Search Results - "Aguilera, Concepción M"
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Genetics of Lactose Intolerance: An Updated Review and Online Interactive World Maps of Phenotype and Genotype Frequencies
Published in Nutrients (03-09-2020)“…In humans the ability to digest milk lactose is conferred by a β-galactosidase enzyme called lactase-phlorizin hydrolase (LPH). While in some humans…”
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eXplainable Artificial Intelligence (XAI) for the identification of biologically relevant gene expression patterns in longitudinal human studies, insights from obesity research
Published in PLoS computational biology (01-04-2020)“…Until date, several machine learning approaches have been proposed for the dynamic modeling of temporal omics data. Although they have yielded impressive…”
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Elevated plasma succinate levels are linked to higher cardiovascular disease risk factors in young adults
Published in Cardiovascular diabetology (27-07-2021)“…Succinate is produced by both host and microbiota, with a key role in the interplay of immunity and metabolism and an emerging role as a biomarker for…”
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Sedentarism, Physical Activity, Steps, and Neurotrophic Factors in Obese Children
Published in Medicine and science in sports and exercise (01-11-2019)“…PURPOSEThis study aimed to examine the associations of sedentary time, physical activity (PA) and step-related behaviors with neurotrophic growth factors…”
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Alterations in plasma and tissue lipids associated with obesity and metabolic syndrome
Published in Clinical science (1979) (01-02-2008)“…The MS (metabolic syndrome) is a cluster of clinical and biochemical abnormalities characterized by central obesity, dyslipidaemia [hypertriglyceridaemia and…”
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Changes in Physical Activity Patterns from Childhood to Adolescence: Genobox Longitudinal Study
Published in International journal of environmental research and public health (02-10-2020)“…Longitudinal changes of physical activity (PA) from childhood into adolescence have not been accurately described yet for the Spanish population. The aim of…”
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Low Tissue Inhibitor of Metalloproteinases 3 and High Matrix Metalloproteinase 14 Levels Defines a Subpopulation of Highly Invasive Foam-Cell Macrophages
Published in Arteriosclerosis, thrombosis, and vascular biology (01-09-2008)“…OBJECTIVE—An excess of metalloproteinases (MMPs) over tissue inhibitors of metalloproteinases (TIMPs) may favor atherosclerotic plaque rupture. We compared…”
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Dietary Patterns and Their Association with Body Composition and Cardiometabolic Markers in Children and Adolescents: Genobox Cohort
Published in Nutrients (08-11-2020)“…Diet is a key factor for obesity development; however, limited data are available on dietary cluster analysis in children with obesity. We aimed to assess the…”
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The Vitamin D Decrease in Children with Obesity Is Associated with the Development of Insulin Resistance during Puberty: The PUBMEP Study
Published in Nutrients (15-12-2021)“…Obesity and cardiometabolic risk have been associated with vitamin D levels even in children. The objective of the present study was to evaluate the…”
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Leptin Receptor Gene Variant rs11804091 Is Associated with BMI and Insulin Resistance in Spanish Female Obese Children: A Case-Control Study
Published in International journal of molecular sciences (03-08-2017)“…Leptin is an endocrine hormone that has a critical role in body weight homoeostasis and mediates its effects via the leptin receptor (LEPR). Common…”
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Progression of metabolic syndrome and associated cardiometabolic risk factors from prepuberty to puberty in children: The PUBMEP study
Published in Frontiers in endocrinology (Lausanne) (19-12-2022)“…Metabolic syndrome (MetS) is a cluster of clinical and metabolic alterations related to the risk of cardiovascular diseases (CVD). Metabolic changes occurring…”
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Inflammatory biomarkers and brain health indicators in children with overweight and obesity: The ActiveBrains project
Published in Brain, behavior, and immunity (01-10-2019)“…•This is the first study examining inflammation and brain volumes in children.•Inflammation might influence brain health in children with overweight or…”
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Antioxidants and Oxidative Stress in Children: Influence of Puberty and Metabolically Unhealthy Status
Published in Antioxidants (01-07-2020)“…Oxidative stress could help explain the relationship between childhood obesity and a metabolically unhealthy (MU) status. Moreover, puberty could also…”
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The effects of a 20-week exercise program on blood-circulating biomarkers related to brain health in overweight or obese children: The ActiveBrains project
Published in Journal of sport and health science (01-03-2023)“…•Candidate biomarkers (i.e., brain-derived neurotrophic factor, β-hydroxybutyrate, cathepsin B, kynurenine, fibroblast growth factor 21, soluble vascular cell…”
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Energy Dense Salty Food Consumption Frequency Is Associated with Diastolic Hypertension in Spanish Children
Published in Nutrients (09-04-2020)“…High blood pressure (BP) is a risk factor for cardiovascular disease and sodium consumption is related to high BP. Moreover, sugar-sweetened beverages (SSB)…”
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Endometrial whole metabolome profile at the receptive phase: influence of Mediterranean Diet and infertility
Published in Frontiers in endocrinology (Lausanne) (2023)“…Several metabolite classes have been identified in human endometrium, including lipids, nucleotides, amino acids, organic acids, and sugars. The first studies…”
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Strong Associations Exist among Oxidative Stress and Antioxidant Biomarkers in the Circulating, Cellular and Urinary Anatomical Compartments in Guatemalan Children from the Western Highlands
Published in PloS one (20-01-2016)“…A series of antioxidant enzymes and non-enzymatic compounds act to protect cells from uncontrolled propagation of free radicals. It is poorly understood,…”
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Height‐based equations as screening tools for high blood pressure in pediatric practice, the GENOBOX study
Published in The journal of clinical hypertension (Greenwich, Conn.) (01-06-2022)“…Due to the absence of easily applicable cut‐off points to determine high blood pressure or hypertension in children, as in the adult population, blood pressure…”
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Distinct whole-blood transcriptome profile of children with metabolic healthy overweight/obesity compared to metabolic unhealthy overweight/obesity
Published in Pediatric research (01-05-2021)“…Background Youth populations with overweight/obesity (OW/OB) exhibit heterogeneity in cardiometabolic health phenotypes. The underlying mechanisms for those…”
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Inflammatory markers and bone mass in children with overweight/obesity: the role of muscular fitness
Published in Pediatric research (01-01-2020)“…Objectives To examine which inflammatory markers are associated with bone mass and whether this association varies according to muscular fitness in children…”
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