Search Results - "Ahmed, Ambar"

Generation of stable PDX derived cell lines using conditional reprogramming by Borodovsky, Alexandra, McQuiston, Travis J, Stetson, Daniel, Ahmed, Ambar, Whitston, David, Zhang, Jingwen, Grondine, Michael, Lawson, Deborah, Challberg, Sharon S, Zinda, Michael, Pollok, Brian A, Dougherty, Brian A, D'Cruz, Celina M

“…Efforts to develop effective cancer therapeutics have been hindered by a lack of clinically predictive preclinical models which recapitulate this complex…”
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Interneuronal transfer of human tau between Lamprey central neurons in situ by Kim, Wonhee, Lee, Sangmook, Jung, Cheolwha, Ahmed, Ambar, Lee, Gloria, Hall, Garth F

“…The mechanisms by which tau-containing lesions are propagated between adjacent and synaptically interconnected parts of the brain are a potentially important…”
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Comparative analysis of primary versus relapse/refractory DLBCL identifies shifts in mutation spectrum by Greenawalt, Danielle M, Liang, Winnie S, Saif, Sakina, Johnson, Justin, Todorov, Petar, Dulak, Austin, Enriquez, Daniel, Halperin, Rebecca, Ahmed, Ambar, Saveliev, Vladislav, Carpten, John, Craig, David, Barrett, J Carl, Dougherty, Brian, Zinda, Michael, Fawell, Stephen, Dry, Jonathan R, Byth, Kate

“…Current understanding of the mutation spectrum of relapsed/refractory (RR) tumors is limited. We performed whole exome sequencing (WES) on 47 diffuse large B…”
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The Nature of Extracellular Iron Influences Iron Acquisition by Mycobacterium tuberculosis Residing within Human Macrophages by OLAKANMI, Oyebode, SCHLESINGER, Larry S, AHMED, Ambar, BRITIGAN, Bradley E

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Intraphagosomal Mycobacterium tuberculosis Acquires Iron from Both Extracellular Transferrin and Intracellular Iron Pools by Olakanmi, Oyebode, Schlesinger, Larry S., Ahmed, Ambar, Britigan, Bradley E.

“…Mycobacterium tuberculosis multiplies within the macrophage phagosome and requires iron for growth. We examined the route(s) by which intracellular M…”
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Acquired Resistance to the Mutant-Selective EGFR Inhibitor AZD9291 Is Associated with Increased Dependence on RAS Signaling in Preclinical Models by Eberlein, Catherine A, Stetson, Daniel, Markovets, Aleksandra A, Al-Kadhimi, Katherine J, Lai, Zhongwu, Fisher, Paul R, Meador, Catherine B, Spitzler, Paula, Ichihara, Eiki, Ross, Sarah J, Ahdesmaki, Miika J, Ahmed, Ambar, Ratcliffe, Laura E, O'Brien, Elizabeth L Christey, Barnes, Claire H, Brown, Henry, Smith, Paul D, Dry, Jonathan R, Beran, Garry, Thress, Kenneth S, Dougherty, Brian, Pao, William, Cross, Darren A E

“…Resistance to targeted EGFR inhibitors is likely to develop in EGFR-mutant lung cancers. Early identification of innate or acquired resistance mechanisms to…”
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Abstract A63: Examination of ctDNA false positive variants reported from commercial vendors by ultrasensitive orthogonal testing by Stetson, Daniel, Ahmed, Ambar, Nuttall, Barrett, Lubinski, Tristan, Barrett, J. Carl, Dougherty, Brian

“…Noninvasive circulating tumor DNA (ctDNA) assays have the potential to revolutionize clinical trial design; however, challenges still remain in using ctDNA for…”
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Identification of a Molecularly-Defined Subset of Breast and Ovarian Cancer Models that Respond to WEE1 or ATR Inhibition, Overcoming PARP Inhibitor Resistance by Serra, Violeta, Wang, Anderson T, Castroviejo-Bermejo, Marta, Polanska, Urszula M, Palafox, Marta, Herencia-Ropero, Andrea, Jones, Gemma N, Lai, Zhongwu, Armenia, Joshua, Michopoulos, Filippos, Llop-Guevara, Alba, Brough, Rachel, Gulati, Aditi, Pettitt, Stephen J, Bulusu, Krishna C, Nikkilä, Jenni, Wilson, Zena, Hughes, Adina, Wijnhoven, Paul W G, Ahmed, Ambar, Bruna, Alejandra, Gris-Oliver, Albert, Guzman, Marta, Rodríguez, Olga, Grueso, Judit, Arribas, Joaquin, Cortés, Javier, Saura, Cristina, Lau, Alan, Critchlow, Susan, Dougherty, Brian, Caldas, Carlos, Mills, Gordon B, Barrett, J Carl, Forment, Josep V, Cadogan, Elaine, Lord, Christopher J, Cruz, Cristina, Balmaña, Judith, O'Connor, Mark J

