Search Results - "Ahmad, Rili"

Formation of a Stabilized Cysteine Sulfinic Acid Is Critical for the Mitochondrial Function of the Parkinsonism Protein DJ-1 by Blackinton, Jeff, Lakshminarasimhan, Mahadevan, Thomas, Kelly J., Ahmad, Rili, Greggio, Elisa, Raza, Ashraf S., Cookson, Mark R., Wilson, Mark A.

“…The formation of cysteine-sulfinic acid has recently become appreciated as a modification that links protein function to cellular oxidative status. Human DJ-1,…”
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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin by Greggio, Elisa, Jain, Shushant, Kingsbury, Ann, Bandopadhyay, Rina, Lewis, Patrick, Kaganovich, Alice, van der Brug, Marcel P., Beilina, Alexandra, Blackinton, Jeff, Thomas, Kelly Jean, Ahmad, Rili, Miller, David W., Kesavapany, Sashi, Singleton, Andrew, Lees, Andrew, Harvey, Robert J., Harvey, Kirsten, Cookson, Mark R.

“…Mutations in the LRRK2 gene, coding for dardarin, cause dominantly inherited Parkinson's disease (PD). Dardarin is a large protein, and mutations are found…”
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The Parkinson's Disease Protein DJ-1 Is Neuroprotective Due to Cysteine-Sulfinic Acid-Driven Mitochondrial Localization by Canet-Avilés, Rosa M., Wilson, Mark A., Miller, David W., Ahmad, Rili, McLendon, Chris, Bandyopadhyay, Sourav, Baptista, Melisa J., Ringe, Dagmar, Petsko, Gregory A., Cookson, Mark R.

“…Loss-of-function DJ-1 mutations can cause early-onset Parkinson's disease. The function of DJ-1 is unknown, but an acidic isoform accumulates after oxidative…”
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Mutations in PTEN-Induced Putative Kinase 1 Associated with Recessive Parkinsonism Have Differential Effects on Protein Stability by Beilina, Alexandra, Van Der Brug, Marcel, Ahmad, Rili, Kesavapany, Sashi, Miller, David W., Petsko, Gregory A., Cookson, Mark R.

“…Several mutations in PTEN-induced putative kinase 1 (PINK1) gene have been reported to be associated with recessive parkinsonism. The encoded protein is…”
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Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1 by Sandebring, Anna, Thomas, Kelly Jean, Beilina, Alexandra, van der Brug, Marcel, Cleland, Megan M, Ahmad, Rili, Miller, David W, Zambrano, Ibardo, Cowburn, Richard F, Behbahani, Homira, Cedazo-Mínguez, Angel, Cookson, Mark R

“…PTEN-induced novel kinase 1 (PINK1) mutations are associated with autosomal recessive parkinsonism. Previous studies have shown that PINK1 influences both…”
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RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways by van der Brug, Marcel P, Blackinton, Jeff, Chandran, Jayanth, Hao, Ling-Yang, Lal, Ashish, Mazan-Mamczarz, Krystyna, Martindale, Jennifer, Xie, Chengsong, Ahmad, Rili, Thomas, Kelly J, Beilina, Alexandra, Gibbs, J. Raphael, Ding, Jinhui, Myers, Amanda J, Zhan, Ming, Cai, Huaibin, Bonini, Nancy M, Gorospe, Myriam, Cookson, Mark R

“…Parkinson's disease (PD) is a major neurodegenerative condition with several rare Mendelian forms. Oxidative stress and mitochondrial function have been…”
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L166P Mutant DJ-1, Causative for Recessive Parkinson's Disease, Is Degraded through the Ubiquitin-Proteasome System by Miller, David W., Ahmad, Rili, Hague, Stephen, Baptista, Melisa J., Canet-Aviles, Rosa, McLendon, Chris, Carter, Donald M., Zhu, Peng-Peng, Stadler, Julia, Chandran, Jayanth, Klinefelter, Gary R., Blackstone, Craig, Cookson, Mark R.

