Search Results - "Ahmad, Md Faiz"

Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization by Dealwis, Chris Godfrey, Fairman, James Wesley, Wijerathna, Sanath Ranjan, Ahmad, Md Faiz, Xu, Hai, Nakano, Ryo, Jha, Shalini, Prendergast, Jay, Welin, R Martin, Flodin, Susanne, Roos, Annette, Nordlund, Pär, Li, Zongli, Walz, Thomas

“…Ribonucleotide reductase is essential to maintain the cellular pools of dNTPs, and its activity is controlled allosterically by ATP (activator) and dATP…”
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Histidine hydrogen-deuterium exchange mass spectrometry for probing the microenvironment of histidine residues in dihydrofolate reductase by Miyagi, Masaru, Wan, Qun, Ahmad, Md Faiz, Gokulrangan, Giridharan, Tomechko, Sara E, Bennett, Brad, Dealwis, Chris

“…Histidine Hydrogen-Deuterium Exchange Mass Spectrometry (His-HDX-MS) determines the HDX rates at the imidazole C(2)-hydrogen of histidine residues. This method…”
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Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy by Wijerathna, Sanath R, Ahmad, Md Faiz, Xu, Hai, Fairman, James W, Zhang, Andrew, Kaushal, Prem Singh, Wan, Qun, Kiser, Jianying, Dealwis, Chris G

“…Ribonucleotide reductase (RR) is a crucial enzyme in de novo DNA synthesis, where it catalyses the rate determining step of dNTP synthesis. RRs consist of a…”
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Influence of Compensation, Performance Feedback on Employee Retention in Indian Retail Sector by Khan, Mohammed Arshad, Farooqi, Md Rashid, Ahmad, Md Faiz, Haque, Serajul, Alkhuraydili, Abdulaziz

“…The present article investigates the influence of compensation plans – financial as well as nonfinancial and performance feedback – with respect to the…”
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Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule by Ahmad, Md. Faiz, Alam, Intekhab, Huff, Sarah E., Pink, John, Flanagan, Sheryl A., Shewach, Donna, Misko, Tessianna A., Oleinick, Nancy L., Harte, William E., Viswanathan, Rajesh, Harris, Michael E., Dealwis, Chris Godfrey

“…Human ribonucleotide reductase (hRR) is crucial for DNA replication and maintenance of a balanced dNTP pool, and is an established cancer target. Nucleoside…”
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Phylogenetic sequence analysis and functional studies reveal compensatory amino acid substitutions in loop 2 of human ribonucleotide reductase by Knappenberger, Andrew J., Grandhi, Sneha, Sheth, Reena, Ahmad, Md. Faiz, Viswanathan, Rajesh, Harris, Michael E.

“…Eukaryotic class I ribonucleotide reductases (RRs) generate deoxyribonucleotides for DNA synthesis. Binding of dNTP effectors is coupled to the formation of…”
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Effect of Phosphorylation on αB-crystallin: Differences in Stability, Subunit Exchange and Chaperone Activity of Homo and Mixed Oligomers of αB-Crystallin and its Phosphorylation-mimicking Mutant by Ahmad, Md. Faiz, Raman, Bakthisaran, Ramakrishna, Tangirala, Rao, Ch. Mohan

“…Phosphorylation appears to be one of the modulators of chaperone functions of small heat shock proteins. However, the role of phosphorylation is not completely…”
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Nucleoside Analogue Triphosphates Allosterically Regulate Human Ribonucleotide Reductase and Identify Chemical Determinants That Drive Substrate Specificity by Knappenberger, Andrew J, Ahmad, Md. Faiz, Viswanathan, Rajesh, Dealwis, Chris G, Harris, Michael E

“…Class I ribonucleotide reductase (RR) maintains balanced pools of deoxyribonucleotide substrates for DNA replication by converting ribonucleoside diphosphates…”
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Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators by Ahmad, Md. Faiz, Huff, Sarah E, Pink, John, Alam, Intekhab, Zhang, Andrew, Perry, Kay, Harris, Michael E, Misko, Tessianna, Porwal, Suheel K, Oleinick, Nancy L, Miyagi, Masaru, Viswanathan, Rajesh, Dealwis, Chris Godfrey

“…Ribonucleotide reductase (RR) catalyzes the rate-limiting step of dNTP synthesis and is an established cancer target. Drugs targeting RR are mainly nucleoside…”
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Inhibition of yeast ribonucleotide reductase by Sml1 depends on the allosteric state of the enzyme by Misko, Tessianna A., Wijerathna, Sanath R., Radivoyevitch, Tomas, Berdis, Anthony J., Ahmad, Md. Faiz, Harris, Michael E., Dealwis, Chris G.

