Search Results - "Aherne, Sinead T"

Correlating transcriptional networks to breast cancer survival: a large-scale coexpression analysis by Clarke, Colin, Madden, Stephen F, Doolan, Padraig, Aherne, Sinead T, Joyce, Helena, O'Driscoll, Lorraine, Gallagher, William M, Hennessy, Bryan T, Moriarty, Michael, Crown, John, Kennedy, Susan, Clynes, Martin

“…Weighted gene coexpression network analysis (WGCNA) is a powerful 'guilt-by-association'-based method to extract coexpressed groups of genes from large…”
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Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression by Aherne, Sinéad T, Madden, Stephen F, Hughes, David J, Pardini, Barbara, Naccarati, Alessio, Levy, Miroslav, Vodicka, Pavel, Neary, Paul, Dowling, Paul, Clynes, Martin

“…Screening for the early detection of colorectal cancer is important to improve patient survival. The aim of this study was to investigate the potential of…”
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BreastMark: an integrated approach to mining publicly available transcriptomic datasets relating to breast cancer outcome by Madden, Stephen F, Clarke, Colin, Gaule, Patricia, Aherne, Sinead T, O'Donovan, Norma, Clynes, Martin, Crown, John, Gallagher, William M

“…Breast cancer is a complex heterogeneous disease for which a substantial resource of transcriptomic data is available. Gene expression data have facilitated…”
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Manipulating MiRNA Expression to Uncover Hidden Functions by Aherne, Sinéad T, Lao, Nga T

“…There are a numerous target prediction algorithms that allow users to identify putative targets of their microRNAs (miRNAs) of interest. Although these tools…”
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Altered expression of mir-222 and mir-25 influences diverse gene expression changes in transformed normal and anaplastic thyroid cells, and impacts on MEK and TRAIL protein expression by Aherne, Sinéad T, Smyth, Paul, Freeley, Michael, Smith, Leila, Spillane, Cathy, O'leary, John, Sheils, Orla

“…Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer-related deaths each year. Our group and others have…”
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A gene expression profile indicative of early stage HER2 targeted therapy response by O'Neill, Fiona, Madden, Stephen F, Clynes, Martin, Crown, John, Doolan, Padraig, Aherne, Sinéad T, O'Connor, Robert

“…Efficacious application of HER2-targetting agents requires the identification of novel predictive biomarkers. Lapatinib, afatinib and neratinib are tyrosine…”
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Comparative transcriptomic analysis of cultivated limbal epithelium and donor corneal tissue reveals altered wound healing gene expression by Gallagher, Clair, Clarke, Colin, Aherne, Sinéad T, Katikireddy, Kishore R, Doolan, Padraig, Lynch, Vincent, Shaw, Sandra, Bobart-Hone, Andra, Murphy, Conor, Clynes, Martin, Power, William, O'Sullivan, Finbarr

“…The improved surgical outcomes associated with transplantation of cultivated amniotic membrane expanded limbal epithelium (AMLE) compared to traditional donor…”
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Potentially important microRNA cluster on chromosome 17p13.1 in primary peritoneal carcinoma by Flavin, Richard J, Smyth, Paul C, Laios, Alexandros, O'Toole, Sharon A, Barrett, Ciara, Finn, Stephen P, Russell, Susan, Ring, Martina, Denning, Karen M, Li, Jinghuan, Aherne, Sinead T, Sammarae, Dania A, Aziz, Natasha A, Alhadi, Araibi, Sheppard, Brian L, Lao, Kai, Sheils, Orla M, O'Leary, John J

“…MicroRNAs are a group of small non-coding RNAs approximately 22 nucleotides in length. Recent work has shown differential expression of mature microRNAs in…”
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Gene expression changes as markers of early lapatinib response in a panel of breast cancer cell lines by O'Neill, Fiona, Madden, Stephen F, Aherne, Sinead T, Clynes, Martin, Crown, John, Doolan, Padraig, O'Connor, Robert

“…Lapatinib, a tyrosine kinase inhibitor of HER2 and EGFR and is approved, in combination with capecitabine, for the treatment of trastuzumab-refractory…”
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Geographical mapping of a multifocal thyroid tumour using genetic alteration analysis & miRNA profiling by Aherne, Sinéad T, Smyth, Paul C, Flavin, Richard J, Russell, Susan M, Denning, Karen M, Li, Jing Huan, Guenther, Simone M, O'Leary, John J, Sheils, Orla M

“…Papillary thyroid carcinoma (PTC) frequently presents as multiple tumour-foci within a single thyroid gland or pluriform, with synchronous tumours comprising…”
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Regulation of microRNA biosynthesis and expression in 2102Ep embryonal carcinoma stem cells is mirrored in ovarian serous adenocarcinoma patients by Gallagher, Michael F, Flavin, Richard J, Elbaruni, Salah A, McInerney, Jamie K, Smyth, Paul C, Salley, Yvonne M, Vencken, Sebastian F, O'Toole, Sharon A, Laios, Alexandros, Lee, Mathia Yc, Denning, Karen, Li, Jinghuan, Aherne, Sinead T, Lao, Kai Q, Martin, Cara M, Sheils, Orla M, O'Leary, John J

“…Tumours with high proportions of differentiated cells are considered to be of a lower grade to those containing high proportions of undifferentiated cells…”
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Transcriptomic analysis of clonal growth rate variation during CHO cell line development by Doolan, Padraig, Clarke, Colin, Kinsella, Paula, Breen, Laura, Meleady, Paula, Leonard, Mark, Zhang, Lin, Clynes, Martin, Aherne, Sinead T., Barron, Niall

“…•Global transcriptomic analysis of a single CHO cell line development project.•Ten CHO K1 sister clones with similar cell specific productivity varying in…”
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Altered eIF6 and Dicer expression is associated with clinicopathological features in ovarian serous carcinoma patients by Flavin, Richard J, Smyth, Paul C, Finn, Stephen P, Laios, Alexandros, O'Toole, Sharon A, Barrett, Ciara, Ring, Martina, Denning, Karen M, Li, Jinghuan, Aherne, Sinead T, Aziz, Natasha A, Alhadi, Araibi, Sheppard, Brian L, Loda, Massimo, Martin, Cara, Sheils, Orla M, O'Leary, John J

“…MicroRNAs are a group of small non-coding RNAs approximately 22 nucleotides in length. Recent work has shown differential expression of mature microRNAs in…”
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A molecular expression signature distinguishing follicular lesions in thyroid carcinoma using preamplification RT-PCR in archival samples by Denning, Karen M, Smyth, Paul C, Cahill, Susanne F, Finn, Stephen P, Conlon, Eilish, Li, JingHuan, Flavin, Richard J, Aherne, Sinead T, Guenther, Simone M, Ferlinz, Astrid, O'Leary, John J, Sheils, Orla M

“…Follicular variant of papillary thyroid carcinoma is a lesion that frequently causes difficulties from a diagnostic perspective in the laboratory. The purpose…”
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Abstract 1091: miR-125 family of miRNAs mediates prostate cancer cell proliferation and migration by Aherne, Sinead T., O’Neill, Fiona, Madden, Stephen F., Clynes, Martin, Lynch, Conor C.

“…Abstract Background: Prostate cancer is the second most common malignancy in American men and causes ∼27540 deaths per annum. microRNAs (miRNAs) are a class of…”
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