Search Results - "Ahmann, G"

Tumor-associated macrophages and extracellular matrix metalloproteinase inducer in prognosis of multiple myeloma by Panchabhai, S, Kelemen, K, Ahmann, G, Sebastian, S, Mantei, J, Fonseca, R

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BCL-2 family proteins as 5-Azacytidine-sensitizing targets and determinants of response in myeloid malignancies by Bogenberger, J M, Kornblau, S M, Pierceall, W E, Lena, R, Chow, D, Shi, C-X, Mantei, J, Ahmann, G, Gonzales, I M, Choudhary, A, Valdez, R, Camoriano, J, Fauble, V, Tiedemann, R E, Qiu, Y H, Coombes, K R, Cardone, M, Braggio, E, Yin, H, Azorsa, D O, Mesa, R A, Stewart, A K, Tibes, R

“…Synergistic molecular vulnerabilities enhancing hypomethylating agents in myeloid malignancies have remained elusive. RNA-interference drug modifier screens…”
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Prognostic value of chromosome 1q21 gain by fluorescent in situ hybridization and increase CKS1B expression in myeloma by FONSECA, R, VAN WIER, S. A, PRICE-TROSKA, T, HENDERSON, K. J, AHMANN, G. J, GERTZ, M. A, CHNG, W. J, KETTERLING, R, LACY, M. Q, DISPENZIERI, A, BERGSAGEL, P. L, RAJKUMAR, S. V, GREIPP, P. R, LITZOW, M. R

“…A specific role for increased level of expression of CKS1B, as a consequence of chromosome 1q21 copy number gain, has been postulated as both pathogenic, as…”
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Prognostic factors for hyperdiploid-myeloma: effects of chromosome 13 deletions and IgH translocations by CHNG, W. J, SANTANA-DAVILA, R, OKEN, M. M, HENDERSON, K, KYLE, R. A, GERTZ, M. A, LACY, M. Q, DISPENZIERI, A, GREIPP, P. R, FONSECA, R, VAN WIER, S. A, AHMANN, G. J, JALAL, S. M, BERGSAGEL, P. L, CHESI, M, TRENDLE, M. C, JACOBUS, S, BLOOD, E

“…Chromosomal hyperdiploidy is the defining genetic signature in 40-50% of myeloma (MM) patients. We characterize hyperdiploid-MM (H-MM) in terms of its clinical…”
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Hypodiploid multiple myeloma is characterized by more aggressive molecular markers than non-hyperdiploid multiple myeloma by Van Wier, Scott, Braggio, Esteban, Baker, Angela, Ahmann, Gregory, Levy, Joan, Carpten, John D, Fonseca, Rafael

“…Multiple myeloma can be categorized into hyperdiploid or non-hyperdiploid myeloma based on the number of chromosomes found in the tumor clone. Among the…”
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Longitudinal analysis of 25 sequential sample-pairs using a custom multiple myeloma mutation sequencing panel (M3P) by Kortüm, K. M., Langer, C., Monge, J., Bruins, L., Zhu, Y. X., Shi, C. X., Jedlowski, P., Egan, J. B., Ojha, J., Bullinger, L., Kull, M., Ahmann, G., Rasche, L., Knop, S, Fonseca, R., Einsele, H., Stewart, A. K., Braggio, Esteban

“…Recent advances in genomic sequencing technologies now allow results from deep next-generation sequencing to be obtained within clinically meaningful…”
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Panel sequencing for clinically oriented variant screening and copy number detection in 142 untreated multiple myeloma patients by Kortuem, K M, Braggio, E, Bruins, L, Barrio, S, Shi, C S, Zhu, Y X, Tibes, R, Viswanatha, D, Votruba, P, Ahmann, G, Fonseca, R, Jedlowski, P, Schlam, I, Kumar, S, Bergsagel, P L, Stewart, A K

“…We employed a customized Multiple Myeloma (MM)-specific Mutation Panel (M 3 P) to screen a homogenous cohort of 142 untreated MM patients for relevant…”
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Targeted sequencing of relapsed/refractory myeloma patients identifies an enrichment of mutations in MAPK and Cereblon pathways by Kortüm, K.M, Mai, E.K, Hanafiah, N.H, Barrio, S, Bruins, L, Merz, M, Xu, J, Pashayeva, K, Zhu, Y.X, Shi, C.X, Jedlowski, P, Ahmann, G, Andrulis, M, Hillengass, J, Goldschmidt, H, Fonseca, R, Bergsagel, P.L, Braggio, E, Raab, M.S, Stewart, A.K

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Diagnostic evaluation of t(4;14) in multiple myeloma and evidence for clonal evolution by Stewart, A K, Chang, H, Trudel, S, Anderson, K C, Richardson, P, Alsina, M, Reece, D, Young, S, Sable-Hunt, A, Li, Z, Keats, J, Van Wier, S, Ahmann, G, Price-Troska, T, Giusti, K, Bergsagel, P L, Chesi, M, Fonseca, R

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Systemic therapy of myeloma xenografts by an attenuated measles virus by Peng, Kah-Whye, Ahmann, Gregory J., Pham, Linh, Greipp, Philip R., Cattaneo, Roberto, Russell, Stephen J.

