Search Results - "Aguinaga Andrés, David"

Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes by Baker, Nicola, Glover, Lucy, Munday, Jane C, Aguinaga Andrés, David, Barrett, Michael P, de Koning, Harry P, Horn, David

“…African trypanosomes cause sleeping sickness in humans, a disease that is typically fatal without chemotherapy. Unfortunately, drug resistance is common and…”
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Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs by Munday, Jane C, Eze, Anthonius A, Baker, Nicola, Glover, Lucy, Clucas, Caroline, Aguinaga Andrés, David, Natto, Manal J, Teka, Ibrahim A, McDonald, Jennifer, Lee, Rebecca S, Graf, Fabrice E, Ludin, Philipp, Burchmore, Richard J S, Turner, C Michael R, Tait, Andy, MacLeod, Annette, Mäser, Pascal, Barrett, Michael P, Horn, David, De Koning, Harry P

“…Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic…”
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Molecular and functional interaction between GPR18 and cannabinoid CB2 G-protein-coupled receptors. Relevance in neurodegenerative diseases by Reyes-Resina, Irene, Navarro, Gemma, Aguinaga, David, Canela, Enric I., Schoeder, Clara T., Załuski, Michał, Kieć-Kononowicz, Katarzyna, Saura, Carlos A., Müller, Christa E., Franco, Rafael

“…[Display omitted] GPR18, still considered an orphan receptor, may respond to endocannabinoids, whose canonical receptors are CB1 and CB2. GPR18 and CB2…”
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Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain by Navarro, Gemma, Cordomi, Arnau, Brugarolas, Marc, Moreno, Estefania, Aguinaga, David, Pnrez-Benito, Laura, Ferre, Sergi, Cortns, Antoni, Casado, Vicent, Mallol, Josefa, Canela, Enric I, Lluis, Carme, Pardo, Leonardo, McCormick, Peter J, Franco, Rafael

“…BACKGROUNDG-protein-coupled receptor (GPCR) heteromeric complexes have distinct properties from homomeric GPCRs, giving rise to new receptor functionalities…”
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Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs by Navarro, Gemma, Cordomí, Arnau, Zelman-Femiak, Monika, Brugarolas, Marc, Moreno, Estefania, Aguinaga, David, Perez-Benito, Laura, Cortés, Antoni, Casadó, Vicent, Mallol, Josefa, Canela, Enric I, Lluís, Carme, Pardo, Leonardo, García-Sáez, Ana J, McCormick, Peter J, Franco, Rafael

“…G-protein-coupled receptors (GPCRs), in the form of monomers or homodimers that bind heterotrimeric G proteins, are fundamental in the transfer of…”
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Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers by Navarro, Gemma, Moreno, Estefania, Bonaventura, Jordi, Brugarolas, Marc, Farré, Daniel, Aguinaga, David, Mallol, Josefa, Cortés, Antoni, Casadó, Vicent, Lluís, Carmen, Ferre, Sergi, Franco, Rafael, Canela, Enric, McCormick, Peter J

“…Under normal conditions the brain maintains a delicate balance between inputs of reward seeking controlled by neurons containing the D1-like family of dopamine…”
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Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine by Navarro, Gemma, Quiroz, César, Moreno-Delgado, David, Sierakowiak, Adam, McDowell, Kimberly, Moreno, Estefanía, Rea, William, Cai, Ning-Sheng, Aguinaga, David, Howell, Lesley A, Hausch, Felix, Cortés, Antonio, Mallol, Josefa, Casadó, Vicent, Lluís, Carme, Canela, Enric I, Ferré, Sergi, McCormick, Peter J

“…Release of the neuropeptides corticotropin-releasing factor (CRF) and orexin-A in the ventral tegmental area (VTA) play an important role in stress-induced…”
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Usefulness of identifying G-protein-coupled receptor dimers for diagnosis and therapy of neurodegenerative diseases and of gliomas by Reyes-Resina, Irene, Aguinaga Andrés, David, Labandeira García, José L, Lanciego, José Luis, Navarro Brugal, Gemma, Franco Fernández, Rafael

“…Immunochemical detection of G-protein-coupled receptors (GPCRs) in cells and tissues was a technical challenge for years. After the discovery of formation of…”
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Usefulness of identifying G-protein-coupled receptor dimers for diagnosis and therapy of neurodegenerative diseases and of gliomas by Reyes-Resina, Irene, Aguinaga, David, Labandeira-García, José Luis, Lanciego, José Luis, Navarro, Gemma, Franco, Rafael

“…Immunochemical detection of G-protein-coupled receptors (GPCRs) in cells and tissues was a technical challenge for years. After the discovery of formation of…”
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Cocaine blocks effects of hunger hormone, ghrelin, via interaction with neuronal sigma-1 receptors by Aguinaga Andrés, David, Medrano, Mireia, Cordomí, Arnau, Jiménez-Rosés, Mireia, Angelats, Edgar, Casanovas Ferrero, Mireia, Vega-Quiroga, Ignacio, Canela Campos, Enric I, Petrovic, Milos, Gysling, Katia, Pardo, Leonardo, Franco Fernández, Rafael, Navarro Brugal, Gemma

