Search Results - "Ahlijanian, M"

A Phase 1 Single-Ascending-Dose Trial in Healthy Volunteers to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Intravenous PNT001, a Novel Mid-domain Tau Antibody Targeting cis-pT231 Tau by Luca, Wendy, Foster, K., McClure, K., Ahlijanian, M. K., Jefson, M.

“…Background PNT001 is a humanized full-length IgG4 S228P monoclonal antibody that binds the cis conformation of the phosphorylated Thr231-Pro232 motif in human…”
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BMS-986089: A novel adnectin protein that dose dependently lowers free myostatin and increases muscle volume and lean body mass by Jacobsen, L, Bechtold, C, Tirucherai, G, Ahlijanian, M, Luo, F

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Phenotypic differences in mdx mice on C57Bl/10 and DBA/2 backgrounds by Keenan, S, Snyder, B, Xiao, H, Robertson, A, Ahlijanian, M, Bristow, L, Devidze, N

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BMS-986089 is a high affinity anti-myostatin adnectin that increases muscle volume in three preclinical species by Madireddi, M, Malone, H, Kukral, D, Chimalakonda, A, Kozhich, A, Xiling, Y, Swain, J, Yamniuk, A, Ahlijanian, M

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Divergent CSF   alterations in two common tauopathies: Alzheimer's disease and progressive supranuclear palsy by Wagshal, D., Sankaranarayanan, S., Guss, V., Hall, T., Berisha, F., Lobach, I., Karydas, A., Voltarelli, L., Scherling, C., Heuer, H., Tartaglia, M. C., Miller, Z., Coppola, G., Ahlijanian, M., Soares, H., Kramer, J. H., Rabinovici, G. D., Rosen, H. J., Miller, B. L., Meredith, J., Boxer, A. L.

“…Background Elevated CSF Ï,, is considered a biomarker of neuronal injury in newly developed Alzheimer's disease (AD) and mild cognitive impairment (MCI)…”
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Identification and differential subcellular localization of the neuronal class C and class D L-type calcium channel alpha 1 subunits by Hell, J W, Westenbroek, R E, Warner, C, Ahlijanian, M K, Prystay, W, Gilbert, M M, Snutch, T P, Catterall, W A

“…To identify and localize the protein products of genes encoding distinct L-type calcium channels in central neurons, anti-peptide antibodies specific for the…”
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Molecular Cloning of the α-1 Subunit of an ω-Conotoxin-Sensitive Calcium Channel by Dubel, Stefan J., Terry V. B. Starr, Hell, Johannes, Ahlijanian, Michael K., Enyeart, John J., Catterall, William A., Snutch, Terry P.

“…Of the four major types of Ca channel described in vertebrate cells (designated T, L, N, and P), N-type Ca channels are unique in that they are found…”
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Partial Rescue of the p35-/- Brain Phenotype by Low Expression of a Neuronal-Specific Enolase p25 Transgene by Patzke, Holger, Maddineni, Upendra, Ayala, Ramses, Morabito, Maria, Volker, Janet, Dikkes, Pieter, Ahlijanian, Michael K, Tsai, Li-Huei

“…Cyclin-dependent kinase 5 (Cdk5) is activated on binding of activator proteins p35 and p39. A N-terminally truncated p35, termed p25, is generated through…”
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L-type calcium channels in insulin-secreting cells: biochemical characterization and phosphorylation in RINm5F cells by Safayhi, H, Haase, H, Kramer, U, Bihlmayer, A, Roenfeldt, M, Ammon, H P, Froschmayr, M, Cassidy, T N, Morano, I, Ahlijanian, M K, Striessnig, J

“…Opening of dihydropyridine-sensitive voltage-dependent L-type Ca2+-channels (LTCCs) represents the final common pathway for insulin secretion in pancreatic…”
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P.15 - BMS-986089: A novel adnectin protein that dose dependently lowers free myostatin and increases muscle volume and lean body mass by Jacobsen, L., Bechtold, C., Tirucherai, G., Ahlijanian, M., Luo, F.

