Light-Harvesting Photosensitizers for Photodynamic Inactivation of Bacteria under Both Visible and Near-Infrared Excitations

We report a hybrid singlet oxygen production system, where strong resonance coupling between plasmonic nanoparticles and photosensitizing molecules results in exceptionally high singlet oxygen production under both visible light and near‐infrared light excitation, even for the photosensitizing molec...

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Bibliographic Details
Published in:	Chemistry, an Asian journal Vol. 11; no. 7; pp. 1092 - 1097
Main Authors:	Hu, Bo, Cao, Xian, Ahmadov, Ms. Tevhide Ozkaya, Ding, Rui, Tang, Hong, Zhang, Peng
Format:	Journal Article
Language:	English
Published:	Germany Blackwell Publishing Ltd 05-04-2016 Wiley Subscription Services, Inc
Subjects:	Acinetobacter baumannii - drug effects Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Chemistry Escherichia coli - drug effects Infrared Rays Light light-harvesting Metal Nanoparticles - chemistry Microbial Sensitivity Tests Oxygen photodynamic inactivation Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Photosensitizing Agents - radiation effects riboflavin Riboflavin - chemistry Riboflavin - pharmacology Silver - chemistry Silver - pharmacology silver nanoparticles singlet oxygen Singlet Oxygen - chemistry Staphylococcus epidermidis - drug effects silver nanoparticles singlet oxygen photodynamic inactivation light-harvesting riboflavin
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Summary:	We report a hybrid singlet oxygen production system, where strong resonance coupling between plasmonic nanoparticles and photosensitizing molecules results in exceptionally high singlet oxygen production under both visible light and near‐infrared light excitation, even for the photosensitizing molecules without near‐infrared absorption. The light‐harvesting property of the plasmon‐photosensitizer hybrids leads to an enhanced, broad‐spectrum photodynamic inactivation of bacteria under a wide range of excitations, including that with near‐infrared light. Only light can do that: A hybrid system consisting of plasmonic nanoparticles and photosensitizing molecules results in high singlet oxygen production under broadened excitation, and displays enhanced, broad‐spectrum photodynamic inactivation of bacteria under both visible and near‐infrared light illuminations.
Bibliography:	US DOD Award - No. W81XWH-11-2-0103 ark:/67375/WNG-762LQNWG-D istex:46006C26A1C2D56173F3AF8A45819D464AEEF146 ArticleID:ASIA201600071 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1861-4728 1861-471X
DOI:	10.1002/asia.201600071