Search Results - "Ahmed, Esam R"

Synthesis, antitumour and antioxidant activities of novel α,β-unsaturated ketones and related heterocyclic analogues: EGFR inhibition and molecular modelling study by El-Husseiny, Walaa M., El-Sayed, Magda A.-A., Abdel-Aziz, Naglaa I., El-Azab, Adel S., Ahmed, Esam R., Abdel-Aziz, Alaa A.-M.

“…New α,β-unsaturated ketones 4a,b; 5a-c; and 6a,b; as well as 4-H pyran 7; pyrazoline 8a,b; isoxazoline 9; pyridine 10-11; and quinoline-4-carboxylic acid 12a,b…”
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Synthesis and biological evaluation of novel 5-chloro-N-(4-sulfamoylbenzyl) salicylamide derivatives as tubulin polymerization inhibitors by Galal, Alaaeldin M. F, Soltan, Maha M, Ahmed, Esam R, Hanna, Atef G

“…A novel series of sulfonamide derivatives, coupled with a salicylamide scaffold, was designed and synthesized. The structures of the synthesized compounds were…”
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Potent combretastatin A-4 analogs containing 1,2,4-triazole: Synthesis, antiproliferative, anti-tubulin activity, and docking study by Mustafa, Muhamad, Anwar, Sirajudheen, Elgamal, Firgani, Ahmed, Esam R., Aly, Omar M.

“…A series of cis restricted 1,2,4-triazole analogs of combretastatin A-4 (CA-4) were designed and synthesized. The antiproliferative activity of these compounds…”
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Azole-hydrazone derivatives: Design, synthesis, in vitro biological evaluation, dual EGFR/HER2 inhibitory activity, cell cycle analysis and molecular docking study as anticancer agents by Labib, Madlen B., Philoppes, John N., Lamie, Phoebe F., Ahmed, Esam R.

“…[Display omitted] •Novel azole-hydrazone hybrids were synthesized.•They screened in vitro against MCF-7 and HepG2 cell lines.•EGFR, HER2 and VEGFR inhibition…”
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Discovery of antiproliferative and anti-FAK inhibitory activity of 1,2,4-triazole derivatives containing acetamido carboxylic acid skeleton by Mustafa, Muhamad, Abuo-Rahma, Gamal El-Din A., Abd El-Hafeez, Amer Ali, Ahmed, Esam R., Abdelhamid, Dalia, Ghosh, Pradipta, Hayallah, Alaa M.

“…[Display omitted] •A series of 1,2,4-triazoles were designed and synthesized as potent FAK kinase inhibitors.•The In vitro antiproliferative activity was…”
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Targeted anticancer potential against glioma cells of thymoquinone delivered by mesoporous silica core-shell nanoformulations with pH-dependent release by Shahein, Samar A, Aboul-Enein, Ahmed M, Higazy, Iman M, Abou-Elella, Faten, Lojkowski, Witold, Ahmed, Esam R, Mousa, Shaker A, AbouAitah, Khaled

“…Glioma is one of the most aggressive primary brain tumors and is incurable. Surgical resection, radiation, and chemotherapies have been the standard treatments…”
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Aryl azide-sulfonamide hybrids induce cellular apoptosis: synthesis and preliminary screening of their cytotoxicity in human HCT116 and A549 cancer cell lines by El-Kardocy, Ahmed, Mustafa, Muhamad, Ahmed, Esam R., Mohamady, Samy, Mostafa, Yaser A.

“…Simple, small, drug-like molecules bearing aryl azide and aryl sulfonamide moieties were designed and synthesized. The cytotoxic activity of these compounds…”
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One-pot synthesis of spiro(indoline-3,4′-pyrazolo[3,4-b]pyridine)-5′-carbonitriles as p53-MDM2 interaction inhibitors by Ibrahim, Hany S, Eldehna, Wagdy M, Fallacara, Anna Lucia, Ahmed, Esam R, Ghabbour, Hazem A, Elaasser, Mahmoud M, Botta, Maurizio, Abou-seri, Sahar M, Abdel-Aziz, Hatem A

“…Inhibition of P53-mdm2 interaction will lead to cancer cell apoptosis. This strategy was achieved by reported spiro-oxindole derivatives…”
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Cytotoxicity of multicellular cancer spheroids, antibacterial, and antifungal of selected sulfonamide derivatives coupled with a salicylamide and/or anisamide scaffold by Galal, Alaaeldin M. F., Fayad, Walid, Mettwally, Walaa S. A., Gomaa, Sanaa K., Ahmed, Esam R., El-Refai, Heba A., Hanna, Atef G.

“…In an attempt to overcome the drawbacks of the cancer monolayers model (2D), the 3-dimensional (3D) multicellular cancer spheroids (MCS) have been developed…”
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