Search Results - "Ahmadi, Malek"

Selective decline of neurotrophin and neurotrophin receptor genes within CA1 pyramidal neurons and hippocampus proper: Correlation with cognitive performance and neuropathology in mild cognitive impairment and Alzheimer's disease by Ginsberg, Stephen D., Malek‐Ahmadi, Michael H., Alldred, Melissa J., Che, Shaoli, Elarova, Irina, Chen, Yinghua, Jeanneteau, Freddy, Kranz, Thorsten M., Chao, Moses V, Counts, Scott E., Mufson, Elliott J.

“…Hippocampal CA1 pyramidal neurons, a major component of the medial temporal lobe memory circuit, are selectively vulnerable during the progression of…”
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HDAC2 dysregulation in the nucleus basalis of Meynert during the progression of Alzheimer's disease by Mahady, L., Nadeem, M., Malek‐Ahmadi, M., Chen, K., Perez, S. E., Mufson, E. J.

“…Aims Alzheimer's disease (AD) is characterized by degeneration of cholinergic basal forebrain (CBF) neurons in the nucleus basalis of Meynert (nbM), which…”
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Alzheimer's Disease Neuropathological Comorbidities are Common in the Younger-Old by Beach, Thomas G, Malek-Ahmadi, Michael

“…Clinicopathological studies have demonstrated that Alzheimer's disease dementia (ADD) is often accompanied by clinically undetectable comorbid…”
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Meta-analysis of Montreal cognitive assessment diagnostic accuracy in amnestic mild cognitive impairment by Malek-Ahmadi, Michael, Nikkhahmanesh, Nia

“…The Montreal Cognitive Assessment (MoCA) is one of the most widely-used cognitive screening instruments and has been translated into several different…”
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Oligomeric, phosphorylated, and truncated tau and spliceosome pathology within the entorhinal–hippocampal connectome across stages of Alzheimer's disease by Mahady, Laura J., Perez, Sylvia E., Malek‐Ahmadi, Michael, Mufson, Elliott J.

“…Neurofibrillary tangles (NFTs) contain abnormally phosphorylated tau proteins, which spread within components of the medial temporal lobe (MTL) memory circuit…”
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Challenging the relationship of grip strength with cognitive status in older adults by Hooyman, Andrew, Malek‐Ahmadi, Michael, Fauth, Elizabeth B., Schaefer, Sydney Y.

“…Objective Grip strength is a widely used motor assessment in ageing research and has repeatedly been shown to be associated with cognition. It has been…”
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Brain-derived neurotrophic factor (BDNF) and TrkB hippocampal gene expression are putative predictors of neuritic plaque and neurofibrillary tangle pathology by Ginsberg, Stephen D., Malek-Ahmadi, Michael H., Alldred, Melissa J., Chen, Yinghua, Chen, Kewei, Chao, Moses V., Counts, Scott E., Mufson, Elliott J.

“…Downregulation of brain-derived neurotrophic factor (BDNF) and its cognate neurotrophin receptor, TrkB, were observed during the progression of dementia, but…”
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Expression profiling of precuneus layer III cathepsin D‐immunopositive pyramidal neurons in mild cognitive impairment and Alzheimer's disease: Evidence for neuronal signaling vulnerability by He, Bin, Perez, Sylvia E., Lee, Sang H., Ginsberg, Stephen D., Malek‐Ahmadi, Michael, Mufson, Elliott J.

“…The precuneus (PreC; Brodmann area 7), a key hub within the default mode network (DMN) displays amyloid and tau‐containing neurofibrillary tangle (NFT)…”
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Telomeric alterations in the default mode network during the progression of Alzheimer’s disease: Selective vulnerability of the precuneus by Mahady, Laura J., He, Bin, Malek‐Ahmadi, Michael, Mufson, Elliott J.

“…Aims Although telomere length (TL) and telomere maintenance proteins (shelterins) are markers of cellular senescence and peripheral blood biomarkers of…”
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Neocortical and hippocampal TREM2 protein levels during the progression of Alzheimer’s disease by Perez, Sylvia E., PhD, Nadeem, Muhammad, MD, He, Bin, MD, Miguel, Jennifer C., PhD, Malek-Ahmadi, Michael H, Chen, Kewei, Mufson, Elliott J., PhD

“…Abstract Heterozygous TREM2 mutations are an Alzheimer’s disease (AD) risk factor. Non-mutated TREM2 dysregulation occurs in AD brain. Whether TREM2 is altered…”
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Frontal cortex chitinase and pentraxin neuroinflammatory alterations during the progression of Alzheimer's disease by Moreno-Rodriguez, Marta, Perez, Sylvia E, Nadeem, Muhammad, Malek-Ahmadi, Michael, Mufson, Elliott J

“…Chitinase 3-like 1 (CHI3L1), chitinase 3-like 2 (CHI3L2), and neuronal pentraxin II (NPTX2) are inflammatory biomarkers of Alzheimer's disease (AD). Although…”
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Volumetric regional MRI and neuropsychological predictors of motor task variability in cognitively unimpaired, Mild Cognitive Impairment, and probable Alzheimer's disease older adults by Malek-Ahmadi, Michael, Duff, Kevin, Chen, Kewei, Su, Yi, King, Jace B., Koppelmans, Vincent, Schaefer, Sydney Y.

