Search Results - "Ahearn, Ian M."

Regulating the regulator: post-translational modification of RAS by Ahearn, Ian M., Haigis, Kevin, Bar-Sagi, Dafna, Philips, Mark R.

“…Key Points RAS proteins are molecular switches that regulate a wide range of signalling pathways by engaging effectors on cellular membranes. They are…”
Get full text

FKBP12 Binds to Acylated H-Ras and Promotes Depalmitoylation by Ahearn, Ian M., Tsai, Frederick D., Court, Helen, Zhou, Mo, Jennings, Benjamin C., Ahmed, Mahiuddin, Fehrenbacher, Nicole, Linder, Maurine E., Philips, Mark R.

“…A cycle of palmitoylation/depalmitoylation of H-Ras mediates bidirectional trafficking between the Golgi apparatus and the plasma membrane, but nothing is…”
Get full text

A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells by Chen, Xue, Yao, Haidong, Kashif, Muhammad, Revêchon, Gwladys, Eriksson, Maria, Hu, Jianjiang, Wang, Ting, Liu, Yiran, Tüksammel, Elin, Strömblad, Staffan, Ahearn, Ian M, Philips, Mark R, Wiel, Clotilde, Ibrahim, Mohamed X, Bergo, Martin O

“…A farnesylated and methylated form of prelamin A called progerin causes Hutchinson-Gilford progeria syndrome (HGPS). Inhibiting progerin methylation by…”
Get full text

Enhancing adherence for total body skin examination in post-surgical veterans: an interventional study at an urban Veterans Affairs center by Ramachandran, Vignesh, Kakpovbia, Efe, Juarez, Michelle C, Jairath, Neil, Nemcevic, Andjela, Akoh, Christine C, Ahearn, Ian M, Tattersall, Ian W, Lee, Nayoung, Latkowski, Jo-Ann M, Zampella, John G

Get full text

Phospholipase D1 Regulates Lymphocyte Adhesion via Upregulation of Rap1 at the Plasma Membrane by Mor, Adam, Wynne, Joseph P., Ahearn, Ian M., Dustin, Michael L., Du, Guangwei, Philips, Mark R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

The structural features that distinguish PD-L2 from PD-L1 emerged in placental mammals by Philips, Elliot A., Garcia-España, Antonio, Tocheva, Anna S., Ahearn, Ian M., Adam, Kieran R., Pan, Ruimin, Mor, Adam, Kong, Xiang-Peng

“…Programmed cell death protein 1 (PD-1) is an inhibitory receptor on T lymphocytes that is critical for modulating adaptive immunity. As such, it has been…”
Get full text

KRAS4A directly regulates hexokinase 1 by Amendola, Caroline R., Mahaffey, James P., Parker, Seth J., Ahearn, Ian M., Chen, Wei-Ching, Zhou, Mo, Court, Helen, Shi, Jie, Mendoza, Sebastian L., Morten, Michael J., Rothenberg, Eli, Gottlieb, Eyal, Wadghiri, Youssef Z., Possemato, Richard, Hubbard, Stevan R., Balmain, Allan, Kimmelman, Alec C., Philips, Mark R.

“…The most frequently mutated oncogene in cancer is KRAS , which uses alternative fourth exons to generate two gene products (KRAS4A and KRAS4B) that differ only…”
Get full text

Topology of Mammalian Isoprenylcysteine Carboxyl Methyltransferase Determined in Live Cells with a Fluorescent Probe by Wright, Latasha P., Court, Helen, Mor, Adam, Ahearn, Ian M., Casey, Patrick J., Philips, Mark R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association by Zhou, Mo, Kuruvilla, Leena, Shi, Xiarong, Viviano, Stephen, Ahearn, Ian M., Amendola, Caroline R., Su, Wenjuan, Badri, Sana, Mahaffey, James, Fehrenbacher, Nicole, Skok, Jane, Schlessinger, Joseph, Turk, Benjamin E., Calderwood, David A., Philips, Mark R.