“…Despite ancient knowledge on cocaine appetite-suppressant action, the molecular basis of such fact remains unknown. Addiction/eating disorders (e.g., binge…”
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Cocaine Effects on Dopaminergic Transmission Depend on a Balance between Sigma-1 and Sigma-2 Receptor Expression by Aguinaga Andrés, David, Medrano, Mireia, Vega-Quiroga, Ignacio, Gysling, Katia, Canela Campos, Enric I, Navarro Brugal, Gemma, Franco Fernández, Rafael

“…gma σ1 and σ2 receptors are targets of cocaine. Despite sharing a similar name, the two receptors are structurally unrelated and their physiological role is…”
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Significant Role of the Truncated Ghrelin Receptor GHS-1Rb in Ghrelin-Induced Signaling in Neurons by Navarro Brugal, Gemma, Aguinaga Andrés, David, Angelats, Edgar, Medrano, Mireia, Moreno Guillén, Estefanía, Mallol Montero, Josefa, Cortés Tejedor, Antonio, Canela Campos, Enric I, Casadó, Vicent, McCormick, Peter J, Lluís i Biset, Carme, Ferré, Sergi

“…The truncated non-signaling ghrelin receptor GHS-R1b has been suggested to simply exert a dominant negative role in the trafficking and signaling of the full…”
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Significant Role of the Truncated Ghrelin Receptor GHS-1Rb in Ghrelin-Induced Signaling in Neurons by Navarro Brugal, Gemma, Aguinaga Andrés, David, Angelats, Edgar, Medrano, Mireia, Moreno Guillén, Estefanía, Mallol Montero, Josefa, Cortés Tejedor, Antonio, Canela Campos, Enric I, Casadó, Vicent, McCormick, Peter J, Lluís i Biset, Carme, Ferré, Sergi

“…The truncated non-signaling ghrelin receptor GHS-R1b has been suggested to simply exert a dominant negative role in the trafficking and signaling of the full…”
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Cocaine Effects on Dopaminergic Transmission Depend on a Balance between Sigma-1 and Sigma-2 Receptor Expression by Aguinaga, David, Medrano, Mireia, Vega-Quiroga, Ignacio, Gysling, Katia, Canela, Enric I, Navarro, Gemma, Franco, Rafael

“…Sigma σ and σ receptors are targets of cocaine. Despite sharing a similar name, the two receptors are structurally unrelated and their physiological role is…”
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N-methyl-D-aspartate receptor link to the MAP kinase pathway in cortical and hippocampal neurons and microglia is dependent on calcium sensors and is blocked by α-synuclein, tau, and phospho-tau in non-transgenic and transgenic APPSw,Ind mice by Franco Fernández, Rafael, Aguinaga Andrés, David, Reyes, I, Canela Campos, Enric I, Lillo, J, Tarutani, A, Hasegawa, M, Ser Badia, A. del, Rio, J. A. del, Kreutz, M. R, Saura, C. A, Navarro Brugal, Gemma

“…N-methyl-D-aspartate receptors (NMDARs) respond to glutamate to allow the influx of calcium ions and the signaling to the mitogen-activated protein kinase…”
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Neuronal Calcium and cAMP Cross-Talk Mediated by Cannabinoid CB1 Receptor and EF-Hand Calcium Sensor Interactions by Angelats, Edgar, Requesens, Marta, Aguinaga, David, Kreutz, Michael R., Franco, Rafael, Navarro, Gemma

“…Endocannabinoids are important players in neural development and function. They act via receptors, whose activation inhibits cAMP production. The aim of the…”
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Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine by Navarro Brugal, Gemma, Quiroz, César, Moreno-Delgado, David, Sierakowiak, Adam, McDowell, Kimberly, Moreno Guillén, Estefanía, Rea, William, Cai, Ning-Sheng, Aguinaga Andrés, David, Howell, Lesley A, Hausch, Felix, Cortés Tejedor, Antonio, Mallol Montero, Josefa, Casadó, Vicent, Lluís i Biset, Carme, Canela Campos, Enric I, Ferré, Sergi, McCormick, Peter J

“…Release of the neuropeptides corticotropin-releasing factor (CRF) and orexin-A in the ventral tegmental area (VTA) play an important role in stress-induced…”
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Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers by Navarro Brugal, Gemma, Moreno Guillén, Estefanía, Bonaventura, Jordi, Brugarolas Campillos, Marc, Farré, Daniel, Aguinaga Andrés, David, Mallol Montero, Josefa, Cortés Tejedor, Antonio, Casadó, Vicent, Lluís i Biset, Carme, Ferré, Sergi, Franco Fernández, Rafael, Canela Campos, Enric I, McCormick, Peter J

“…Under normal conditions the brain maintains a delicate balance between inputs of reward seeking controlled by neurons containing the D1-like family of dopamine…”
Get full text