Search Results - "Aguirre‐Portolés, Cristina"

ABCA1 overexpression worsens colorectal cancer prognosis by facilitating tumour growth and caveolin‐1‐dependent invasiveness, and these effects can be ameliorated using the BET inhibitor apabetalone by Aguirre‐Portolés, Cristina, Feliu, Jaime, Reglero, Guillermo, Ramírez de Molina, Ana

“…At the time of diagnosis, 20% of patients with colorectal cancer present metastasis. Among individuals with primary lesions, 50% of them will develop distant…”
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ZIP9 Is a Druggable Determinant of Sex Differences in Melanoma by Aguirre-Portolés, Cristina, Payne, Riley, Trautz, Aspen, Foskett, J Kevin, Natale, Christopher A, Seykora, John T, Ridky, Todd W

“…Melanoma and most other cancers occur more frequently and have worse prognosis in males compared with females. Although sex steroids are thought to be…”
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PP2A-B55 phosphatase counteracts Ki-67-dependent chromosome individualization during mitosis by Sanz-Flores, María, Ruiz-Torres, Miguel, Aguirre-Portolés, Cristina, El Bakkali, Aicha, Salvador-Barberó, Beatriz, Villarroya-Beltri, Carolina, Ortega, Sagrario, Megías, Diego, Gerlich, Daniel W., Álvarez-Fernández, Mónica, Malumbres, Marcos

“…Cell cycle progression is regulated by the orderly balance between kinase and phosphatase activities. PP2A phosphatase holoenzymes containing the B55 family of…”
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Tpx2 Controls Spindle Integrity, Genome Stability, and Tumor Development by AGUIRRE-PORTOLES, Cristina, BIRD, Alexander W, HYMAN, Anthony, CANAMERO, Marta, DE CASTRO, Ignacio Pérez, MALUMBRES, Marcos

“…Tpx2 is a microtubule-associated protein that activates the cell-cycle kinase Aurora A and regulates the mitotic spindle. Overexpression of Tpx2 is associated…”
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Precision Nutrition for Targeting Lipid Metabolism in Colorectal Cancer by Aguirre-Portoles, Cristina, Fernandez, Lara P, Ramírez de Molina, Ana

“…Cancer is a multistage and multifactorial condition with genetic and environmental factors modulating tumorogenesis and disease progression. Nevertheless,…”
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SUMOylation modulates the function of Aurora-B kinase by Fernández-Miranda, Gonzalo, de Castro, Ignacio Pérez, Carmena, Mar, Aguirre-Portolés, Cristina, Ruchaud, Sandrine, Fant, Xavier, Montoya, Guillermo, Earnshaw, William C, Malumbres, Marcos

“…Aurora kinases are central regulators of mitotic-spindle assembly, chromosome segregation and cytokinesis. Aurora B is a member of the chromosomal passenger…”
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Requirements for Aurora-A in Tissue Regeneration and Tumor Development in Adult Mammals by DE CASTRO, Ignacio Pérez, AGUIRRE-PORTOLES, Cristina, FERNANDEZ-MIRANDA, Gonzalo, CANAMERO, Marta, COWLEY, Dale O, VAN DYKE, Terry, MALUMBRES, Marcos

“…Aurora-A is a kinase involved in the formation and maturation of the mitotic spindle and chromosome segregation. This kinase is frequently overexpressed in…”
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Safety and Efficacy of High-Dose Memory CD45RO+ Donor Lymphocyte Infusion in Pediatric Recipients after Hematopoietic Stem Cell Transplantation by Gasior Kabat, Mercedes, Li, Ying, Galán, Victor, Mozo, Yasmina, Sisinni, Luisa, Bueno-Sánchez, David, Corral, Dolores, Naik, Swati, Echecopar, Carlos, Aguirre-Portolés, Cristina, Al-Akioui-Sanz, Karima, De Paz, Raquel, Marcos, Antonio, Romero, Ana Belén, Talleur, Aimee, Yuste, Víctor Jiménez, Triplett, Brandon, Pérez-Martínez, Antonio

“…Memory T selected cells (CD45RA-/RO+) as donor lymphocyte infusion are less capable of producing alloreactivity and graft versus host disease (GvHD) compared…”
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Newer generations of multi-target CAR and STAb-T immunotherapeutics: NEXT CART Consortium as a cooperative effort to overcome current limitations by Martín-Antonio, Beatriz, Blanco, Belén, González-Murillo, África, Hidalgo, Laura, Minguillón, Jordi, Pérez-Chacón, Gema

“…Adoptive T cellular immunotherapies have emerged as relevant approaches for treating cancer patients who have relapsed or become refractory (R/R) to…”
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A SUMOylation Motif in Aurora-A: Implications for Spindle Dynamics and Oncogenesis by Pérez de Castro, Ignacio, Aguirre-Portolés, Cristina, Martin, Benedicte, Fernández-Miranda, Gonzalo, Klotzbucher, Andrea, Kubbutat, Michael H G, Megías, Diego, Arlot-Bonnemains, Yannick, Malumbres, Marcos

“…Aurora-A is a serine/threonine kinase that plays critical roles in centrosome maturation, spindle dynamics, and chromosome orientation and it is frequently…”
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