“…The mechanisms linking motor function to Alzheimer's disease (AD) progression have not been well studied, despite evidence of AD pathology within motor brain…”
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Sex differences in cognitive resilience in preclinical autosomal‐dominant Alzheimer's disease carriers and non‐carriers: Baseline findings from the API ADAD Colombia Trial by Vila‐Castelar, Clara, Tariot, Pierre N., Sink, Kaycee M., Clayton, David, Langbaum, Jessica B., Thomas, Ronald G., Chen, Yinghua, Su, Yi, Chen, Kewei, Hu, Nan, Giraldo‐Chica, Margarita, Tobón, Carlos, Acosta‐Baena, Natalia, Luna, Ernesto, Londoño, Marisol, Ospina, Paula, Tirado, Victoria, Muñoz, Claudia, Henao, Eliana, Bocanegra, Yamile, Alvarez, Sergio, Rios‐Romenets, Silvia, Ghisays, Valentina, Goradia, Dhruman, Lee, Wendy, Luo, Ji, Malek‐Ahmadi, Michael H., Protas, Hillary D., Lopera, Francisco, Reiman, Eric M., Quiroz, Yakeel T.

“…Introduction Females may have greater susceptibility to Alzheimer's disease (AD)‐pathology. We examined the effect of sex on pathology, neurodegeneration, and…”
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Baseline demographic, clinical, and cognitive characteristics of the Alzheimer's Prevention Initiative (API) Autosomal‐Dominant Alzheimer's Disease Colombia Trial by Rios‐Romenets, Silvia, Lopera, Francisco, Sink, Kaycee M., Hu, Nan, Lian, Qinshu, Guthrie, Heather, Smith, Jillian, Cho, William, Mackey, Howard, Langbaum, Jessica B., Thomas, Ronald G., Giraldo‐Chica, Margarita, Tobon, Carlos, Acosta‐Baena, Natalia, Muñoz, Claudia, Ospina, Paula, Tirado, Victoria, Henao, Eliana, Bocanegra, Yamile, Chen, Kewei, Su, Yi, Goradia, Dhruman, Thiyyagura, Pradeep, VanGilder, Paul S., Luo, Ji, Ghisays, Valentina, Lee, Wendy, Malek‐Ahmadi, Michael H., Protas, Hillary D., Chen, Yinghua, Quiroz, Yakeel T., Reiman, Eric M., Tariot, Pierre N.

“…Introduction The API AutosomalDominant AD (ADAD) Colombia Trial is a placebo‐controlled clinical trial of crenezumab in 252 cognitively unimpaired 30 to…”
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Neurogenesis and neuronal differentiation in the postnatal frontal cortex in Down syndrome by Utagawa, Emma C, Moreno, David G, Schafernak, Kristian T, Arva, Nicoleta C, Malek-Ahmadi, Michael H, Mufson, Elliott J, Perez, Sylvia E

“…Although Down syndrome (DS), the most common developmental genetic cause of intellectual disability, displays proliferation and migration deficits in the…”
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Morphological and pathological evolution of the brain microcirculation in aging and Alzheimer's disease by Hunter, Jesse M, Kwan, Jason, Malek-Ahmadi, Michael, Maarouf, Chera L, Kokjohn, Tyler A, Belden, Christine, Sabbagh, Marwan N, Beach, Thomas G, Roher, Alex E

“…Key pathological hallmarks of Alzheimer's disease (AD), including amyloid plaques, cerebral amyloid angiopathy (CAA) and neurofibrillary tangles do not…”
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Differential effects of perceptions of equal, favourable and unfavourable autonomy support on educational and well-being outcomes by Chatzisarantis, Nikos L.D., Ada, Elif Nilay, Ahmadi, Malek, Caltabiano, Nerina, Wang, Deming, Thogersen-Ntoumani, Cecilie, Hagger, Martin S.

“…•Perceptions of equal autonomy support yield optimal levels of need satisfaction.•Equal autonomy support predicts enjoyment and course grades indirectly via…”
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Editorial: Vascular Factors and Vascular Lesions in Pre-clinical Alzheimer's Disease by Malek-Ahmadi, Michael, Su, Yi, Jansen, Willemijn J.

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Plasma NfL is associated with the APOE ε4 allele, brain imaging measurements of neurodegeneration, and lower recall memory scores in cognitively unimpaired late-middle-aged and older adults by Malek-Ahmadi, Michael, Su, Yi, Ghisays, Valentina, Luo, Ji, Devadas, Vivek, Chen, Yinghua, Lee, Wendy, Protas, Hillary, Chen, Kewei, Zetterberg, Henrik, Blennow, Kaj, Caselli, Richard J, Reiman, Eric M

“…Plasma neurofilament light (NfL) is an indicator of neurodegeneration and/or neuroaxonal injury in persons with Alzheimer's disease (AD) and a wide range of…”
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A public resource of baseline data from the Alzheimer's Prevention Initiative Autosomal‐Dominant Alzheimer's Disease Trial by Reiman, Eric M., Pruzin, Jeremy J., Rios‐Romenets, Silvia, Brown, Chris, Giraldo, Margarita, Acosta‐Baena, Natalia, Tobon, Carlos, Hu, Nan, Chen, Yinghua, Ghisays, Valentina, Enos, Jessica, Goradia, Dhruman D., Lee, Wendy, Luo, Ji, Malek‐Ahmadi, Michael, Protas, Hillary, Thomas, Ronald G., Chen, Kewei, Su, Yi, Boker, Connie, Mastroeni, Diego, Alvarez, Sergio, Quiroz, Yakeel T., Langbaum, Jessica B., Sink, Kaycee M., Lopera, Francisco, Tariot, Pierre N.

“…Introduction The Alzheimer's Prevention Initiative Autosomal‐Dominant Alzheimer's Disease (API ADAD) Trial evaluated the anti‐oligomeric amyloid beta (Aβ)…”
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