“…Sml1 is an intrinsically disordered protein inhibitor of Saccharomyces cerevisiae ribonucleotide reductase (ScRR1), but its inhibition mechanism is poorly…”
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Fibrillogenic and Non-fibrillogenic Ensembles of SDS-bound Human α-Synuclein by Ahmad, Md. Faiz, Ramakrishna, Tangirala, Raman, Bakthisaran, Rao, Ch. Mohan

“…Fibril formation of α-synuclein is associated with several neurodegenerative diseases, including Parkinson's disease in humans. The anionic detergent sodium…”
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Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase by Ahmad, Md. Faiz, Kaushal, Prem Singh, Wan, Qun, Wijerathna, Sanath R., An, Xiuxiang, Huang, Mingxia, Dealwis, Chris Godfrey

“…Ribonucleotide reductases (RRs) catalyze the rate-limiting step of de novo deoxynucleotide (dNTP) synthesis. Eukaryotic RRs consist of two proteins, RR1 (α)…”
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Evaluating the therapeutic potential of a non-natural nucleotide that inhibits human ribonucleotide reductase by Ahmad, Md Faiz, Wan, Qun, Jha, Shalini, Motea, Edward, Berdis, Anthony, Dealwis, Chris

“…Human ribonucleotide reductase (hRR) is the key enzyme involved in de novo dNTP synthesis and thus represents an important therapeutic target against…”
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X-Ray Crystallography and Isothermal Titration Calorimetry Studies of the Salmonella Zinc Transporter ZntB by Wan, Qun, Ahmad, Md Faiz, Fairman, James, Gorzelle, Bonnie, de la Fuente, María, Dealwis, Chris, Maguire, Michael E.

“…The ZntB Zn2+ efflux system is important for maintenance of Zn2+ homeostasis in Enterobacteria. We report crystal structures of ZntB cytoplasmic domains from…”
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The Structural Basis for the Allosteric Regulation of Ribonucleotide Reductase by Ahmad, Md. Faiz, Dealwis, Chris G.

“…Ribonucleotide reductases (RRs) catalyze a crucial step of de novo DNA synthesis by converting ribonucleoside diphosphates to deoxyribonucleoside diphosphates…”
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X-ray structure of the ternary MTX·NADPH complex of the anthrax dihydrofolate reductase: A pharmacophore for dual-site inhibitor design by Bennett, Brad C., Wan, Qun, Ahmad, Md Faiz, Langan, Paul, Dealwis, Chris G.

“…For reasons of bioterrorism and drug resistance, it is imperative to identify and develop new molecular points of intervention against anthrax. Dihydrofolate…”
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The acid-induced state of glucose oxidase exists as a compact folded intermediate by Khatun Haq, Soghra, Faiz Ahmad, Md, Hasan Khan, Rizwan

“…A systematic investigation of the acid-induced unfolding of glucose oxidase (β- d-glucose: oxygen 1-oxidoreductase) (GOD) from Aspergillus niger was made using…”
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Treatment outcomes of childhood tuberculous meningitis: a systematic review and meta-analysis by Chiang, Silvia S, Dr, Khan, Faiz Ahmad, MD, Milstein, Meredith B, MPH, Tolman, Arielle W, BA, Benedetti, Andrea, PhD, Starke, Jeffrey R, Prof, Becerra, Mercedes C, ScD

“…Summary Background Tuberculous meningitis disproportionately affects young children. We aimed to characterise treatment outcomes for this deadliest and most…”
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Selective Cu2+ Binding, Redox Silencing, and Cytoprotective Effects of the Small Heat Shock Proteins αA- and αB-Crystallin by Ahmad, Md. Faiz, Singh, Devendra, Taiyab, Aftab, Ramakrishna, Tangirala, Raman, Bakthisaran, Rao, Ch. Mohan

“…Oxidative stress and Cu2+ have been implicated in several neurodegenerative diseases and in cataract. Oxidative stress, as well as Cu2+, is also known to…”
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Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule by Ahmad, Md. Faiz, Alam, Intekhab, Huff, Sarah E., Pink, John, Flanagan, Sheryl A., Shewach, Donna, Misko, Tessianna A., Oleinick, Nancy L., Harte, William E., Viswanathan, Rajesh, Harris, Michael E., Dealwis, Chris Godfrey

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