Search Results - "Ahmed, Kawkab"

Neuroprotective Potential of Berberine Against Doxorubicin-Induced Toxicity in Rat’s Brain by Ibrahim Fouad, Ghadha, Ahmed, Kawkab A.

“…Chemotherapy-associated neurotoxicity is one of the principal side-effects for doxorubicin (DOX)-treated cancer patients. Despite its poor-penetration across…”
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Irinotecan-gut microbiota interactions and the capability of probiotics to mitigate Irinotecan-associated toxicity by Mahdy, Marwa S, Azmy, Ahmed F, Dishisha, Tarek, Mohamed, Wafaa R, Ahmed, Kawkab A, Hassan, Ahmed, Aidy, Sahar El, El-Gendy, Ahmed O

“…Irinotecan is a chemotherapeutic agent used to treat a variety of tumors, including colorectal cancer (CRC). In the intestine, it is transformed into SN-38 by…”
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Curcumin Ameliorates Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity Via Suppressing Oxidative Stress and Modulating iNOS, NF-κB, and TNF-α in Rats by Ibrahim Fouad, Ghadha, Ahmed, Kawkab A.

“…Doxorubicin (DOX) is one of the widely used anti-tumor drugs. However, DOX-induced cardiotoxicity (DIC) and hepatotoxicity (DIH) are among the side effects…”
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The protective impact of berberine against doxorubicin-induced nephrotoxicity in rats by Ibrahim Fouad, Ghadha, Ahmed, Kawkab A.

“…•Doxorubicin (DOX) administration induced nephrotoxicity and renal fibrosis in rats.•Berberine (BEB) demonstrated a nephroprotective potential against…”
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Remyelinating activities of Carvedilol or alpha lipoic acid in the Cuprizone-Induced rat model of demyelination by Ibrahim Fouad, Ghadha, Ahmed, Kawkab A.

“…•Cuprizone feeding induced neurotoxicity, neuroinflammation, and demyelination.•Both Carvedilol and ALA exerted pro-remyelinating, anti-oxidative, and…”
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Safety of inhaled ivermectin as a repurposed direct drug for treatment of COVID-19: A preclinical tolerance study by M. Mansour, Suzan, N. Shamma, Rehab, A. Ahmed, Kawkab, A. Sabry, Nirmeen, Esmat, Gamal, A. Mahmoud, Azza, Maged, Amr

“…[Display omitted] •Fast dissolved lyophilized ivermectin-cyclodextrin formulation was developed.•Ivermectin aqueous solubility increased 127-fold in…”
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The neuroprotective effect of pterostilbene on oxaliplatin-induced peripheral neuropathy via its anti-inflammatory, anti-oxidative and anti-apoptotic effects: Comparative study with celecoxib by Abd-Elmawla, Mai A., Abdelalim, Eman, Ahmed, Kawkab A., Rizk, Sherine M.

“…Oxaliplatin is one of the first-line drugs in solid tumors treatment. However, neuropathy is a devastating side effect leading to poor compliance and treatment…”
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Assessment of the hepatoprotective effect of developed lipid-polymer hybrid nanoparticles (LPHNPs) encapsulating naturally extracted β-Sitosterol against CCl4 induced hepatotoxicity in rats by Abdou, Ebtsam M., Fayed, Marwa A. A., Helal, Doaa, Ahmed, Kawkab A.

“…The hepatoprotective effect of β -Sitosterol (BSS), a natural phytosterol, after being formulated into a suitable pharmaceutical drug delivery system has not…”
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Resveratrol mitigates diclofenac‐induced hepatorenal toxicity in rats via modulation of miR‐144/Nrf2/GSH axis by Elbaz, Eman M., Ahmed, Kawkab A., Abdelmonem, Maha

“…Despite the extensive therapeutic uses of diclofenac, it may cause several adverse effects, including hepatorenal injury. The antioxidant and anti‐inflammatory…”
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Protective role of functional food in cognitive deficit in young and senile rats by Attia, Hanan Naeim, Ahmed, Kawkab A.

