Search Results - "Aguirrebengoa, Marion"

Histone demethylase KDM5A regulates the ZMYND8-NuRD chromatin remodeler to promote DNA repair by Gong, Fade, Clouaire, Thomas, Aguirrebengoa, Marion, Legube, Gaëlle, Miller, Kyle M

“…Upon DNA damage, histone modifications are dynamically reshaped to accommodate DNA damage signaling and repair within chromatin. In this study, we report the…”
Get full text

Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations by Cohen, Sarah, Puget, Nadine, Lin, Yea-Lih, Clouaire, Thomas, Aguirrebengoa, Marion, Rocher, Vincent, Pasero, Philippe, Canitrot, Yvan, Legube, Gaëlle

“…Ataxia with oculomotor apraxia 2 (AOA-2) and amyotrophic lateral sclerosis (ALS4) are neurological disorders caused by mutations in the gene encoding for…”
Get full text

Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures by Clouaire, Thomas, Rocher, Vincent, Lashgari, Anahita, Arnould, Coline, Aguirrebengoa, Marion, Biernacka, Anna, Skrzypczak, Magdalena, Aymard, François, Fongang, Bernard, Dojer, Norbert, Iacovoni, Jason S., Rowicka, Maga, Ginalski, Krzysztof, Côté, Jacques, Legube, Gaëlle

“…Double-strand breaks (DSBs) are extremely detrimental DNA lesions that can lead to cancer-driving mutations and translocations. Non-homologous end joining…”
Get full text

Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes by Aymard, François, Aguirrebengoa, Marion, Guillou, Emmanuelle, Javierre, Biola M, Bugler, Beatrix, Arnould, Coline, Rocher, Vincent, Iacovoni, Jason S, Biernacka, Anna, Skrzypczak, Magdalena, Ginalski, Krzysztof, Rowicka, Maga, Fraser, Peter, Legube, Gaëlle

“…Capture Hi-C analysis reveals that DNA double-strand breaks within transcriptionally active regions of the human genome form clusters that exhibit delayed…”
Get full text

Integrated analysis of H2A.Z isoforms function reveals a complex interplay in gene regulation by Lamaa, Assala, Humbert, Jonathan, Aguirrebengoa, Marion, Cheng, Xue, Nicolas, Estelle, Côté, Jacques, Trouche, Didier

“…The H2A.Z histone variant plays major roles in the control of gene expression. In human, H2A.Z is encoded by two genes expressing two isoforms, H2A.Z.1 and…”
Get full text

Control of Gene Expression in Senescence through Transcriptional Read-Through of Convergent Protein-Coding Genes by Muniz, Lisa, Deb, Maharshi Krishna, Aguirrebengoa, Marion, Lazorthes, Sandra, Trouche, Didier, Nicolas, Estelle

“…Antisense RNAs are non-coding RNAs that can regulate their corresponding sense RNAs and are generally produced from specific promoters. We uncover here a…”
Get full text

p57Kip2 acts as a transcriptional corepressor to regulate intestinal stem cell fate and proliferation by Creff, Justine, Nowosad, Ada, Prel, Anne, Pizzoccaro, Anne, Aguirrebengoa, Marion, Duquesnes, Nicolas, Callot, Caroline, Jungas, Thomas, Dozier, Christine, Besson, Arnaud

“…p57Kip2 is a cyclin/CDK inhibitor and a negative regulator of cell proliferation. Here, we report that p57 regulates intestinal stem cell (ISC) fate and…”
Get full text

Purification of astrocyte subtype based on a double reporter mice approach for downstream transcription profiling by Aguirrebengoa, Marion, Ohayon, David

“…Characterizing the molecular signature of a cell subtype leads to a better understanding of cell diversity, as this molecular data can identify new cellular…”
Get full text

Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks by Caron, Pierre, Choudjaye, Jonathan, Clouaire, Thomas, Bugler, Béatrix, Daburon, Virginie, Aguirrebengoa, Marion, Mangeat, Thomas, Iacovoni, Jason S., Álvarez-Quilón, Alejandro, Cortés-Ledesma, Felipe, Legube, Gaëlle

“…DNA double-strand breaks (DSBs) elicit the so-called DNA damage response (DDR), largely relying on ataxia telangiectasia mutated (ATM) and DNA-dependent…”
Get full text

The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability by Salifou, Kader, Ray, Swagat, Verrier, Laure, Aguirrebengoa, Marion, Trouche, Didier, Panov, Konstantin I., Vandromme, Marie

“…The interplay between methylation and demethylation of histone lysine residues is an essential component of gene expression regulation and there is…”
Get full text

Reassessment of the involvement of Snord115 in the serotonin 2c receptor pathway in a genetically relevant mouse model by Hebras, Jade, Marty, Virginie, Personnaz, Jean, Mercier, Pascale, Krogh, Nicolai, Nielsen, Henrik, Aguirrebengoa, Marion, Seitz, Hervé, Pradere, Jean-Phillipe, Guiard, Bruno P, Cavaille, Jérôme