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Subunit structure and localization of dihydropyridine-sensitive calcium channels in mammalian brain, spinal cord, and retina by Ahlijanian, M K, Westenbroek, R E, Catterall, W A

“…Monoclonal antibodies that recognize the alpha 2 delta subunits of calcium channels from skeletal muscle immunoprecipitate a complex of alpha 1, alpha 2 delta,…”
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Phosphorylation of an alpha 1-like subunit of an omega -conotoxin-sensitive brain calcium channel by cAMP-dependent protein kinase and protein kinase C by Ahlijanian, M K, Striessnig, J, Catterall, WA

“…Antibodies that recognize the alpha 2 delta and alpha 1 subunits of skeletal muscle L-type calcium channels have been used to investigate the subunit…”
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Dopamine, acting through D-2 receptors, inhibits rat striatal adenylate cyclase by a GTP-dependent process by Cooper, D M, Bier-Laning, C M, Halford, M K, Ahlijanian, M K, Zahniser, N R

“…This report demonstrates that the D-2 dopamine receptors that are present in rat striatum can directly inhibit the activity of adenylate cyclase in a…”
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Antagonism of calmodulin-stimulated adenylate cyclase by trifluoperazine, calmidazolium and W-7 in rat cerebellar membranes by Ahlijanian, M K, Cooper, D M

“…Ca++-calmodulin (CaM)-dependent stimulation of adenylate cyclase in rat cerebellar plasma membranes was demonstrated by removal of endogenous Ca++ and CaM and…”
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G.P.361 - Phenotypic differences in mdx mice on C57Bl/10 and DBA/2 backgrounds by Keenan, S., Snyder, B., Xiao, H., Robertson, A., Ahlijanian, M., Bristow, L., Devidze, N.

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P.14 - BMS-986089 is a high affinity anti-myostatin adnectin that increases muscle volume in three preclinical species by Madireddi, M., Malone, H., Kukral, D., Chimalakonda, A., Kozhich, A., Xiling, Y., Swain, J., Yamniuk, A., Ahlijanian, M.

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Effects of (-)-N6-(R-phenylisopropyl)-adenosine (PIA) and caffeine on nociception and morphine-induced analgesia, tolerance and dependence in mice by Ahlijanian, M K, Takemori, A E

“…(-)-N6-(R-phenylisopropyl)-adenosine (PIA) was shown to possess analgesic activity in both the tail flick and acetic acid writhing assays. The analgesic…”
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Cdk5 Is a Key Factor in Tau Aggregation and Tangle Formation In Vivo by Noble, Wendy, Olm, Vicki, Takata, Kazuyuki, Casey, Evelyn, Mary, O, Meyerson, Jordana, Gaynor, Kate, LaFrancois, John, Wang, Lili, Kondo, Takayuki, Davies, Peter, Burns, Mark, Veeranna, Nixon, Ralph, Dickson, Dennis, Matsuoka, Yasuji, Ahlijanian, Michael, Lau, Lit-Fui, Duff, Karen

“…Tau aggregation is a common feature of neurodegenerative diseases such as Alzheimer's disease, and hyperphosphorylation of tau has been implicated as a…”
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Changes in adenosine receptor sensitivity in morphine-tolerant and -dependent mice by Ahlijanian, M K, Takemori, A E

“…Treatment of mice with either a 75-mg morphine pellet (72 h) s.c. or 100 mg/kg of morphine s.c. (3.5 h) did not alter the ED50 of…”
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Calmodulin may play a pivotal role in neurotransmitter-mediated inhibition and stimulation of rat cerebellar adenylate cyclase by Ahlijanian, M K, Cooper, D M

“…Adenylate cyclase activity was stimulated 2.5-fold by exogenous Ca2+/calmodulin (CaM) (1 microM) in rat cerebellar plasma membranes which had been depleted of…”
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