“…Cognitive decline and neurodegenerative diseases pose a significant burden on healthcare resources both in developed and developing countries which is a major…”
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Hibiscus sabdariffa L.: A potent natural neuroprotective agent for the prevention of streptozotocin-induced Alzheimer’s disease in mice by El-Shiekh, Riham A., Ashour, Rehab M., Abd El-Haleim, Enas A., Ahmed, Kawkab A., Abdel-Sattar, Essam

“…[Display omitted] •Hibiscus was able to reverse the STZ-induced upregulation in the amyloidogenic pathway.•As well as targeting COX-2/mPGES-1 in PGE2…”
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Assessment of the Biological Activities of Egyptian Purslane (Portulaca oleracea) Extract after Incorporating Metal Nanoparticles, in Vitro and in Vivo Study by Aboulthana, Wael Mahmoud, Omar, Nagwa Ibrahim, Hasan, Enas Ahmed, Ahmed, Kawkab A, Youssef, Ahmed Mahmoud

“…Egyptian Purslane (Portulaca oleracea) is rich in omega-3 fatty acids and a wide range of vitamins and phyto-constituents that were absorbed slowly due to…”
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Evaluation of the skin protective effects of niosomal-entrapped annona squamosa against UVA irradiation by Mohamad, Ebtesam A, Ahmed, Kawkab A, Mohammed, Haitham S

“…Annona squamosa is a medicinal plant that has been used in folk medicine since antiquity. The goal of this study is to see how effective Annona squamosa leaf…”
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Crosstalk Among NLRP3 Inflammasome, ETBR Signaling, and miRNAs in Stress-Induced Depression-Like Behavior: a Modulatory Role for SGLT2 Inhibitors by Muhammad, Radwa N., Ahmed, Lamiaa A., Abdul Salam, Rania M., Ahmed, Kawkab A., Attia, Amina S.

“…Depression is an overwhelming health concern, and many patients fail to optimally respond to available standard therapies. Neuroplasticity and blood–brain…”
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Donepezil halts acetic acid-induced experimental colitis in rats and its associated cognitive impairment through regulating inflammatory/oxidative/apoptotic cascades: An add-on to its anti-dementia activity by Elbaz, Eman M., Essam, Reham M., Ahmed, Kawkab A., Safwat, Maheera H.

“…[Display omitted] •The study reported the protective effect of DON against acetic acid-induced colitis in rats.•Our work also demonstrated that DON guards…”
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Vitamin D and rosuvastatin obliterate peripheral neuropathy in a type-2 diabetes model through modulating Notch1, Wnt-10α, TGF-β and NRF-1 crosstalk by El-Sawaf, Engie S, Saleh, Samira, Abdallah, Dalaal M, Ahmed, Kawkab A, El-Abhar, Hanan S

“…Aims Vitamin D and rosuvastatin are well-known drugs that mediate beneficial effects in treating type-2 diabetes (T2D) complications; however, their…”
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Repositioning of Ticagrelor: Renoprotection mediated by modulating renin-angiotensin system, inflammation, autophagy and galectin-3 by Mansour, Suzan M., Abd El-Aal, Sarah A., El-Abhar, Hanan S., Ahmed, Kawkab A., Awny, Magdy M.

“…Aside from being an antiplatelet, ample studies revealed the anti-ischemic cardioprotective effect of Ticagrelor (Tica) mediated via different mechanisms;…”
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Repurposing of nifedipine loaded in situ ophthalmic gel as a novel approach for glaucoma treatment by El-Feky, Yasmin A., Fares, Ahmed Roshdy, Zayed, Gamal, El-Telbany, Rania Farag A., Ahmed, Kawkab A., El-Telbany, Dalia Farag A.

“…Glaucoma is a chronic eye disease characterized by elevated intraocular pressure (IOP) which causes severe complications to the eyes and may lead to vision…”
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Demotion of canonical/non-canonical inflammasome and pyroptosis alleviates ischemia/reperfusion-induced acute kidney injury: Novel role of the D2/D3 receptor agonist ropinirole by Henedak, Nada T., El-Abhar, Hanan S., Abdallah, Dalaal M., Ahmed, Kawkab A., Soubh, Ayman A.

“…Ropinirole used to treat Parkinson's disease highly targets the dopaminergic receptor D3 over the D2 receptor but although both are expressed in the kidneys…”
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Genistein and/or sulfasalazine ameliorate acetic acid-induced ulcerative colitis in rats via modulating INF-γ/JAK1/STAT1/IRF-1, TLR-4/NF-κB/IL-6, and JAK2/STAT3/COX-2 crosstalk by Elhefnawy, Esraa A., Zaki, Hala F., El Maraghy, Nabila N., Ahmed, Kawkab A., Abd El-Haleim, Enas A.

“…[Display omitted] Ulcerative Colitis (UC) is a chronic idiopathic inflammatory bowel disease in which the colon’s lining becomes inflamed. Exploring herbal…”
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