Search Results - "Ahmad, Shamaila"

Peripheral memory T cells specific for Arginase-1 by Martinenaite, Evelina, Ahmad, Shamaila Munir, Svane, Inge Marie, Andersen, Mads Hald

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Acquired Immune Resistance Follows Complete Tumor Regression without Loss of Target Antigens or IFNγ Signaling by Donia, Marco, Harbst, Katja, van Buuren, Marit, Kvistborg, Pia, Lindberg, Mattias F, Andersen, Rikke, Idorn, Manja, Munir Ahmad, Shamaila, Ellebæk, Eva, Mueller, Anja, Fagone, Paolo, Nicoletti, Ferdinando, Libra, Massimo, Lauss, Martin, Hadrup, Sine Reker, Schmidt, Henrik, Andersen, Mads Hald, Thor Straten, Per, Nilsson, Jonas A, Schumacher, Ton N, Seliger, Barbara, Jönsson, Göran, Svane, Inge Marie

“…Cancer immunotherapy can result in durable tumor regressions in some patients. However, patients who initially respond often experience tumor progression…”
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CCL22-specific T Cells: Modulating the immunosuppressive tumor microenvironment by Martinenaite, Evelina, Munir Ahmad, Shamaila, Hansen, Morten, Met, Özcan, Westergaard, Marie Wulff, Larsen, Stine Kiaer, Klausen, Tobias Wirenfeldt, Donia, Marco, Svane, Inge Marie, Andersen, Mads Hald

“…Tumor cells and tumor-infiltrating macrophages produce the chemokine CCL22, which attracts regulatory T cells (Tregs) into the tumor microenvironment,…”
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Peptide vaccination activating Galectin-3-specific T cells offers a novel means to target Galectin-3-expressing cells in the tumor microenvironment by Bendtsen, Simone Kloch, Perez-Penco, Maria, Hübbe, Mie Linder, Martinenaite, Evelina, Orebo Holmström, Morten, Weis-Banke, Stine Emilie, Grønne Dahlager Jørgensen, Nicolai, Jørgensen, Mia Aaboe, Munir Ahmad, Shamaila, Jensen, Kasper Mølgaard, Friese, Christina, Lundsager, Mia Thorup, Johansen, Astrid Zedlitz, Carretta, Marco, Ødum, Niels, Met, Özcan, Svane, Inge Marie, Madsen, Daniel Hargbøl, Andersen, Mads Hald

“…Galectin-3 (Gal3) can be expressed by many cells in the tumor microenvironment (TME), including cancer cells, cancer-associated fibroblasts, tumor-associated…”
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Arginase-1 specific CD8+ T cells react toward malignant and regulatory myeloid cells by Glöckner, Hannah Jorinde, Martinenaite, Evelina, Landkildehus Lisle, Thomas, Grauslund, Jacob, Ahmad, Shamaila, Met, Özcan, Thor Straten, Per, Hald Andersen, Mads

“…Arginase-1 (Arg1) is expressed by regulatory myeloid cells in the tumor microenvironment (TME), where they play a pro-tumorigenic and T-cell suppressive role…”
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Frequent adaptive immune responses against arginase-1 by Martinenaite, Evelina, Mortensen, Rasmus Erik Johansson, Hansen, Morten, Orebo Holmström, Morten, Munir Ahmad, Shamaila, Grønne Dahlager Jørgensen, Nicolai, Met, Özcan, Donia, Marco, Svane, Inge Marie, Andersen, Mads Hald

“…The enzyme arginase-1 reduces the availability of arginine to tumor-infiltrating immune cells, thus reducing T-cell functionality in the tumor milieu…”
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PD-L1 peptide co-stimulation increases immunogenicity of a dendritic cell-based cancer vaccine by Munir Ahmad, Shamaila, Martinenaite, Evelina, Hansen, Morten, Junker, Niels, Borch, Troels Holz, Met, Özcan, Donia, Marco, Svane, Inge Marie, Andersen, Mads Hald

“…We recently described naturally occurring PD-L1-specific T cells that recognize PD-L1-expressing immune cells as well as malignant cells. In the present study,…”
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High frequencies of circulating memory T cells specific for calreticulin exon 9 mutations in healthy individuals by Holmström, Morten O., Ahmad, Shamaila M., Klausen, Uffe, Bendtsen, Simone K., Martinenaite, Evelina, Riley, Caroline H., Svane, Inge M., Kjær, Lasse, Skov, Vibe, Ellervik, Christina, Pallisgaard, Niels, Hasselbalch, Hans C., Andersen, Mads H.