“…Inhibiting membrane association of RAS has long been considered a rational approach to anticancer therapy, which led to the development of farnesyltransferase…”
Get full text

Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT by Court, Helen, Ahearn, Ian M, Amoyel, Marc, Bach, Erika A, Philips, Mark R

“…Isoprenylcysteine carboxyl methyltransferase (ICMT) methylesterifies C-terminal prenylcysteine residues of CaaX proteins and some RAB GTPases. Deficiency of…”
Get full text

PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis by Bivona, Trever G, Quatela, Steven E, Bodemann, Brian O, Ahearn, Ian M, Soskis, Michael J, Mor, Adam, Miura, John, Wiener, Heidi H, Wright, Latasha, Saba, Shahryar G, Yim, Duke, Fein, Adam, Pérez de Castro, Ignacio, Li, Chi, Thompson, Craig B, Cox, Adrienne D, Philips, Mark R

“…K-Ras associates with the plasma membrane (PM) through farnesylation that functions in conjunction with an adjacent polybasic sequence. We show that…”
Get full text

NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane by Ahearn, Ian M, Court, Helen R, Siddiqui, Farid, Abankwa, Daniel, Philips, Mark R

“…Isoprenylcysteine carboxyl methyltransferase (ICMT) is the third of three enzymes that sequentially modify the C-terminus of CaaX proteins, including RAS…”
Get full text

Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1 by Philips, Mark R, Bivona, Trever G, Pérez de Castro, Ignacio, Ahearn, Ian M, Grana, Theresa M, Chiu, Vi K, Lockyer, Peter J, Cullen, Peter J, Pellicer, Angel, Cox, Adrienne D

“…Ras proteins regulate cellular growth and differentiation, and are mutated in 30% of cancers. We have shown recently that Ras is activated on and transmits…”
Get full text

Rap1 Up-Regulation and Activation on Plasma Membrane Regulates T Cell Adhesion by Bivona, Trever G., Wiener, Heidi H., Ahearn, Ian M., Silletti, Joseph, Chiu, Vi K., Philips, Mark R.

“…Rap1 and Ras are closely related GTPases that share some effectors but have distinct functions. We studied the subcellular localization of Rap1 and its sites…”
Get full text

Linear atrophoderma of Moulin by Ahearn, Ian M, Gittler, Julia, Shvartsbeyn, Marianna, Meehan, Shane A, Pomeranz, Miriam Keltz

“…We present a 40-year-old woman with asymptomatic, linear, hyperpigmented atrophic plaques in a Blaschkoid distribution on the right back and right upper…”
Get full text

Primary cutaneous follicle-center lymphoma by Ahearn, Ian M, Hu, Stephanie W, Meehan, Shane A, Latkowski, Jo-Ann

Get full text

Metabolic labeling of Ras with tritiated palmitate to monitor palmitoylation and depalmitoylation by Tsai, Frederick D, Wynne, Joseph P, Ahearn, Ian M, Philips, Mark R

“…Metabolic labeling with tritiated palmitate is a direct method for monitoring posttranslational modification of Ras proteins with this fatty acid. Advances in…”
Get more information

Analysis of K-Ras phosphorylation, translocation, and induction of apoptosis by Quatela, Steven E, Sung, Pamela J, Ahearn, Ian M, Bivona, Trever G, Philips, Mark R

“…K-Ras is a member of a family of proteins that associate with the plasma membrane by virtue of a lipid modification that inserts into the membrane and a…”
Get more information

Primary cutaneous follicle-center lymphoma by Ahearn, Ian M, Hu, Stephanie W, Meehan, Shane A, Latkowski, Jo-Ann

“…We present a 64-year-old man with a three-year history of pruritic, pink papules and nodules of the face who was found to have a clonal lymphoproliferative…”
Get full text

Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit by Ranganathan, Velvizhi, Heine, Walter F., Ciccone, David N., Rudolph, Karl L., Wu, Xiaohua, Chang, Sandy, Hai, Hua, Ahearn, Ian M., Livingston, David M., Resnick, Igor, Rosen, Fred, Seemanova, Eva, Jarolim, Petr, DePinho, Ronald A., Weaver, David T.

“…Nijmegen breakage syndrome (NBS) is a rare human disease displaying chromosome instability, radiosensitivity, cancer predisposition, immunodeficiency, and…”
Get full text