Search Results - "Ahmad, Sadeem"

An origin of the immunogenicity of in vitro transcribed RNA by Mu, Xin, Greenwald, Emily, Ahmad, Sadeem, Hur, Sun

“…Abstract The emergence of RNA-based therapeutics demands robust and economical methods to produce RNA with few byproducts from aberrant activity. While in…”
Get full text

Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation by Ahmad, Sadeem, Mu, Xin, Yang, Fei, Greenwald, Emily, Park, Ji Woo, Jacob, Etai, Zhang, Cheng-Zhong, Hur, Sun

“…Aberrant activation of innate immune receptors can cause a spectrum of immune disorders, such as Aicardi-Goutières syndrome (AGS). One such receptor is MDA5, a…”
Get full text

Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases by Kato, Kazuki, Ahmad, Sadeem, Zhu, Zixiang, Young, Janet M., Mu, Xin, Park, Sehoon, Malik, Harmit S., Hur, Sun

“…RNA helicases and E3 ubiquitin ligases mediate many critical functions in cells, but their actions have largely been studied in distinct biological contexts…”
Get full text

Recognition of Arabic handwritten characters using residual neural networks by al-Taani, Ahmad T., Ahmad, Sadim T.

“…This study proposes the use of Residual Neural Networks (ResNets) to recognize Arabic offline isolated handwritten characters including Arabic digits. ResNets…”
Get full text

Viral RNA N 6-methyladenosine modification modulates both innate and adaptive immune responses of human respiratory syncytial virus by Xue, Miaoge, Zhang, Yuexiu, Wang, Haitao, Kairis, Elizabeth L, Mijia Lu, Sadeem Ahmad, Zayed Attia, Olivia Harder, Zhang, Zijie, Wei, Jiangbo, Chen, Phylip, Gao, Youling, Mark E. Peeples, Sharma, Amit, Boyaka, Prosper, He, Chuan, Sun Hur, Stefan Niewiesk, Jianrong Li

“…Human respiratory syncytial virus (RSV) is the leading cause of respiratory tract infections in humans. A well-known challenge in the development of a live…”
Get full text

Elongation Factor Tu Prevents Misediting of Gly-tRNA(Gly) Caused by the Design Behind the Chiral Proofreading Site of D-Aminoacyl-tRNA Deacylase by Routh, Satya Brata, Pawar, Komal Ishwar, Ahmad, Sadeem, Singh, Swati, Suma, Katta, Kumar, Mantu, Kuncha, Santosh Kumar, Yadav, Kranthikumar, Kruparani, Shobha P, Sankaranarayanan, Rajan

“…D-aminoacyl-tRNA deacylase (DTD) removes D-amino acids mischarged on tRNAs and is thus implicated in enforcing homochirality in proteins. Previously, we…”
Get full text

Viral RNA N6-methyladenosine modification modulates both innate and adaptive immune responses of human respiratory syncytial virus by Xue, Miaoge, Zhang, Yuexiu, Wang, Haitao, Kairis, Elizabeth L, Lu, Mijia, Ahmad, Sadeem, Attia, Zayed, Harder, Olivia, Zhang, Zijie, Wei, Jiangbo, Chen, Phylip, Gao, Youling, Peeples, Mark E, Sharma, Amit, Boyaka, Prosper, He, Chuan, Hur, Sun, Niewiesk, Stefan, Li, Jianrong

“…Human respiratory syncytial virus (RSV) is the leading cause of respiratory tract infections in humans. A well-known challenge in the development of a live…”
Get full text

Mechanism of chiral proofreading during translation of the genetic code by Ahmad, Sadeem, Routh, Satya Brata, Kamarthapu, Venu, Chalissery, Jisha, Muthukumar, Sowndarya, Hussain, Tanweer, Kruparani, Shobha P, Deshmukh, Mandar V, Sankaranarayanan, Rajan

“…The biological macromolecular world is homochiral and effective enforcement and perpetuation of this homochirality is essential for cell survival. In this…”
Get full text

Convolutional Neural Network Based Approval Prediction of Enhancement Reports by Cheng, Jun, Sadiq, Mazhar, Kalugina, Olga A., Nafees, Sadeem Ahmad, Umer, Qasim

“…For a given software enhancement report, identifying its possible approval status could help software developers by suggesting feature enhancements to compete…”
Get full text

Specificity and catalysis hardwired at the RNA–protein interface in a translational proofreading enzyme by Ahmad, Sadeem, Muthukumar, Sowndarya, Kuncha, Santosh Kumar, Routh, Satya Brata, Yerabham, Antony S.K., Hussain, Tanweer, Kamarthapu, Venu, Kruparani, Shobha P, Sankaranarayanan, Rajan

“…Proofreading modules of aminoacyl-tRNA synthetases are responsible for enforcing a high fidelity during translation of the genetic code. They use strategically…”
Get full text

Helicases in Antiviral Immunity: Dual Properties as Sensors and Effectors by Ahmad, Sadeem, Hur, Sun

“…Many helicases have a unique ability to couple cognate RNA binding to ATP hydrolysis, which can induce a large conformational change that affects its…”
Get full text

N6-Methyladenosine Modification Controls Circular RNA Immunity by Chen, Y. Grace, Chen, Robert, Ahmad, Sadeem, Verma, Rohit, Kasturi, Sudhir Pai, Amaya, Laura, Broughton, James P., Kim, Jeewon, Cadena, Cristhian, Pulendran, Bali, Hur, Sun, Chang, Howard Y.