“…Mutations in exon 9 of the calreticulin gene ( CALR ) frequently occur in patients with chronic myeloproliferative neoplasms (MPN). Patients exhibit…”
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Arginase-1-based vaccination against the tumor microenvironment: the identification of an optimal T-cell epitope by Martinenaite, Evelina, Ahmad, Shamaila Munir, Bendtsen, Simone Kloch, Jørgensen, Mia Aaboe, Weis-Banke, Stine Emilie, Svane, Inge Marie, Andersen, Mads Hald

“…l -arginine depletion by regulatory cells and cancer cells expressing arginase-1 (Arg-1) is a vital contributor to the immunosuppressive tumor microenvironment…”
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Therapeutic cancer vaccination against mutant calreticulin in myeloproliferative neoplasms induces expansion of specific T cells in the periphery but specific T cells fail to enrich in the bone marrow by Holmström, Morten Orebo, Andersen, Morten, Traynor, Sofie, Ahmad, Shamaila Munir, Lisle, Thomas Landkildehus, Handlos Grauslund, Jacob, Skov, Vibe, Kjær, Lasse, Ottesen, Johnny T., Gjerstorff, Morten Frier, Hasselbalch, Hans Carl, Andersen, Mads Hald

“…Background Therapeutic cancer vaccination against mutant calreticulin ( CALR ) in patients with CALR -mutant ( CALR mut) myeloproliferative neoplasms (MPN)…”
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Peptide Vaccination Against PD-L1 With IO103 a Novel Immune Modulatory Vaccine in Multiple Myeloma: A Phase I First-in-Human Trial by Jørgensen, Nicolai Grønne, Klausen, Uffe, Grauslund, Jacob Handlos, Helleberg, Carsten, Aagaard, Thomas Granum, Do, Trung Hieu, Ahmad, Shamaila Munir, Olsen, Lars Rønn, Klausen, Tobias Wirenfeldt, Breinholt, Marie Fredslund, Hansen, Morten, Martinenaite, Evelina, Met, Özcan, Svane, Inge Marie, Knudsen, Lene Meldgaard, Andersen, Mads Hald

“…Immune checkpoint blockade with monoclonal antibodies targeting programmed death 1 (PD-1) and its ligand PD-L1 has played a major role in the rise of cancer…”
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The inhibitory checkpoint, PD-L2, is a target for effector T cells: Novel possibilities for immune therapy by Ahmad, Shamaila Munir, Martinenaite, Evelina, Holmström, Morten, Jørgensen, Mia Aaboe, Met, Özcan, Nastasi, Claudia, Klausen, Uffe, Donia, Marco, Pedersen, Lars Møller, Munksgaard, Lars, Ødum, Niels, Woetmann, Anders, Svane, Inge Marie, Andersen, Mads Hald

“…Cell surface molecules of the B7/CD28 family play an important role in T-cell activation and tolerance. The relevance of the PD-1/PD-L1 pathway in cancer has…”
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Staphylococcus aureus alpha-toxin inhibits CD8 + T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma by Blümel, Edda, Munir Ahmad, Shamaila, Nastasi, Claudia, Willerslev-Olsen, Andreas, Gluud, Maria, Fredholm, Simon, Hu, Tengpeng, Surewaard, Bas G J, Lindahl, Lise M, Fogh, Hanne, Koralov, Sergei B, Rahbek Gjerdrum, Lise Mette, Clark, Rachael A, Iversen, Lars, Krejsgaard, Thorbjørn, Bonefeld, Charlotte Menné, Geisler, Carsten, Becker, Jürgen C, Woetmann, Anders, Andersen, Mads Hald, Buus, Terkild Brink, Ødum, Niels

“…and its toxins have been linked to disease progression and mortality in advanced stages of cutaneous T-cell lymphoma (CTCL). CD8 T cells play a crucial role in…”
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Anti-PD-L1/PD-L2 therapeutic vaccination in untreated chronic lymphocytic leukemia patients with unmutated IgHV by Klausen, Uffe, Grauslund, Jacob Handlos, Jørgensen, Nicolai Grønne Dahlager, Ahmad, Shamaila Munir, Jonassen, Merete, Weis-Banke, Stine Emilie, Martinenaite, Evelina, Pedersen, Lone Bredo, Lisle, Thomas Landkildehus, Gang, Anne Ortved, Enggaard, Lisbeth, Hansen, Morten, Holmström, Morten Orebo, Met, Özcan, Svane, Inge Marie, Niemann, Carsten Utoft, Pedersen, Lars Møller, Andersen, Mads Hald