“…PARP inhibitors (PARPi) induce synthetic lethality in homologous recombination repair (HRR)-deficient tumors and are used to treat breast, ovarian, pancreatic,…”
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Abstract LB-223: Examination of intra-assay variability in a commercial ctDNA NGS assay with triplicate clinical plasma and pooled normal samples by Stetson, Daniel, Dougherty, Brian, Ahmed, Ambar, Nuttall, Barrett, Lubinski, Tristan J., Afshar, Fakhera, Raymond, Amelia, Barrett, Carl

“…The increased reliance on liquid biopsy next generation sequencing assays for oncology clinical decisions has highlighted the importance of understanding the…”
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Abstract 240: Functional significance of co-occurring mutations in PIK3CA and MAP3K1 in breast cancer by Avivar-Valderas, Alvaro, McEwen, Robert, Taheri-Ghahfarokhi, Amir, Ahmed, Ambar, Stetson, Daniel, Dougherty, Brian, Maresca, Marcello, Hudson, Kevin, Cruzalegui, Francisco

“…PI3Kα signalling pathway is frequently hyper-activated in breast cancer (BrCa) with mutations of PIK3CA (∼45%) frequently found in luminal A BrCa samples…”
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Abstract LB-249: Examination of analytical factors impacting concordance of plasma-tumor testing by next-generation sequencing (NGS) by Stetson, Daniel, Dougherty, Brian, Ahmed, Ambar, Lubinski, Tristan, Markovets, Aleksandra, Thress, Kenneth, McEwen, Robert, Schiavon, Gaia, Whitston, David, Nuttall, Barrett, Barrett, J. Carl

“…The increased usage of circulating tumor DNA (ctDNA) sequencing for oncology clinical research demonstrates a critical need for sensitive and specific testing…”
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Abstract 1706: Whole exome sequencing of pre and post treatment diffuse large B cell lymphoma reveals the mutation spectrum of the relapse/refractory patient population by Greenawalt, Danielle, Byth, Kate, Lai, Zhongwu, Johnson, Justin, Ahmed, Ambar, Dougherty, Brian, Thress, Kenneth, Zinda, Michael, Liang, Winnie S., Carpten, John, Fawell, Stephen, Barrett, J. Carl

“…Our current understanding of the mutation spectrum of relapse/refractory patients is limited. Several published studies describing the mutational landscape of…”
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Abstract 641: Use of conditional reprogramming to develop and characterize cell cultures from patient-derived xenograft (PDX) models of human lung and ovarian cancer by Borodovsky, Alexandra, McQuiston, Travis J., Dougherty, Brian, Ahmed, Ambar, Whitston, David, Stetson, Daniel, Hubbard, Gretchen K., Challberg, Sharon S., Pollok, Brian A., D’Cruz, Celina M.

“…Patient-derived xenografts (PDX) are widely recognized as a more physiologically relevant preclinical model to standard cell line xenografts. PDX models…”
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Candidate predictive biomarkers for response to olaparib in advanced gastric cancer (AGC) by Hodgson, Darren R, Lai, Zhongwu, Dougherty, Brian Andrew, Ahmed, Ambar, Locker, Gershon Y., Sharpe, Alan, Ho, Tony Weishiu, Im, Seock-Ah, Kim, Woo Ho, Barrett, J Carl, Bang, Yung-Jue

“…Abstract only…”
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Intraphagosomal Mycobacterium tuberculosis acquires iron from both extracellular transferrin and intracellular iron pools. Impact of interferon-gamma and hemochromatosis by Olakanmi, Oyebode, Schlesinger, Larry S, Ahmed, Ambar, Britigan, Bradley E

“…Mycobacterium tuberculosis multiplies within the macrophage phagosome and requires iron for growth. We examined the route(s) by which intracellular M…”
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Dietary Supplementation with S-Adenosyl Methionine Delays the Onset of Motor Neuron Pathology in a Murine Model of Amyotrophic Lateral Sclerosis by Suchy, James, Lee, Sangmook, Ahmed, Ambar, Shea, Thomas B.

“…The full range of causative factors in Amyotrophic lateral sclerosis (ALS) remains elusive, but oxidative stress is recognized as a contributing factor…”
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