Search Results - "Ahmad, Ajmal"

Molecular mechanism of VEGF and its role in pathological angiogenesis by Ahmad, Ajmal, Nawaz, Mohd Imtiaz

“…Over the last seven decades, a significant scientific contribution took place in the delineation of the implications of vascular endothelial‐derived growth…”
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CD40 Ligand–CD40 Interaction Is an Intermediary between Inflammation and Angiogenesis in Proliferative Diabetic Retinopathy by Abu El-Asrar, Ahmed M, Nawaz, Mohd I, Ahmad, Ajmal, Dillemans, Luna, Siddiquei, Mairaj, Allegaert, Eef, Gikandi, Priscilla W, De Hertogh, Gert, Opdenakker, Ghislain, Struyf, Sofie

“…We aimed to investigate the role of the CD40-CD40 ligand (CD40L) pathway in inflammation-mediated angiogenesis in proliferative diabetic retinopathy (PDR). We…”
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AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission by Flippo, Kyle H, Gnanasekaran, Aswini, Perkins, Guy A, Ajmal, Ahmad, Merrill, Ronald A, Dickey, Audrey S, Taylor, Susan S, McKnight, G Stanley, Chauhan, Anil K, Usachev, Yuriy M, Strack, Stefan

“…Mitochondrial fission and fusion impact numerous cellular functions and neurons are particularly sensitive to perturbations in mitochondrial dynamics. Here we…”
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Differential Expression and Localization of ADAMTS Proteinases in Proliferative Diabetic Retinopathy by Abu El-Asrar, Ahmed M, Nawaz, Mohd Imtiaz, Allegaert, Eef, Siddiquei, Mohammad Mairaj, Ahmad, Ajmal, Gikandi, Priscilla, De Hertogh, Gert, Opdenakker, Ghislain

“…We analyzed the expression of ADAMTS proteinases ADAMTS-1, -2, -4, -5 and -13; their activating enzyme MMP-15; and the degradation products of proteoglycan…”
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Apocynin ameliorates NADPH oxidase 4 (NOX4) induced oxidative damage in the hypoxic human retinal Müller cells and diabetic rat retina by Ahmad, Ajmal, Nawaz, Mohd Imtiaz, Siddiquei, Mohammad Mairaj, Abu El-Asrar, Ahmed M.

“…NADPH oxidase (NOX) is a main producers of reactive oxygen species (ROS) that may contribute to the early pathogenesis of diabetic retinopathy (DR). ROS has…”
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Flavonoids and PI3K/Akt/mTOR Signaling Cascade: A Potential Crosstalk in Anticancer Treatment by Ul Islam, Badar, Suhail, Mohd, Khan, Mohd Shahnawaz, Ahmad, Ajmal, Zughaibi, Torki A, Husain, Fohad M, Rehman, Md Tabish, Tabrez, Shams

“…Cancer is one of the leading causes of death worldwide. A slight decline in mortality has been noted, but the currently available treatment options did not…”
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The Proinflammatory and Proangiogenic Macrophage Migration Inhibitory Factor Is a Potential Regulator in Proliferative Diabetic Retinopathy by Abu El-Asrar, Ahmed M, Ahmad, Ajmal, Siddiquei, Mohammad Mairaj, De Zutter, Alexandra, Allegaert, Eef, Gikandi, Priscilla W, De Hertogh, Gert, Van Damme, Jo, Opdenakker, Ghislain, Struyf, Sofie

“…The macrophage migration inhibitory factor (MIF)/CD74 signaling pathway is strongly implicated in inflammation and angiogenesis. We investigated the expression…”
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Anti-apoptotic and Anti-inflammatory effect of Piperine on 6-OHDA induced Parkinson's Rat model by Shrivastava, Pallavi, Vaibhav, Kumar, Tabassum, Rizwana, Khan, Andleeb, Ishrat, Tauheed, Khan, Mohd. Moshahid, Ahmad, Ajmal, Islam, Farah, Safhi, Mohammed M, Islam, Fakhrul

“…In the present study, we examined the molecular mechanism by which Piperine (bioactive compound of Piper nigrum) inhibits neuronal cell apoptosis. We further…”
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Genetic Ablation of Extra Domain A of Fibronectin in Hypercholesterolemic Mice Improves Stroke Outcome by Reducing Thrombo-Inflammation by Dhanesha, Nirav, Ahmad, Ajmal, Prakash, Prem, Doddapattar, Prakash, Lentz, Steven R, Chauhan, Anil K

“…The fibronectin-splicing variant containing extra domain A (Fn-EDA) is present in negligible amounts in the plasma of healthy humans but markedly elevated in…”
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Evaluation of Proteoforms of the Transmembrane Chemokines CXCL16 and CX3CL1, Their Receptors, and Their Processing Metalloproteinases ADAM10 and ADAM17 in Proliferative Diabetic Retinopathy by Abu El-Asrar, Ahmed M, Nawaz, Mohd Imtiaz, Ahmad, Ajmal, De Zutter, Alexandra, Siddiquei, Mohammad Mairaj, Blanter, Marfa, Allegaert, Eef, Gikandi, Priscilla W, De Hertogh, Gert, Van Damme, Jo, Opdenakker, Ghislain, Struyf, Sofie

