized by the…”
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TLR4 activates the β-catenin pathway to cause intestinal neoplasia by Santaolalla, Rebeca, Sussman, Daniel A, Ruiz, Jose R, Davies, Julie M, Pastorini, Cristhine, España, Cecilia L, Sotolongo, John, Burlingame, Oname, Bejarano, Pablo A, Philip, Sakhi, Ahmed, Mansoor M, Ko, Jeffrey, Dirisina, Ramanarao, Barrett, Terrence A, Shang, Limin, Lira, Sergio A, Fukata, Masayuki, Abreu, Maria T

“…Colonic bacteria have been implicated in the development of colon cancer. We have previously demonstrated that toll-like receptor 4 (TLR4), the receptor for…”
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Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3 by CHENDIL, Damodaran, RANGA, Rama S, MEIGOONI, David, SATHISHKUMAR, Sabapathi, AHMED, Mansoor M

“…Curcumin (Diferuloylmethane) is a major chemical component of turmeric (curcuma longa) and is used as a spice to give a specific flavor and yellow color in…”
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Defining Molecular Signature of Pro-Immunogenic Radiotherapy Targets in Human Prostate Cancer Cells by Aryankalayil, Molykutty J., Makinde, Adeola Y., Gameiro, Sofia R., Hodge, James W., Rivera-Solis, Patricia P., Palayoor, Sanjeewani T., Ahmed, Mansoor M., Coleman, C. Norman

“…To understand the impact of clinically relevant radiation therapy (RT) on tumor immune gene expression and to utilize the changes that occur during treatment…”
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Low-dose fractionated radiation potentiates the effects of cisplatin independent of the hyper-radiation sensitivity in human lung cancer cells by Gupta, Seema, Koru-Sengul, Tulay, Arnold, Susanne M, Devi, Gayathri R, Mohiuddin, Mohammed, Ahmed, Mansoor M

“…In this study, the role of hyper-radiation sensitivity (HRS) in potentiating the effects of cisplatin by low-dose fractionated radiation (LDFRT) was evaluated…”
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Nose-Cone Conformal Substrate-Integrated Waveguide Slot Array Antenna for X-Band Radar Applications by Khalil, Hisham, Rafique, Umair, Ahmed, M. Mansoor

“…This paper presents the design of nose-cone conformal substrate-integrated waveguide (SIW) slot array antenna for modern radar applications. Firstly, the wave…”
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Na,K-ATPase subunits as markers for epithelial-mesenchymal transition in cancer and fibrosis by Rajasekaran, Sigrid A, Huynh, Thu P, Wolle, Daniel G, Espineda, Cromwell E, Inge, Landon J, Skay, Anna, Lassman, Charles, Nicholas, Susanne B, Harper, Jeffrey F, Reeves, Anna E, Ahmed, Mansoor M, Leatherman, James M, Mullin, James M, Rajasekaran, Ayyappan K

“…Epithelial-to-mesenchymal transition (EMT) is an important developmental process, participates in tissue repair, and occurs during pathologic processes of…”
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The E2F1/Rb and p53/MDM2 Pathways in DNA Repair and Apoptosis: Understanding the Crosstalk to Develop Novel Strategies for Prostate Cancer Radiotherapy by Udayakumar, Thirupandiyur, PhD, Shareef, Mohammed M., PhD, Diaz, Dayssy A., MD, Ahmed, Mansoor M., PhD, Pollack, Alan, MD, PhD

“…Both the p53- and E2F1-signaling pathways are defective in almost all types of tumors, suggesting very important roles for their signaling networks in…”
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Incorporating Radiation Oncology into Immunotherapy: proceedings from the ASTRO-SITC-NCI immunotherapy workshop by Marciscano, Ariel E, Walker, Joshua M, McGee, Heather M, Kim, Michelle M, Kunos, Charles A, Monjazeb, Arta M, Shiao, Stephen L, Tran, Phuoc T, Ahmed, Mansoor M

“…Radiotherapy (RT) has been a fundamental component of the anti-cancer armamentarium for over a century. Approximately half of all cancer patients are treated…”
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Adenovirus E2F1 Overexpression Sensitizes LNCaP and PC3 Prostate Tumor Cells to Radiation In Vivo by Udayakumar, Thirupandiyur S., Ph.D, Stoyanova, Radka, Ph.D, Hachem, Paul, B.S, Ahmed, Mansoor M., Ph.D, Pollack, Alan, M.D., Ph.D