“…Circular RNAs (circRNAs) are prevalent in eukaryotic cells and viral genomes. Mammalian cells possess innate immunity to detect foreign circRNAs, but the…”
Get full text

Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity by Cadena, Cristhian, Ahmad, Sadeem, Xavier, Audrey, Willemsen, Joschka, Park, Sehoon, Park, Ji Woo, Oh, Seong-Wook, Fujita, Takashi, Hou, Fajian, Binder, Marco, Hur, Sun

“…The conventional view posits that E3 ligases function primarily through conjugating ubiquitin (Ub) to their substrate molecules. We report here that RIPLET, an…”
Get full text

ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation by de Reuver, Richard, Verdonck, Simon, Dierick, Evelien, Nemegeer, Josephine, Hessmann, Eline, Ahmad, Sadeem, Jans, Maude, Blancke, Gillian, Van Nieuwerburgh, Filip, Botzki, Alexander, Vereecke, Lars, van Loo, Geert, Declercq, Wim, Hur, Sun, Vandenabeele, Peter, Maelfait, Jonathan

“…The RNA-editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) limits the accumulation of endogenous immunostimulatory double-stranded RNA (dsRNA) 1 . In…”
Get full text

The Role of RNA Editing in the Immune Response by Ahmad, Sadeem, Mu, Xin, Hur, Sun

“…The innate immune receptors in higher organisms have evolved to detect molecular signatures associated with pathogenic infection and trigger appropriate immune…”
Get more information

Stress granules are shock absorbers that prevent excessive innate immune responses to dsRNA by Paget, Max, Cadena, Cristhian, Ahmad, Sadeem, Wang, Hai-Tao, Jordan, Tristan X., Kim, Ehyun, Koo, Beechui, Lyons, Shawn M., Ivanov, Pavel, tenOever, Benjamin, Mu, Xin, Hur, Sun

“…Proper defense against microbial infection depends on the controlled activation of the immune system. This is particularly important for the RIG-I-like…”
Get full text

A Fuzzy Inference-Based Decision Support System for Disease Diagnosis by Alam, Talha Mahboob, Shaukat, Kamran, Khelifi, Adel, Aljuaid, Hanan, Shafqat, Malaika, Ahmed, Usama, Nafees, Sadeem Ahmad, Luo, Suhuai

“…Abstract Disease diagnosis is an exciting task due to many associated factors. Inaccuracy in the measurement of a patient’s symptoms and the medical expert’s…”
Get full text

Nonsegmented Negative-Sense RNA Viruses Utilize N 6 -Methyladenosine (m 6 A) as a Common Strategy To Evade Host Innate Immunity by Lu, Mijia, Xue, Miaoge, Wang, Hai-Tao, Kairis, Elizabeth L, Ahmad, Sadeem, Wei, Jiangbo, Zhang, Zijie, Liu, Qinzhe, Zhang, Yuexiu, Gao, Youling, Garcin, Dominique, Peeples, Mark E, Sharma, Amit, Hur, Sun, He, Chuan, Li, Jianrong

“…-Methyladenosine (m A) is the most abundant internal RNA modification catalyzed by host RNA methyltransferases. As obligate intracellular parasites, many…”
Get full text

Viral RNA N.sup.6-methyladenosine modification modulates both innate and adaptive immune responses of human respiratory syncytial virus by Xue, Miaoge, Zhang, Yuexiu, Wang, Haitao, Kairis, Elizabeth L, Lu, Mijia, Ahmad, Sadeem, Attia, Zayed, Harder, Olivia, Zhang, Zijie, Wei, Jiangbo, Chen, Phylip, Gao, Youling, Peeples, Mark E, Sharma, Amit, Boyaka, Prosper, He, Chuan, Hur, Sun, Niewiesk, Stefan, Li, Jianrong

“…Human respiratory syncytial virus (RSV) is the leading cause of respiratory tract infections in humans. A well-known challenge in the development of a live…”
Get full text

Nonsegmented Negative-Sense RNA Viruses Utilize N6-Methyladenosine (m6A) as a Common Strategy To Evade Host Innate Immunity by Lu, Mijia, Xue, Miaoge, Wang, Hai-Tao, Kairis, Elizabeth L, Ahmad, Sadeem, Wei, Jiangbo, Zhang, Zijie, Liu, Qinzhe, Zhang, Yuexiu, Gao, Youling, Garcin, Dominique, Peeples, Mark E, Sharma, Amit, Hur, Sun, He, Chuan, Li, Jianrong

“…N6-Methyladenosine (m6A) is the most abundant internal RNA modification catalyzed by host RNA methyltransferases. As obligate intracellular parasites, many…”
Get full text