“…Conditionally replicating viruses are promising agents for the treatment of malignancy. Here it is shown that the live attenuated Edmonston-B vaccine strain of…”
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Ploidy status rarely changes in myeloma patients at disease progression by Chng, W.J., Winkler, J.M., Greipp, P.R., Jalal, S.M., Bergsagel, P.L., Chesi, M., Trendle, M.C., Ahmann, G.J., Henderson, K., Blood, E., Oken, M.M., Hulbert, A., Wier, S.A. Van, Santana-Dávila, R., Kyle, R.A., Gertz, M.A., Lacy, M.Q., Dispenzieri, A., Fonseca, R.

“…Hyperdiploid and non-hyperdiploid multiple myeloma represents distinct biological entities characterized by different patterns of genetic changes. We sought to…”
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Establishment and characterization of three myeloma cell lines that demonstrate variable cytokine responses and abilities to produce autocrine interleukin-6 by Westendorf, J J, Ahmann, G J, Greipp, P R, Witzig, T E, Lust, J A, Jelinek, D F

“…A consensus regarding myeloma cell growth factor responsiveness and ability to produce autocrine interleukin (IL)-6 has not yet been obtained. In this study,…”
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Translocations involving the immunoglobulin heavy-chain locus are possible early genetic events in patients with primary systemic amyloidosis by Hayman, Suzanne R., Bailey, Richard J., Jalal, Syed M., Ahmann, Gregory J., Dispenzieri, Angela, Gertz, Morie A., Greipp, Philip R., Kyle, Robert A., Lacy, Martha Q., Rajkumar, S. Vincent, Witzig, Thomas E., Lust, John A., Fonseca, Rafael

“…Primary systemic amyloidosis (AL) is a plasma cell (PC) dyscrasia with clinical similarities to multiple myeloma (MM) and monoclonal gammopathy of undetermined…”
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Contrast in cytokine expression between patients with monoclonal gammopathy of undetermined significance or multiple myeloma by DONOVAN, K. A, LACY, M. Q, KLINE, M. P, AHMANN, G. J, HEIMBACH, J. K, KYLE, R. A, LUST, J. A

“…We investigated whether differences in IL-6 and IL-1beta expression could be detected in monoclonal plasma cells from patients with MGUS or MM. Expression of…”
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CD40 expression in malignant plasma cells : role in stimulation of autocrine IL-6 secretion by a human myeloma cell line by WESTENDORF, J. J, AHMANN, G. J, ARMITAGE, R. J, SPRIGGS, M. K, LUST, J. A, GREIPP, P. R, KATZMANN, J. A, JELINEK, D. F

“…Myeloma is a neoplasia characterized by the accumulation of malignant plasma cells in the bone marrow. In these studies, we have demonstrated that CD40 is…”
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Chromosomal abnormalities in systemic amyloidosis by Fonseca, Rafael, Ahmann, Gregory J., Jalal, Syed M., Dewald, Gordon W., Larson, Dirk R., Therneau, Terry M., Gertz, Morie A., Kyle, Robert A., Greipp, Philip R.

“…Primary systemic amyloidosis (AL) is a plasma cell disorder characterized by deposition of monoclonal light chains in different organ systems. Although…”
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MYC dysregulation in the progression of multiple myeloma by Misund, Kristine, Keane, Niamh, Stein, Caleb K., Asmann, Yan W., Day, Grady, Welsh, Seth, Van Wier, Scott A., Riggs, Daniel L., Ahmann, Greg, Chesi, Marta, Viswanatha, David S., Kumar, Shaji K., Dispenzieri, Angela, Gonzalez-Calle, Veronica, Kyle, Robert A., O’Dwyer, Michael, Rajkumar, S. Vincent, Kortüm, K. Martin, Keats, J. Jonathan, Fonseca, Rafael, Stewart, A. Keith, Kuehl, W. Michael, Braggio, Esteban, Bergsagel, P. Leif

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Coexistence of aneuploid subclones within a myeloma cell line that exhibits clonal immunoglobulin gene rearrangement : clinical implications by JELINEK, D. F, AHMANN, G. J, GREIPP, P. R, JALAL, S. M, WESTENDORF, J. J, KATZMANN, J. A, KYLE, R. A, LUST, J. A

“…A new human myeloma cell line, ANBL-6, was established and characterized at the genotypic and phenotypic levels. The cells exhibit a clonally rearranged…”
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FISH Demonstrates Treatment-Related Chromosome Damage in Myeloid but not Plasma Cells in Primary Systemic Amyloidosis by Fonseca, Rafael, Rajkumar, S. Vincent, Ahmann, Gregory J., Jalal, Syed M., Hoyer, James D., Gertz, Morie A., Kyle, Robert A., Greipp, Philip R., Dewald, Gordon W.

“…Conventional cytogenetic analysis is limited in the evaluation of plasma cell disorders because, relative to normal hematopoietic elements, plasma cells divide…”
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Plasma interleukin-6 and C-reactive protein levels in reactive versus clonal thrombocytosis by Tefferi, A, Ho, T C, Ahmann, G J, Katzmann, J A, Greipp, P R

“…Evaluate the discriminatory value of plasma interleukin-6 or C-reactive protein levels in clonal thrombocytosis compared with those in reactive thrombocytosis…”
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