Reduced caudate nuclei volumes in patients with congenital central hypoventilation syndrome

Abstract Congenital central hypoventilation syndrome (CCHS) children show cognitive and affective deficits, in addition to state-specific loss of respiratory drive. The caudate nuclei serve motor, cognitive, and affective roles, and show structural deficits in CCHS patients, based on gross voxel-bas...

Full description

Saved in:

Bibliographic Details
Published in:	Neuroscience Vol. 163; no. 4; pp. 1373 - 1379
Main Authors:	Kumar, R, Ahdout, R, Macey, P.M, Woo, M.A, Avedissian, C, Thompson, P.M, Harper, R.M
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Ltd 10-11-2009 Elsevier
Subjects:	Adolescent basal ganglia Biological and medical sciences brain Caudate Nucleus - pathology Child cognition Female Functional Laterality Fundamental and applied biological sciences. Psychology Humans Hypoventilation - pathology hypoxia Imaging, Three-Dimensional Magnetic Resonance Imaging Male Multivariate Analysis Neurology Organ Size striatum Syndrome Vertebrates: nervous system and sense organs Young Adult hypoxia magnetic resonance imaging congenital central hypoventilation syndrome basal ganglia field-of-view echo-time cognition MANCOVA ICC proton-density brain FOV multivariate analysis of covariance TE 3D three-dimensional striatum CCHS PD PPT intraclass correlation coefficient pedunculopontine tegmentum TR repetition-time Human Oxygen Central nervous system Environmental factor Cognition Corpus striatum Basal ganglion Nuclear magnetic resonance imaging Encephalon Hypoxia
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Abstract Congenital central hypoventilation syndrome (CCHS) children show cognitive and affective deficits, in addition to state-specific loss of respiratory drive. The caudate nuclei serve motor, cognitive, and affective roles, and show structural deficits in CCHS patients, based on gross voxel-based analytic procedures. However, the magnitude and regional sites of caudate injury in CCHS are unclear. We assessed global caudate nuclei volumes with manual volumetric procedures, and regional volume differences with three-dimensional surface morphometry in 14 CCHS (mean age±SD: 15.1±2.3 years; 8 male) and 31 control children (15.1±2.4 years; 17 male) using brain magnetic resonance imaging (MRI). Two high-resolution T1-weighted image series were collected using a 3.0 Tesla MRI scanner; images were averaged and reoriented (rigid-body transformation) to common space. Both left and right caudate nuclei were outlined in the reoriented images, and global volumes calculated; surface models were derived from manually-outlined caudate structures. Global caudate nuclei volume differences between groups were evaluated using a multivariate analysis of covariance (covariates: age, gender, and total intracranial volume). Both left and right caudate nuclei volumes were significantly reduced in CCHS over control subjects (left, 4293.45±549.05 vs. 4626.87±593.41 mm3 , P <0.006; right, 4376.29±565.42 vs. 4747.81±578.13 mm3 , P <0.004). Regional deficits in CCHS caudate volume appeared bilaterally, in the rostral head, ventrolateral mid, and caudal body. Damaged caudate nuclei may contribute to CCHS neuropsychological and motor deficits; hypoxic processes, or maldevelopment in the condition may underlie the injury.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Section Editor: Dr. Miles Herkenham, Bethesda, MD, USA.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2009.07.038