Search Results - "Ahlquist, David"

Universal cancer screening: revolutionary, rational, and realizable by Ahlquist, David A.

“…Cancer remains the second leading cause of mortality worldwide, and overall cancer-related deaths are increasing. Despite the survival benefit from early…”
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Molecular Detection of Colorectal Neoplasia by Ahlquist, David A

“…A variety of noninvasive molecular approaches to colorectal cancer screening are emerging with potential to improve screening effectiveness and…”
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Multi-Target Stool DNA Test: A New High Bar for Noninvasive Screening by Ahlquist, David A.

“…Stool DNA testing has evolved into what is now a highly accurate and well-validated test for the screen detection of colorectal neoplasia. An optimized and…”
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Multitarget Stool DNA Testing for Colorectal-Cancer Screening by Imperiale, Thomas F, Ransohoff, David F, Itzkowitz, Steven H, Levin, Theodore R, Lavin, Philip, Lidgard, Graham P, Ahlquist, David A, Berger, Barry M

“…A stool test that measures mutant KRAS, abnormal gene methylation, and hemoglobin detected significantly more colorectal cancers than a commercial fecal…”
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Magnitude of Missed Esophageal Adenocarcinoma After Barrett’s Esophagus Diagnosis: A Systematic Review and Meta-analysis by Visrodia, Kavel, Singh, Siddharth, Krishnamoorthi, Rajesh, Ahlquist, David A, Wang, Kenneth K, Iyer, Prasad G, Katzka, David A

“…Background & Aims A proportion of patients with Barrett’s esophagus (BE) are diagnosed with esophageal adenocarcinoma (EAC) within 1 year of an endoscopic…”
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Molecular markers for colorectal cancer screening by Dickinson, Brandon T, Kisiel, John, Ahlquist, David A, Grady, William M

“…Colorectal cancer (CRC), although a significant cause of morbidity and mortality worldwide, has seen a declining incidence and mortality in countries with…”
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Fecal Metabolomic Signatures in Colorectal Adenoma Patients Are Associated with Gut Microbiota and Early Events of Colorectal Cancer Pathogenesis by Kim, Minsuk, Vogtmann, Emily, Ahlquist, David A, Devens, Mary E, Kisiel, John B, Taylor, William R, White, Bryan A, Hale, Vanessa L, Sung, Jaeyun, Chia, Nicholas, Sinha, Rashmi, Chen, Jun

“…Colorectal adenomas are precancerous lesions of colorectal cancer (CRC) that offer a means of viewing the events key to early CRC development. A number of…”
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Hepatocellular Carcinoma Detection by Plasma Methylated DNA: Discovery, Phase I Pilot, and Phase II Clinical Validation by Kisiel, John B., Dukek, Brian A., V.S.R. Kanipakam, Reddappa, Ghoz, Hassan M., Yab, Tracy C., Berger, Calise K., Taylor, William R., Foote, Patrick H., Giama, Nasra H., Onyirioha, Kristeen, Abdallah, Mohamed A., Burger, Kelli N., Slettedahl, Seth W., Mahoney, Douglas W., Smyrk, Thomas C., Lewis, Jason T., Giakoumopoulos, Maria, Allawi, Hatim T., Lidgard, Graham P., Roberts, Lewis R., Ahlquist, David A.

“…Early detection improves hepatocellular carcinoma (HCC) outcomes, but better noninvasive surveillance tools are needed. We aimed to identify and validate…”
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Shifts in the Fecal Microbiota Associated with Adenomatous Polyps by Hale, Vanessa L, Chen, Jun, Johnson, Stephen, Harrington, Sean C, Yab, Tracy C, Smyrk, Thomas C, Nelson, Heidi, Boardman, Lisa A, Druliner, Brooke R, Levin, Theodore R, Rex, Douglas K, Ahnen, Dennis J, Lance, Peter, Ahlquist, David A, Chia, Nicholas

“…Adenomatous polyps are the most common precursor to colorectal cancer, the second leading cause of cancer-related death in the United States. We sought to…”
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Multitarget stool DNA test: clinical performance and impact on yield and quality of colonoscopy for colorectal cancer screening by Johnson, David H., MD, Kisiel, John B., MD, Burger, Kelli N., BS, Mahoney, Douglas W., MS, Devens, Mary E., CCRP, Ahlquist, David A., MD, Sweetser, Seth, MD

“…Background and Aims Multitarget stool DNA (MT-sDNA) testing is now approved by the U.S. Food and Drug Administration for average-risk colorectal cancer…”
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New DNA Methylation Markers for Pancreatic Cancer: Discovery, Tissue Validation, and Pilot Testing in Pancreatic Juice by Kisiel, John B, Raimondo, Massimo, Taylor, William R, Yab, Tracy C, Mahoney, Douglas W, Sun, Zhifu, Middha, Sumit, Baheti, Saurabh, Zou, Hongzhi, Smyrk, Thomas C, Boardman, Lisa A, Petersen, Gloria M, Ahlquist, David A

“…Discriminant markers for pancreatic cancer detection are needed. We sought to identify and validate methylated DNA markers for pancreatic cancer using…”
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Endoscopic overestimation of colorectal polyp size by Anderson, Bradley W., MD, Smyrk, Thomas C., MD, Anderson, Kari S, Mahoney, Douglas W., MS, Devens, Mary E., BA, Sweetser, Seth R., MD, Kisiel, John B., MD, Ahlquist, David A., MD