“…has been proposed to promote the activity of serotonin (HTR2C) receptor via its ability to base pair with its pre-mRNA and regulate alternative RNA splicing…”
Get full text

Transcriptome profiling of the Olig2-expressing astrocyte subtype reveals their unique molecular signature by Ohayon, David, Aguirrebengoa, Marion, Escalas, Nathalie, Jungas, Thomas, Soula, Cathy

“…Astrocytes are recognized to be a heterogeneous population of cells that differ morphologically, functionally, and molecularly. Whether this heterogeneity…”
Get full text

Circular ANRIL isoforms switch from repressors to activators of p15/CDKN2B expression during RAF1 oncogene-induced senescence by Muniz, Lisa, Lazorthes, Sandra, Delmas, Maxime, Ouvrard, Julien, Aguirrebengoa, Marion, Trouche, Didier, Nicolas, Estelle

“…Long non-coding RNAs (ncRNAs) are major regulators of gene expression and cell fate. The INK4 locus encodes the tumour suppressor proteins p15 INK4b , p16…”
Get full text

Morphogenesis is transcriptionally coupled to neurogenesis during peripheral olfactory organ development by Aguillon, Raphaël, Madelaine, Romain, Aguirrebengoa, Marion, Guturu, Harendra, Link, Sandra, Dufourcq, Pascale, Lecaudey, Virginie, Bejerano, Gill, Blader, Patrick, Batut, Julie

“…Sense organs acquire their distinctive shapes concomitantly with the differentiation of sensory cells and neurons necessary for their function. Although our…”
Get full text

A vlincRNA participates in senescence maintenance by relieving H2AZ-mediated repression at the INK4 locus by Lazorthes, Sandra, Vallot, Céline, Briois, Sébastien, Aguirrebengoa, Marion, Thuret, Jean-Yves, Laurent, Georges St, Rougeulle, Claire, Kapranov, Philipp, Mann, Carl, Trouche, Didier, Nicolas, Estelle

“…Non-coding RNAs (ncRNAs) play major roles in proper chromatin organization and function. Senescence, a strong anti-proliferative process and a major anticancer…”
Get full text

A POLD3/BLM dependent pathway handles DSBs in transcribed chromatin upon excessive RNA:DNA hybrid accumulation by Cohen, S., Guenolé, A., Lazar, I., Marnef, A., Clouaire, T., Vernekar, D. V., Puget, N., Rocher, V., Arnould, C., Aguirrebengoa, M., Genais, M., Firmin, N., Shamanna, R. A., Mourad, R., Bohr, V. A., Borde, V., Legube, G.

“…Transcriptionally active loci are particularly prone to breakage and mounting evidence suggests that DNA Double-Strand Breaks arising in active genes are…”
Get full text

p57 Kip2 acts as a transcriptional corepressor to regulate intestinal stem cell fate and proliferation by Creff, Justine, Nowosad, Ada, Prel, Anne, Pizzoccaro, Anne, Aguirrebengoa, Marion, Duquesnes, Nicolas, Callot, Caroline, Jungas, Thomas, Dozier, Christine, Besson, Arnaud

“…p57 is a cyclin/CDK inhibitor and a negative regulator of cell proliferation. Here, we report that p57 regulates intestinal stem cell (ISC) fate and…”
Get full text

A dual role of dLsd1 in oogenesis: regulating developmental genes and repressing transposons by Lepesant, Julie M J, Iampietro, Carole, Galeota, Eugenia, Augé, Benoit, Aguirrenbengoa, Marion, Mercé, Clemèntine, Chaubet, Camille, Rocher, Vincent, Haenlin, Marc, Waltzer, Lucas, Pelizzola, Mattia, Di Stefano, Luisa

“…Abstract The histone demethylase LSD1 is a key chromatin regulator that is often deregulated in cancer. Its ortholog, dLsd1 plays a crucial role in Drosophila…”
Get full text

Re-assessment of the involvement of Snord115 in the serotonin 2C receptor pathway in a genetically relevant mouse model by Hebras, Jade, Marty, Virginie, Personnaz, Jean, Mercier, Pascale, Krogh, Nicolai, Nielsen, Henrik, Aguirrebengoa, Marion, Seitz, Hervé, Pradere, Jean-Phillipe, Guiard, Bruno P, Cavaille, Jérôme

“…SNORD115 has been proposed to promote the activity of serotonin (HTR2C) receptor via its ability to base-pair with its pre-mRNA and regulate alternative RNA…”
Get full text

Genome wide mapping of long range contacts unveils DNA Double Strand Breaks clustering at damaged active genes by Aymard, François, Aguirrebengoa, Marion, Guillou, Emmanuelle, Javierre, Biola M, Bugler, Beatrix, Arnould, Coline, Rocher, Vincent, Iacovoni, Jason S, Biernacka, Anna, Skrzypczak, Magdalena, Ginalski, Krzysztof, Rowicka, Maga, Fraser, Peter, Legube, Gaëlle

“…The ability of DNA Double Strand Breaks (DSBs) to cluster in mammalian cells has been subjected to intense debate over the past few years. Here we used a high…”
Get full text