Zika and Chikungunya Virus and Risk for Venous Thromboembolism

A variety of viral infections are associated with hypercoagulable states and may be linked to the development of deep venous thrombosis and pulmonary embolism. The Zika and Chikungunya viral infections spread through the South and Central American continents, moving to North America in 2016, with se...

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Bibliographic Details
Published in:	Clinical and applied thrombosis/hemostasis Vol. 25; p. 1076029618821184
Main Authors:	Ramacciotti, Eduardo, Agati, Leandro B., Aguiar, Valéria C. R., Wolosker, Nelson, Guerra, João C., de Almeida, Roque P., Alves, Juliana Cardoso, Lopes, Renato D., Wakefield, Thomas W., Comerota, Anthony J., Walenga, Jeanine, Fareed, Jawed
Format:	Journal Article
Language:	English
Published:	Los Angeles, CA SAGE Publications 01-01-2019 SAGE PUBLICATIONS, INC SAGE Publishing
Subjects:	Chikungunya virus Guillain-Barre syndrome Health risk assessment Hormone replacement therapy Infections Original Thromboembolism Thrombosis Viral infections Zika virus deep venous thrombosis Zika virus Chikungunya virus
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Summary:	A variety of viral infections are associated with hypercoagulable states and may be linked to the development of deep venous thrombosis and pulmonary embolism. The Zika and Chikungunya viral infections spread through the South and Central American continents, moving to North America in 2016, with severe cases of polyarthralgia, fever, and Guillain-Barré syndrome leading eventually to death. A decreased trend for both infections was reported in the first quarter of 2017. In this article, we report the possible association of venous thromboembolic events associated with Zika infection. After 2 cases of deep venous thrombosis in patients with acute Zika infections, D-dimer levels were measured in 172 consecutive patients who presented to the emergency department of a university hospital in an endemic region of Brazil with either Zika or Chikungunya infections confirmed by polymerase chain reaction tests. D-dimer levels were increased in 19.4% of 31 patients with Zika and in 63.8% of 141 patients with Chikungunya infections. The mechanisms behind this association are yet to be elucidated as well as the potential for venous thromboembolism prevention strategies for in-hospital patients affected by Zika and Chikungunya infections.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1076-0296 1938-2723
DOI:	10.1177/1076029618821184