“…Background and Aims Polyp size ≥1 cm triggers more frequent colonoscopic surveillance, yet size is typically based on subjective endoscopic estimates. We…”
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Next-Generation Stool DNA Test Accurately Detects Colorectal Cancer and Large Adenomas by Ahlquist, David A, Zou, Hongzhi, Domanico, Michael, Mahoney, Douglas W, Yab, Tracy C, Taylor, William R, Butz, Malinda L, Thibodeau, Stephen N, Rabeneck, Linda, Paszat, Lawrence F, Kinzler, Kenneth W, Vogelstein, Bert, Bjerregaard, Niels Chr, Laurberg, Søren, Sørensen, Henrik Toft, Berger, Barry M, Lidgard, Graham P

“…Background & Aims Technical advances have led to stool DNA (sDNA) tests that might accurately detect neoplasms on both sides of the colorectum. We assessed…”
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Nanopore-Based Assay for Detection of Methylation in Double-Stranded DNA Fragments by Shim, Jiwook, Kim, Younghoon, Humphreys, Gwendolyn I, Nardulli, Ann M, Kosari, Farhad, Vasmatzis, George, Taylor, William R, Ahlquist, David A, Myong, Sua, Bashir, Rashid

“…DNA methylation is an epigenetic modification of DNA in which methyl groups are added at the 5-carbon position of cytosine. Aberrant DNA methylation, which has…”
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Highly Discriminant Methylated DNA Markers for the Non-endoscopic Detection of Barrett's Esophagus by Iyer, Prasad G, Taylor, William R, Johnson, Michele L, Lansing, Ramona L, Maixner, Kristyn A, Yab, Tracy C, Simonson, Julie A, Devens, Mary E, Slettedahl, Seth W, Mahoney, Douglas W, Berger, Calise K, Foote, Patrick H, Smyrk, Thomas C, Wang, Kenneth K, Wolfsen, Herbert C, Ahlquist, David A

“…Minimally invasive methods have been described to detect Barrett's esophagus (BE), but are limited by subjectivity and suboptimal accuracy. We identified…”
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Stool-Based Tests Vs Screening Colonoscopy for the Detection of Colorectal Cancer by Ahlquist, David A

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Stool DNA Testing for Screening Detection of Colorectal Neoplasia in Alaska Native People by Redwood, Diana G., PhD, Asay, Elvin D., MS, Blake, Ian D., MS, Sacco, Pamela E., RN, Christensen, Claudia M., ANP, Sacco, Frank D., MD, Tiesinga, James J., MD, Devens, Mary E., BA, Alberts, Steven R., MD, Mahoney, Douglas W., MS, Yab, Tracy C., BS, Foote, Patrick H., MD, Smyrk, Thomas C., MD, Provost, Ellen M., DO, Ahlquist, David A., MD

“…Abstract Objective To assess the accuracy of a multitarget stool DNA test (MT-sDNA) compared with fecal immunochemical testing for hemoglobin (FIT) for…”
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Cost-Effectiveness of Multitarget Stool DNA Testing vs Colonoscopy or Fecal Immunochemical Testing for Colorectal Cancer Screening in Alaska Native People by Redwood, Diana G., Dinh, Tuan A., Kisiel, John B., Borah, Bijan J., Moriarty, James P., Provost, Ellen M., Sacco, Frank D., Tiesinga, James J., Ahlquist, David A.

“…To estimate the cost-effectiveness of multitarget stool DNA testing (MT-sDNA) compared with colonoscopy and fecal immunochemical testing (FIT) for Alaska…”
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Early detection of sporadic pancreatic cancer: summative review by Chari, Suresh T, Kelly, Kimberly, Hollingsworth, Michael A, Thayer, Sarah P, Ahlquist, David A, Andersen, Dana K, Batra, Surinder K, Brentnall, Teresa A, Canto, Marcia, Cleeter, Deborah F, Firpo, Matthew A, Gambhir, Sanjiv Sam, Go, Vay Liang W, Hines, O Joe, Kenner, Barbara J, Klimstra, David S, Lerch, Markus M, Levy, Michael J, Maitra, Anirban, Mulvihill, Sean J, Petersen, Gloria M, Rhim, Andrew D, Simeone, Diane M, Srivastava, Sudhir, Tanaka, Masao, Vinik, Aaron I, Wong, David

“…Pancreatic cancer (PC) is estimated to become the second leading cause of cancer death in the United States by 2020. Early detection is the key to improving…”
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Detection of colorectal serrated polyps by stool DNA testing: comparison with fecal immunochemical testing for occult blood (FIT) by Heigh, Russell I, Yab, Tracy C, Taylor, William R, Hussain, Fareeda T N, Smyrk, Thomas C, Mahoney, Douglas W, Domanico, Michael J, Berger, Barry M, Lidgard, Graham P, Ahlquist, David A

“…Precursors to 1/3 of colorectal cancer (CRC), serrated polyps have been under-detected by screening due to their inconspicuous, non-hemorrhagic, and proximal…”
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