Search Results - "Aherrahrou, Zouhair"

ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1 by Kessler, Thorsten, Zhang, Lu, Liu, Ziyi, Yin, Xiaoke, Huang, Yaqian, Wang, Yingbao, Fu, Yi, Mayr, Manuel, Ge, Qing, Xu, Qingbo, Zhu, Yi, Wang, Xian, Schmidt, Kjestine, de Wit, Cor, Erdmann, Jeanette, Schunkert, Heribert, Aherrahrou, Zouhair, Kong, Wei

“…ADAMTS-7, a member of the disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family, was recently identified to be significantly associated…”
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Identification of a functional missense variant in the matrix metallopeptidase 10 (MMP10) gene in two families with premature myocardial infarction by Verovenko, Viktor, Tennstedt, Stephanie, Kleinecke, Mariana, Kessler, Thorsten, Schunkert, Heribert, Erdmann, Jeanette, Ensminger, Stephan, Aherrahrou, Zouhair

“…A positive family history is a major independent risk factor for atherosclerosis, and genetic variation is an important aspect of cardiovascular disease…”
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CYP17A1 deficient XY mice display susceptibility to atherosclerosis, altered lipidomic profile and atypical sex development by Aherrahrou, Redouane, Kulle, Alexandra E., Alenina, Natalia, Werner, Ralf, Vens-Cappell, Simeon, Bader, Michael, Schunkert, Heribert, Erdmann, Jeanette, Aherrahrou, Zouhair

“…CYP17A1 is a cytochrome P450 enzyme with 17-alpha-hydroxylase and C17,20-lyase activities. CYP17A1 genetic variants are associated with coronary artery…”
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Mitochondrial DNA variants and microbiota: An experimental strategy to identify novel therapeutic potential in chronic inflammatory diseases by Olbrich, Michael, Hartmann, Adina-Malin, Künzel, Sven, Aherrahrou, Zouhair, Schilf, Paul, Baines, John F., Ibrahim, Saleh M., Hirose, Misa

“…We previously demonstrated that mice carrying natural mtDNA variants of the FVB/NJ strain (m.7778 G>T in the mt-Atp8 gene in mitochondrial complex V), namely…”
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Compartment-resolved Proteomic Analysis of Mouse Aorta during Atherosclerotic Plaque Formation Reveals Osteoclast-specific Protein Expression by Wierer, Michael, Prestel, Matthias, Schiller, Herbert B., Yan, Guangyao, Schaab, Christoph, Azghandi, Sepiede, Werner, Julia, Kessler, Thorsten, Malik, Rainer, Murgia, Marta, Aherrahrou, Zouhair, Schunkert, Heribert, Dichgans, Martin, Mann, Matthias

“…Atherosclerosis leads to vascular lesions that involve major rearrangements of the vascular proteome, especially of the extracellular matrix (ECM). Using…”
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Induced Pluripotent Stem Cells (iPSCs) in Vascular Research: from Two- to Three-Dimensional Organoids by Trillhaase, Anja, Maertens, Marlon, Aherrahrou, Zouhair, Erdmann, Jeanette

“…Stem cell technology has been around for almost 30 years and in that time has grown into an enormous field. The stem cell technique progressed from the first…”
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Beyond the Basics: Unraveling the Complexity of Coronary Artery Calcification by Hashmi, Satwat, Shah, Pashmina Wiqar, Aherrahrou, Zouhair, Aikawa, Elena, Aherrahrou, Rédouane

“…Coronary artery calcification (CAC) is mainly associated with coronary atherosclerosis, which is an indicator of coronary artery disease (CAD). CAC refers to…”
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The CAD risk locus 9p21 increases the risk of vascular calcification in an iPSC-derived VSMC model by Trillhaase, Anja, Schmidt, Beatrice, Märtens, Marlon, Haferkamp, Undine, Erdmann, Jeanette, Aherrahrou, Zouhair

“…Coronary artery disease (CAD) is the leading cause of death worldwide. Chromosome locus 9p21 was the first to be associated with increased risk of CAD and…”
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In silico candidate variant and gene identification using inbred mouse strains by Munz, Matthias, Khodaygani, Mohammad, Aherrahrou, Zouhair, Busch, Hauke, Wohlers, Inken

“…Mice are the most widely used animal model to study genotype to phenotype relationships. Inbred mice are genetically identical, which eliminates genetic…”
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Dare to Compare. Development of Atherosclerotic Lesions in Human, Mouse, and Zebrafish by Vedder, Viviana L., Aherrahrou, Zouhair, Erdmann, Jeanette

“…Cardiovascular diseases, such as atherosclerosis, are the leading cause of death worldwide. Although mice are currently the most commonly used model for…”
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A familial congenital heart disease with a possible multigenic origin involving a mutation in BMPR1A by Demal, Till Joscha, Heise, Melina, Reiz, Benedikt, Dogra, Deepika, Brænne, Ingrid, Reichenspurner, Hermann, Männer, Jörg, Aherrahrou, Zouhair, Schunkert, Heribert, Erdmann, Jeanette, Abdelilah-Seyfried, Salim

“…The genetics of many congenital heart diseases (CHDs) can only unsatisfactorily be explained by known chromosomal or Mendelian syndromes. Here, we present…”
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sGC Activity and Regulation of Blood Flow in a Zebrafish Model System by Vishnolia, Krishan K, Rakovic, Aleksandar, Hoene, Celine, Tarhbalouti, Karim, Aherrahrou, Zouhair, Erdmann, Jeanette

