In Vitro and In Vivo Wound Healing and Anti-Inflammatory Activities of Babassu Oil (Attalea speciosa Mart. Ex Spreng., Arecaceae)

In Vitro and In Vivo Wound Healing and Anti-Inflammatory Activities of Babassu Oil (Attalea speciosa Mart. Ex Spreng., Arecaceae)

Babassu (Attalea speciosa Mart. ex Spreng., Arecaceae) is a palm tree endemic to Brazil and found mainly in the borders of Amazon forest, where the harvesting of its fruits is an important source of income for more than 300,000 people. Among the communities of coconut breakers women, babassu oil is...

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Published in:Evidence-based complementary and alternative medicine Vol. 2020; no. 2020; pp. 1 - 10
Main Authors: Silva, Teresinha G., Martins, René D., Aguiar Júnior, Francisco Carlos A., Ximenes, Rafael M., Albuquerque, Julianna F. C., Correia, Maria Tereza S., da Silva, Márcia Vanusa, Silva, Camila Joyce A., Rodrigues, Maria de Fátima, Santos, Simone Maria dos, Silva, José Wellinton da, Santos, José Alex A., Melo, Cristiane M. L.
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Publishing Corporation 2020
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Subjects:
Analysis
Animals
Anti-inflammatory agents
Anti-inflammatory drugs
Arecaceae
Attalea
Blood vessels
Care and treatment
Cell adhesion & migration
Collagen
Cytokines
Dermatologic agents
Dermatology
Ear
Edema
Fatty acids
Fibroblasts
Formulae, receipts, prescriptions
Hyperplasia
Inflammation
Interleukin 6
Leukocyte migration
Lipopolysaccharides
Macrophages
Nitric oxide
Oils & fats
Peritoneum
Peroxidase
Skin
Wound healing
Wounds and injuries
Brazil
United States > US
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Summary:Babassu (Attalea speciosa Mart. ex Spreng., Arecaceae) is a palm tree endemic to Brazil and found mainly in the borders of Amazon forest, where the harvesting of its fruits is an important source of income for more than 300,000 people. Among the communities of coconut breakers women, babassu oil is used in culinary, as fuel, and mostly as medicinal oil for the treatment of skin wounds and inflammation. This study aimed to evaluate in vitro and in vivo the wound healing effects of babassu oil. In vitro, babassu oil increased the migration of L929 fibroblasts, inhibited the production of nitric oxide by LPS-stimulated peritoneal macrophages, and increased the levels of INF-γ and IL-6 cytokines production. In vivo, babassu oil accelerated the healing process in a full-thickness splinted wound model, by an increase in the fibroblasts number, blood vessels, and collagen deposition in the wounds. The babassu oil also increased the recruitment of inflammatory cells into the wound site and showed an anti-inflammatory effect in a chronic ear edema model, reducing ear thickness, epidermal hyperplasia, and myeloperoxidase activity. Thus, these data corroborate the use of babassu oil in folk medicine as a remedy to treat skin wounds.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Academic Editor: Rômulo Dias Novaes
ISSN:1741-427X
1741-4288
DOI:10.1155/2020/8858291