Search Results - "Ahluwalia, TS"
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The trans-ancestral genomic architecture of glycemic traits
Published in Nature genetics (01-06-2021)“…Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on…”
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A catalog of genetic loci associated with kidney function from analyses of a million individuals
Published in Nature genetics (01-06-2019)“…Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide…”
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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
Published in Nature genetics (01-02-2019)“…Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies…”
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Genome-wide association study identifies 74 loci associated with educational attainment
Published in Nature (London) (26-05-2016)“…A genome-wide association study in 293,723 individuals identifies 74 genetic variants associated with educational attainment, which, although only explaining a…”
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Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Published in Nature genetics (01-06-2016)“…Daniel Benjamin, Meike Bartels, Philipp Koellinger and colleagues report a genome-wide association meta-analysis of subjective well-being, depressive symptoms…”
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Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders
Published in American journal of human genetics (01-11-2018)“…C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The genetic determinants…”
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Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
Published in Nature genetics (2022)“…Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data…”
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Genome-wide analysis identifies 12 loci influencing human reproductive behavior
Published in Nature genetics (01-12-2016)“…Melinda Mills, Nicola Barban, Harold Snieder, Marcel den Hoed and colleagues perform a meta-analysis of data from over 300,000 individuals for age at first…”
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The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
Published in PLoS genetics (01-10-2015)“…Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio…”
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Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen
Published in Journal of the American Society of Nephrology (2019)“…Although diabetic kidney disease demonstrates both familial clustering and single nucleotide polymorphism heritability, the specific genetic factors…”
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A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes
Published in Diabetes (New York, N.Y.) (01-07-2018)“…Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the…”
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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Published in Nature communications (01-02-2016)“…To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association…”
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Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults
Published in PLoS genetics (27-04-2017)“…Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA,…”
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Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
Published in Nature communications (2017)“…Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when…”
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Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis
Published in Nature genetics (01-08-2018)“…Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized…”
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Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children
Published in The European respiratory journal (01-10-2022)“…Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking. Our…”
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European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation
Published in Nature communications (2023)“…Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the…”
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Directional dominance on stature and cognition in diverse human populations
Published in Nature (London) (23-07-2015)“…An analysis of 16 health-related quantitative traits in approximately 350,000 individuals reveals statistically significant associations between genome-wide…”
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Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies
Published in Kidney international (01-09-2022)“…Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or…”
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Genome-wide association study of circulating interleukin 6 levels identifies novel loci
Published in Human molecular genetics (2021)“…Abstract Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The…”
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