“…Chronic lymphocytic leukemia (CLL) patients with unmutated immunoglobulin heavy chain (IgHV) are at risk of early disease progression compared to patients with…”
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An immunogenic first-in-human immune modulatory vaccine with PD-L1 and PD-L2 peptides is feasible and shows early signs of efficacy in follicular lymphoma by Klausen, Uffe, Grønne Dahlager Jørgensen, Nicolai, Grauslund, Jacob Handlos, Munir Ahmad, Shamaila, Gang, Anne Ortved, Martinenaite, Evelina, Weis-Banke, Stine Emilie, Breinholt, Marie Fredslund, Novotny, Guy Wayne, Kjeldsen, Julie Westerlin, Orebo Holmström, Morten, Pedersen, Lone Bredo, Poulsen, Christian Bjørn, Hansen, Per Boye, Met, Özcan, Svane, Inge Marie, Niemann, Carsten Utoft, Pedersen, Lars Møller, Andersen, Mads Hald

“…Cells in the tumor microenvironment of Follicular lymphoma (FL) express checkpoint molecules such as programmed death ligands 1 and 2 (PD-L1 and PD-L2) and are…”
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778 Modulating tumor microenvironment with arginase-1 specific T cells by Martinenaite, Evelina, Jørgensen, Mia Aaboe, Johansson Mortensen, Rasmus Erik, Ahmad, Shamaila Munir, Weis-Banke, Stine Emilie, Holmström, Morten Orebo, Pedersen, Ayako Wakatsuki, Met, Özcan, Svane, Inge, Andersen, Mads Hald

“…BackgroundIO112 is an immune modulatory cancer therapy under preclinical development to target arginase-1-expressing tumor cells and immune inhibitory myeloid…”
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PD-L1-specific T cells by Ahmad, Shamaila Munir, Borch, Troels Holz, Hansen, Morten, Andersen, Mads Hald

“…Recently, there has been an increased focus on the immune checkpoint protein PD-1 and its ligand PD-L1 due to the discovery that blocking the PD-1/PD-L1…”
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Abstract 4094: Immune modulatory cancer vaccines against IDO1 and PD-L1 trigger distinct pathways and cooperatively reduce tumor growth in preclinical models by Chapellier, Marion, Martinenaite, Evelina, Patel, Preeyam, Svendsen, Lea, Ahmad, Shamaila Munir, Glöckner, Hannah Jorinde, Carretta, Marco, Sutanto-Ward, Erika, DuHadaway, James, Dey, Souvik, Shen, Shih-Chun, Ghaban, Dema, Iglesias, Marcos, Biller, Megan, Lecoq, Inés, Muller, Alexander J., Andersen, Mads Hald, Pedersen, Ayako Wakatsuki

“…Abstract While immune checkpoint inhibitors have shown clinical efficacy in many cancers, drug and immune resistance remain challenging. Indoleamine…”
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Tryptophan 2,3-dioxygenase (TDO)-reactive T cells differ in their functional characteristics in health and cancer by Hjortsø, Mads Duus, Larsen, Stine Kiaer, Kongsted, Per, Met, Özcan, Frøsig, Thomas Mørch, Andersen, Gitte Holmen, Ahmad, Shamaila Munir, Svane, Inge Marie, Becker, Jürgen C, Straten, Per thor, Andersen, Mads Hald

“…Tryptophan-2,3-dioxygenase (TDO) physiologically regulates systemic tryptophan levels in the liver. However, numerous studies have linked cancer with…”
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Peptide vaccination against multiple myeloma using peptides derived from anti-apoptotic proteins: a phase I trial by Jørgensen, Nicolai Grønne, Ahmad, Shamaila Munir, Abildgaard, Niels, Straten, Per Thor, Svane, Inge Marie, Andersen, Mads Hald, Knudsen, Lene Meldgaard

“…The B-cell lymphoma-2 (Bcl-2) family of proteins play a crucial role in multiple myeloma (MM), contributing to lacking apoptosis which is a hallmark of the…”
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