“…Soluble guanylyl cyclase (sGC) protein is a heterodimer formed by two subunits encoded by and genes. The chromosomal locus 4q32.1 harbors both of these genes,…”
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miR-128a Acts as a Regulator in Cardiac Development by Modulating Differentiation of Cardiac Progenitor Cell Populations by Hoelscher, Sarah C, Stich, Theresia, Diehm, Anne, Lahm, Harald, Dreßen, Martina, Zhang, Zhong, Neb, Irina, Aherrahrou, Zouhair, Erdmann, Jeanette, Schunkert, Heribert, Santamaria, Gianluca, Cuda, Giovanni, Gilsbach, Ralf, Hein, Lutz, Lange, Rüdiger, Hassel, David, Krane, Markus, Doppler, Stefanie A

“…MicroRNAs (miRs) appear to be major, yet poorly understood players in regulatory networks guiding cardiogenesis. We sought to identify miRs with unknown…”
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Incidence of microvascular dysfunction is increased in hyperlipidemic mice, reducing cerebral blood flow and impairing remote memory by Hernandez Torres, Luis Daniel, Rezende, Flavia, Peschke, Eva, Will, Olga, Hövener, Jan-Bernd, Spiecker, Frauke, Özorhan, Ümit, Lampe, Josephine, Stölting, Ines, Aherrahrou, Zouhair, Künne, Carsten, Kusche-Vihrog, Kristina, Matschl, Urte, Hille, Susanne, Brandes, Ralf P, Schwaninger, Markus, Müller, Oliver J, Raasch, Walter

“…The development of cognitive dysfunction is not necessarily associated with diet-induced obesity. We hypothesized that cognitive dysfunction might require…”
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Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease by Linsel-Nitschke, Patrick, Heeren, Jörg, Aherrahrou, Zouhair, Bruse, Petra, Gieger, Christian, Illig, Thomas, Prokisch, Holger, Heim, Katharina, Doering, Angela, Peters, Annette, Meitinger, Thomas, Wichmann, H.-Erich, Hinney, Anke, Reinehr, Thomas, Roth, Christian, Ortlepp, Jan. R, Soufi, Mouhidien, Sattler, Alexander M, Schaefer, Jürgen, Stark, Klaus, Hengstenberg, Christian, Schaefer, Arne, Schreiber, Stefan, Kronenberg, Florian, Samani, Nilesh J, Schunkert, Heribert, Erdmann, Jeanette

“…Abstract Background A single nucleotide polymorphism (SNP) rs599839 located at chromosome 1p13.3 has previously been associated with risk of coronary artery…”
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Retraction notice to “Differentiation of human iPSCs into VSMCs and generation of VSMC-derived calcifying vascular cells” [Stem Cell Res. 31 (2018) 62–70] by Trillhaase, Anja, Haferkamp, Undine, Rangnau, Alexandra, Märtens, Marlon, Schmidt, Beatrice, Trilck, Michaela, Seibler, Philip, Aherrahrou, Redouane, Erdmann, Jeanette, Aherrahrou, Zouhair

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pyHeart4Fish : Chamber-specific heart phenotype quantification of zebrafish in high-content screens by Vedder, Viviana L, Reinberger, Tobias, Haider, Syed M I, Eichelmann, Luis, Odenthal, Nadine, Abdelilah-Seyfried, Salim, Aherrahrou, Zouhair, Breuer, Maximilian, Erdmann, Jeanette

“…Cardiovascular diseases (CVDs) are the leading cause of death. Of CVDs, congenital heart diseases are the most common congenital defects, with a prevalence of…”
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Studies in Zebrafish Demonstrate That CNNM2 and NT5C2 Are Most Likely the Causal Genes at the Blood Pressure-Associated Locus on Human Chromosome 10q24.32 by Vishnolia, Krishan K., Hoene, Celine, Tarhbalouti, Karim, Revenstorff, Julian, Aherrahrou, Zouhair, Erdmann, Jeanette

“…Background: Globally, high blood pressure (BP) is the most important risk factor for cardiovascular disease. Several genome-wide association studies (GWAS)…”
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Effect of Differences in the Microbiome of Cyp17a1 -Deficient Mice on Atherosclerotic Background by Künstner, Axel, Aherrahrou, Redouane, Hirose, Misa, Bruse, Petra, Ibrahim, Saleh Mohamed, Busch, Hauke, Erdmann, Jeanette, Aherrahrou, Zouhair

“…CYP17A1 is a cytochrome P450 enzyme that has 17-alpha-hydroxylase and C17,20-lyase activities. deficiency is associated with high body mass and visceral fat…”
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The Level of Hepatic ABCC6 Expression Determines the Severity of Calcification after Cardiac Injury by Brampton, Christopher, Aherrahrou, Zouhair, Chen, Li-Hsieh, Martin, Ludovic, Bergen, Arthur A.B, Gorgels, Theo G.M.F, Erdfdi, Jeannette, Schunkert, Heribert, Szabó, Zalán, Váradi, András, Le Saux, Olivier

“…Because vascular or cardiac mineralization is inversely correlated with morbidity and long-term survival, we investigated the role of ABCC6 in the…”
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