“…The transmembrane chemokine pathways CXCL16/CXCR6 and CX3CL1/CX3CR1 are strongly implicated in inflammation and angiogenesis. We investigated the involvement…”
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Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT) by Ishrat, Tauheed, Hoda, Md Nasrul, Khan, M. Badruzzaman, Yousuf, Seema, Ahmad, Muzamil, Khan, Mohd. Moshahid, Ahmad, Ajmal, Islam, Fakhrul

“…Abstract Recent evidence indicates that curcumin (CUR), the principal curcuminoid of turmeric, exhibits antioxidant potential and protects the brain against…”
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Differential expression and localization of human tissue inhibitors of metalloproteinases in proliferative diabetic retinopathy by Abu El‐Asrar, Ahmed M., Ahmad, Ajmal, Bittoun, Emilie, Siddiquei, Mohammad Mairaj, Mohammad, Ghulam, Mousa, Ahmed, De Hertogh, Gert, Opdenakker, Ghislain

“…Purpose Tissue inhibitors of metalloproteinases (TIMPs) block the catalysis by matrix metalloproteinases (MMPs) and have additional biologic activities,…”
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Hesperidin ameliorates functional and histological outcome and reduces neuroinflammation in experimental stroke by Raza, Syed Shadab, Khan, Mohd. Moshahid, Ahmad, Ajmal, Ashafaq, Mohammad, Khuwaja, Gulrana, Tabassum, Rizwana, Javed, Hayate, Siddiqui, Mohammad Saeed, Safhi, Mohammed M, Islam, Fakhrul

“…Abstract Incidence of stroke is considered to be a major cause of death throughout the world. The middle cerebral artery occlusion (MCAO) for 2 h followed by…”
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Tissue Inhibitor of Metalloproteinase-3 Ameliorates Diabetes-Induced Retinal Inflammation by Abu El-Asrar, Ahmed M, Ahmad, Ajmal, Nawaz, Mohd Imtiaz, Siddiquei, Mohammad Mairaj, De Zutter, Alexandra, Vanbrabant, Lotte, Gikandi, Priscilla W, Opdenakker, Ghislain, Struyf, Sofie

“…Endogenous tissue inhibitor of matrix metalloproteinase-3 (TIMP-3) has powerful regulatory effects on inflammation and angiogenesis. In this study, we…”
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Galectin‐1 studies in proliferative diabetic retinopathy by Abu El‐Asrar, Ahmed M., Ahmad, Ajmal, Allegaert, Eef, Siddiquei, Mohammad Mairaj, Alam, Kaiser, Gikandi, Priscilla W., De Hertogh, Gert, Opdenakker, Ghislain

“…Purpose Galectin‐1 regulates endothelial cell function and promotes angiogenesis. We investigated the hypothesis that galectin‐1 may be involved in the…”
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Rutin Protects Dopaminergic Neurons from Oxidative Stress in an Animal Model of Parkinson’s Disease by Moshahid Khan, Mohd, Raza, Syed Shadab, Javed, Hayate, Ahmad, Ajmal, Khan, Andleeb, Islam, Farah, Safhi, Mohammed M., Islam, Fakhrul

“…This study was undertaken to investigate the neuroprotective effects of rutin (vitamin P) on 6-hydroxydopamine (6-OHDA)-induced Parkinson’s disease (PD) in…”
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Rutin protects the neural damage induced by transient focal ischemia in rats by Khan, Mohd. Moshahid, Ahmad, Ajmal, Ishrat, Tauheed, Khuwaja, Gulrana, Srivastawa, Pallavi, Khan, M. Badruzzaman, Raza, Syed Shadab, Javed, Hayate, Vaibhav, Kumar, Khan, Andleeb, Islam, Fakhrul

“…Abstract Free radical induced neural damage is implicated in cerebral ischemia–reperfusion (IR) injury and antioxidants are reported to have neuroprotective…”
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Proprotein convertase furin is a driver and potential therapeutic target in proliferative diabetic retinopathy by Abu El‐Asrar, Ahmed M., Nawaz, Mohd I., Ahmad, Ajmal, Siddiquei, Mohammad M., Allegaert, Eef, Gikandi, Priscilla W., De Hertogh, Gert, Opdenakker, Ghislain

“…Background Furin converts inactive proproteins into bioactive forms. By activating proinflammatory and proangiogenic factors, furin might play a role in…”
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Quercetin Protects Against Oxidative Stress Associated Damages in a Rat Model of Transient Focal Cerebral Ischemia and Reperfusion by Ahmad, Ajmal, Khan, Mohd. Moshahid, Hoda, Md. Nasrul, Raza, Syed Shadab, Khan, M. Badruzzaman, Javed, Hayate, Ishrat, Tauheed, Ashafaq, Mohammad, Ahmad, Md. Ejaz, Safhi, Mohammed M., Islam, Fakhrul

“…Experimental studies have demonstrated that oxidative stress and apoptosis play an important role in cerebral ischemic pathogenesis and may represent a target…”
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Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats: Behavioral, neurochemical and immunohistochemical studies by Khuwaja, Gulrana, Khan, Mohd. Moshahid, Ishrat, Tauheed, Ahmad, Ajmal, Raza, Syed Shadab, Ashafaq, Mohammad, Javed, Hayate, Khan, M. Badruzzaman, Khan, Andleeb, Vaibhav, Kumar, Safhi, Mohammed M, Islam, Fakhrul

“…Abstract Curcumin, the active principle of turmeric used in Indian curry is known for its antitumor, antioxidant, antiarthritic, anti-ischemic and…”
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