Search Results - "Aguilera, Alexya N."

APOBEC3A catalyzes mutation and drives carcinogenesis in vivo by Law, Emily K, Levin-Klein, Rena, Jarvis, Matthew C, Kim, Hyoung, Argyris, Prokopios P, Carpenter, Michael A, Starrett, Gabriel J, Temiz, Nuri A, Larson, Lindsay K, Durfee, Cameron, Burns, Michael B, Vogel, Rachel I, Stavrou, Spyridon, Aguilera, Alexya N, Wagner, Sandra, Largaespada, David A, Starr, Timothy K, Ross, Susan R, Harris, Reuben S

“…The APOBEC3 family of antiviral DNA cytosine deaminases is implicated as the second largest source of mutation in cancer. This mutational process may be a…”
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DDX41 is required for cGAS-STING activation against DNA virus infection by Singh, Ravi Shankar, Vidhyasagar, Venkatasubramanian, Yang, Shizhuo, Arna, Ananna Bhadra, Yadav, Manisha, Aggarwal, Aanchal, Aguilera, Alexya N., Shinriki, Satoru, Bhanumathy, Kalpana Kalyanasundaram, Pandey, Kannupriya, Xu, Aizhang, Rapin, Noreen, Bosch, Mark, DeCoteau, John, Xiang, Jim, Vizeacoumar, Franco J., Zhou, Yan, Misra, Vikram, Matsui, Hirotaka, Ross, Susan R., Wu, Yuliang

“…Upon binding double-stranded DNA (dsDNA), cyclic GMP-AMP synthase (cGAS) is activated and initiates the cGAS-stimulator of IFN genes (STING)-type I interferon…”
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IFI207, a young and fast-evolving protein, controls retroviral replication via the STING pathway by Moran, Eileen A, Salas-Briceno, Karen, Zhao, Wenming, Enya, Takuji, Aguilera, Alexya N, Acosta, Ivan, Alonzo, Francis, Kiani, Dara, Behnsen, Judith, Alvarez, Catalina, Keane, Thomas M, Adams, David J, Lilue, Jingtao, Ross, Susan R

“…Mammalian AIM-2-like receptor (ALR) proteins bind nucleic acids and initiate production of type I interferons or inflammasome assembly, thereby contributing to…”
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DDX41 Recognizes RNA/DNA Retroviral Reverse Transcripts and Is Critical for In Vivo Control of Murine Leukemia Virus Infection by Stavrou, Spyridon, Aguilera, Alexya N, Blouch, Kristin, Ross, Susan R

“…Host recognition of viral nucleic acids generated during infection leads to the activation of innate immune responses essential for early control of virus…”
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COL11A2 as a candidate gene for vertebral malformations and congenital scoliosis by Rebello, Denise, Wohler, Elizabeth, Erfani, Vida, Li, Guozhuang, Aguilera, Alexya N, Santiago-Cornier, Alberto, Zhao, Sen, Hwang, Steven W, Steiner, Robert D, Zhang, Terry Jianguo, Gurnett, Christina A, Raggio, Cathleen, Wu, Nan, Sobreira, Nara, Giampietro, Philip F, Ciruna, Brian

“…Abstract Human vertebral malformations (VMs) have an estimated incidence of 1/2000 and are associated with significant health problems including congenital…”
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Metabolic subsets of plasma cells and their turnover in the marrow by Wols, Heather A Minges, Aguilera, Alexya N, Witte, Pamela L

“…The ability of long-lived plasma cells (LLPC) to maintain longevity and avoid metabolic burnout has been largely unexplored until recently. Our lab has shown…”
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The impact of hypoxia on metabolic subsets of bone marrow plasma cells by Minges Wols, Heather A, Aguilera, Alexya N., Witte, Pamela L

“…The metabolic stress of being an antibody-secreting cell is likely great. Indeed, existing literature suggests short-lived plasma cells (SLPC) die due to high…”
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DDX41 Recognizes RNA/DNA Retroviral Reverse Transcripts and Is Critical for italic toggle="yes">In Vivo /italic> Control of Murine Leukemia Virus Infection by Spyridon Stavrou, Alexya N. Aguilera, Kristin Blouch, Susan R. Ross

“…ABSTRACT Host recognition of viral nucleic acids generated during infection leads to the activation of innate immune responses essential for early control of…”
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