“…Mutations in a gene on chromosome 1, DJ-1, have been reported recently to be associated with recessive, earlyonset Parkinson's disease. While one mutation is a…”
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Effects of DJ-1 mutations and polymorphisms on protein stability and subcellular localization by Blackinton, Jeff, Ahmad, Rili, Miller, David W., van der Brug, Marcel P., Canet-Avilés, Rosa M., Hague, Stephen M., Kaleem, Mona, Cookson, Mark R.

“…Mutations in the DJ-1 gene are associated with recessive, early onset Parkinson's disease (PD). We reported previously that one of the point mutations, L166P,…”
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Transcriptomic Profiling of Extracellular RNAs Present in Cerebrospinal Fluid Identifies Differentially Expressed Transcripts in Parkinson's Disease by Hossein-Nezhad, Arash, Fatemi, Roya Pedram, Ahmad, Rili, Peskind, Elaine R, Zabetian, Cyrus P, Hu, Shu-Ching, Shi, Min, Wahlestedt, Claes, Zhang, Jing, Faghihi, Mohammad Ali

“…Parkinson's disease (PD) is a debilitating neurological disorder for which prognostic and diagnostic biomarkers are lacking. Cerebrospinal fluid (CSF) is an…”
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Post-transcriptional regulation of mRNA associated with DJ-1 in sporadic Parkinson disease by Blackinton, Jeff, Kumaran, Ravindran, van der Brug, Marcel P., Ahmad, Rili, Olson, Lars, Galter, Dagmar, Lees, Andrew, Bandopadhyay, Rina, Cookson, Mark R.

“…Mutations in DJ-1 lead to a monogenic form of early onset recessive parkinsonism. DJ-1 can respond to oxidative stress, which has been proposed to be involved…”
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Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1 by Greggio, Elisa, Lewis, Patrick A, van der Brug, Marcel P, Ahmad, Rili, Kaganovich, Alice, Ding, Jinhui, Beilina, Alexandra, Baker, Acacia K, Cookson, Mark R

“…Several mutations have been found in the leucine-rich repeat kinase 2 gene (LRRK2), encoding the protein dardarin, which are associated with autosomal dominant…”
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Co‐ordinate transcriptional regulation of dopamine synthesis genes by α‐synuclein in human neuroblastoma cell lines by Baptista, Melisa J., O'Farrell, Casey, Daya, Sneha, Ahmad, Rili, Miller, David W., Hardy, John, Farrer, Matthew J., Cookson, Mark R.

“…Abnormal accumulation of α‐synuclein in Lewy bodies is a neuropathological hallmark of both sporadic and familial Parkinson's disease (PD). Although mutations…”
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Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease by Greggio, Elisa, Bergantino, Elisabetta, Carter, Donald, Ahmad, Rili, Costin, Gertrude‐Emilia, Hearing, Vincent J., Clarimon, Jordi, Singleton, Andrew, Eerola, Johanna, Hellström, Olli, Tienari, Pentti J., Miller, David W., Beilina, Alexandra, Bubacco, Luigi, Cookson, Mark R.

“…Tyrosinase is a key enzyme in the synthesis of melanin in skin and hair and has also been proposed to contribute to the formation of neuromelanin (NM). The…”
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Mutations in LRRK2dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1 by Greggio, Elisa, Lewis, Patrick A, van der Brug, Marcel P, Ahmad, Rili, Kaganovich, Alice, Ding, Jinhui, Beilina, Alexandra, Baker, Acacia K, Cookson, Mark R

“…Several mutations have been found in the leucine-rich repeat kinase 2 gene (LRRK2), encoding the protein dardarin, which are associated with autosomal dominant…”
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Effects of DJ-1 mutations and polymorphisms on protein stability and subcellular localization: Molecular mechanisms in Parkinson's disease by BLACKINTON, Jeff, AHMAD, Rili, MILLER, David W, VAN DER BRUG, Marcel P, CANET-AVILES, Rosa M, HAGUE, Stephen M, KALEEM, Mona, COOKSON, Mark R

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