“…Purpose We previously showed that E2F1 overexpression radiosensitizes prostate cancer cells in vitro . Here, we demonstrate the radiosensitization efficacy of…”
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Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy by Prasanna, Pataje G, Citrin, Deborah E, Hildesheim, Jeffrey, Ahmed, Mansoor M, Venkatachalam, Sundar, Riscuta, Gabriela, Xi, Dan, Zheng, Guangrong, Deursen, Jan van, Goronzy, Jorg, Kron, Stephen J, Anscher, Mitchell S, Sharpless, Norman E, Campisi, Judith, Brown, Stephen L, Niedernhofer, Laura J, O’Loghlen, Ana, Georgakilas, Alexandros G, Paris, Francois, Gius, David, Gewirtz, David A, Schmitt, Clemens A, Abazeed, Mohamed E, Kirkland, James L, Richmond, Ann, Romesser, Paul B, Lowe, Scott W, Gil, Jesus, Mendonca, Marc S, Burma, Sandeep, Zhou, Daohong, Coleman, C Norman

“…Abstract Cellular senescence is an essential tumor suppressive mechanism that prevents the propagation of oncogenically activated, genetically unstable, and/or…”
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Implementation of New Biology-Based Radiation Therapy Technology: When Is It Ready So “Perfect Makes Practice?” by Coleman, C. Norman, Ahmed, Mansoor M.

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Durvalumab plus tremelimumab alone or in combination with low-dose or hypofractionated radiotherapy in metastatic non-small-cell lung cancer refractory to previous PD(L)-1 therapy: an open-label, multicentre, randomised, phase 2 trial by Schoenfeld, Jonathan D, Giobbie-Hurder, Anita, Ranasinghe, Srinika, Kao, Katrina Z, Lako, Ana, Tsuji, Junko, Liu, Yang, Brennick, Ryan C, Gentzler, Ryan D, Lee, Carrie, Hubbard, Joleen, Arnold, Susanne M, Abbruzzese, James L, Jabbour, Salma K, Uboha, Nataliya V, Stephans, Kevin L, Johnson, Jennifer M, Park, Haeseong, Villaruz, Liza C, Sharon, Elad, Streicher, Howard, Ahmed, Mansoor M, Lyon, Hayley, Cibuskis, Carrie, Lennon, Niall, Jhaveri, Aashna, Yang, Lin, Altreuter, Jennifer, Gunasti, Lauren, Weirather, Jason L, Mak, Raymond H, Awad, Mark M, Rodig, Scott J, Chen, Helen X, Wu, Catherine J, Monjazeb, Arta M, Hodi, F Stephen

“…Patients with non-small-cell lung cancer (NSCLC) that is resistant to PD-1 and PD-L1 (PD[L]-1)-targeted therapy have poor outcomes. Studies suggest that…”
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Best practices and novel approaches for the preclinical development of drug–radiotherapy combinations for cancer treatment by Prasanna, Pataje G S, Ahmed, Mansoor M, Hong, Julie A, Coleman, C Norman

“…Drug–radiation combination therapy is a practical approach to improving clinical outcomes for many tumours. Unfortunately, most clinical combination studies…”
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Elevated sphingomyelinase activity and ceramide concentration in serum of patients undergoing high dose spatially fractionated radiation treatment: Implications for endothelial apoptosis by Sathishkumar, Sabapathi, Boyanovski, Boris, Karakashian, Alexander, Rozenova, Krassimira A., Giltiay, Natalia V., Kudrimoti, Mahesh, Mohiuddin, Mohammed, Ahmed, Mansoor M., Nikolova-Karakashian, Mariana

“…Spatially Fractionated high dose (Grid) Radiation Treatment (SFGRT) involves irradiation of bulky tumors with one high, grid-delivered, dose of 15 Gy followed…”
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Low-Dose Fractionated Radiation Potentiates the Effects of Paclitaxel in Wild-type and Mutant p53 Head and Neck Tumor Cell Lines by DEY, Swatee, SPRING, Paul M, ARNOLD, Suzanne, VALENTINO, Joseph, CHENDIL, Damodaran, REGINE, William F, MOHIUDDIN, Mohammed, AHMED, Mansoor M

“…This study was designed to: ( a ) evaluate the induction of hyper-radiation sensitivity (HRS), a phenomenon observed at low doses of radiation (<1 Gy); ( b )…”
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