Prognostic value of static and dynamic biomarkers in COVID-19 patients: a prospective cohort study

Objective. The aim of this study was to analyze in a prospective cohort of hospitalized COVID-19 patients the relationship between biomarkers levels and their variation within the first 4 days since admission, and prognosis. Material and methods. Prospective cohort study. Individuals with confirmed...

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Published in:	Revista española de quimioterapia Vol. 34; no. 4; pp. 308 - 314
Main Authors:	Hormanstorfer, Macarena, Borodowski, Héctor, Nelson, Kevin, Patrosso, María Jazmín, Kolland, Ingrid, Italiano, Luca, Casali, Verónica Inés, Barrios, Paloma Victoria, Hernández Sepulveda, Luis Felipe, Tanaro, María Eugenia, Aldana Petraglia, Cynthia, Aguzezko, Alexia Denisse, Luna, Cecilia, Mouse, Carlos, Gandino, Ignacio, Presas, Jose Luis, Paulin, Francisco
Format:	Journal Article
Language:	English
Published:	Sociedad Española de Quimioterapia 01-08-2021
Subjects:	Original
Online Access:	Get full text
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Summary:	Objective. The aim of this study was to analyze in a prospective cohort of hospitalized COVID-19 patients the relationship between biomarkers levels and their variation within the first 4 days since admission, and prognosis. Material and methods. Prospective cohort study. Individuals with confirmed diagnosis of covid-19 admitted in our hospital were included. Blood samples were obtained systematically on days 1 and 4 of hospitalization. Levels of RCP, LDH, Ferritin and D-dimer, together with platelets, lymphocytes and neutrophils counts were measured. A combined outcome that included ICU admission and death was considered the primary outcome. Logistic regression analysis was performed. Results. We included 335 patients with confirmed COVID-19. During their hospitalization, 23 (6.8%) needed ICU admission, and 10 (2.9%) died. In the multivariate analysis, a value of RCP greater than 10 mg/dl (OR 8.69, CI95% 1.45-52), an increase in RCP greater than 20% (OR 26.08, CI 95% 3.21-211.3), an increase in LDH greater than 20% (OR 6.29, CI 95% 1.84-21.44), a count of lymphocytes lower than 1500/mm3 (OR 2.74, CI 95% 1.04-7.23), a D-dimer value greater than 550 ng/ml (OR 9.8, CI 95% 1.78-53.9) and a neutrophil/lymphocyte index greater than 3(OR 4.5, CI 95% 1.43-14.19) were all associated with the primary outcome. Conclusion. Our study shows that the utilization of static and dynamic biomarkers may represent an important tool to assess prognosis of COVID-19 patients.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0214-3429 1988-9518
DOI:	10.37201/req/141.2020