Search Results - "Aguennouz, M’hammed"
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Serum levels of miRNA-21-5p in vitiligo patients and effects of miRNA-21-5p on SOX5, beta-catenin, CDK2 and MITF protein expression in normal human melanocytes
Published in Journal of dermatological science (01-01-2021)“…•The expression of serum miR-21-5p in vitiligo patients is significantly increased.•Serum miR-21-5p is directly and significantly correlated with vitiligo…”
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Hippo signaling pathway is altered in Duchenne muscular dystrophy
Published in PloS one (10-10-2018)“…Hippo signaling pathway is considered a key regulator of tissue homeostasis, cell proliferation, apoptosis and it is involved in cancer development. In…”
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Charcot-Marie-Tooth disease: experience from a large Italian tertiary neuromuscular center
Published in Neurological sciences (01-05-2020)“…Introduction Charcot-Marie-Tooth (CMT) disease is the most common inherited neuromuscular disease. Thanks to the advances of the latest generation sequencing,…”
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Nusinersen Modulates Proteomics Profiles of Cerebrospinal Fluid in Spinal Muscular Atrophy Type 1 Patients
Published in International journal of molecular sciences (21-04-2021)“…Spinal muscular atrophy (SMA) type 1 is a severe infantile autosomal-recessive neuromuscular disorder caused by a survival motor neuron 1 gene ( ) mutation and…”
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The emerging links between immunosenescence in innate immune system and neurocryptococcosis
Published in Frontiers in immunology (20-08-2024)“…Immunosenescence refers to the age-related progressive decline of immune function contributing to the increased susceptibility to infectious diseases in older…”
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miR-21 and 221 upregulation and miR-181b downregulation in human grade II–IV astrocytic tumors
Published in Journal of neuro-oncology (01-07-2009)“…MicroRNAs (miRNAs) are small noncoding regulatory RNAs that reduce stability and/or translation of fully or partially sequence-complementary target mRNAs…”
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Circulating miRNAs expression as potential biomarkers of mild traumatic brain injury
Published in Molecular biology reports (01-04-2020)“…TBI is the main cause of death and disability in individuals aged 1–45 in Western countries. One of the main challenges of TBI at present is the lack of…”
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Matrix Metalloproteinase 9 and Transglutaminase 2 Expression at the Ocular Surface in Patients with Different Forms of Dry Eye Disease
Published in Ophthalmology (Rochester, Minn.) (2015)“…Objective To evaluate the expression of matrix metalloproteinase 9 (MMP9) and transglutaminase 2 (TG2) in different forms of dry eye. Design Case control…”
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Role of Erythropoietin in Cerebral Glioma: An Innovative Target in Neuro-Oncology
Published in World neurosurgery (01-11-2019)“…Erythropoietin (EPO) is a cytokine primarily involved in the regulation of erythropoiesis. In response to hypoxia-ischemia, hypoxia-inducible factor 1 induces…”
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Circulating microRNAs Profile in Patients With Transthyretin Variant Amyloidosis
Published in Frontiers in molecular neuroscience (23-06-2020)“…Transthyretin variant amyloidosis (ATTRv) is a rare autosomal dominant disease characterized by the accumulation of amyloid in many organs, mostly causing a…”
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Methylome Analysis in Nonfunctioning and GH-Secreting Pituitary Adenomas
Published in Frontiers in endocrinology (Lausanne) (30-03-2022)“…Pituitary adenomas (PAs), usually benign lesions, can sometimes present with "aggressive" features (rapid growth, local invasiveness, scarce response to…”
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A Phase 1/2 Study of Flavocoxid, an Oral NF-κB Inhibitor, in Duchenne Muscular Dystrophy
Published in Brain sciences (16-01-2021)“…Flavocoxid is a blended extract containing baicalin and catechin with potent antioxidant and anti-inflammatory properties due to the inhibition of the…”
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miRNA regulation of Sirtuin-1 expression in human astrocytoma
Published in Oncology letters (01-10-2016)“…Sirtuins are a family of 7 histone deacetylases largely involved in the regulation of cell proliferation, survival and death. The role of sirtuins in…”
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Modulation of neuronal nitric oxide synthase and apoptosis by the isoflavone genistein in Mdx mice
Published in BioFactors (Oxford) (01-09-2015)“…Dystrophin lack in DMD causes neuronal nitric oxide synthase (nNOS) membrane delocalization which in turn promotes functional muscle ischemia, and exacerbates…”
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microRNA-10 and -221 modulate differential expression of Hippo signaling pathway in human astroglial tumors
Published in Cancer treatment and research communications (2020)“…•Gliomas are highly invasive and poor survival vascular neoplasms.•YAP1 has been reported to function either as an oncogene or tumor suppressor.•YAP1 is…”
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Extensive Contact Lens Wear Modulates Expression of miRNA-320 and miRNA-423-5p in the Human Corneal Epithelium: Possible Biomarkers of Corneal Health and Environmental Impact
Published in Genes (20-06-2024)“…The identification of new biomarkers of ocular diseases is nowadays of outmost importance both for early diagnosis and treatment. Epigenetics is a rapidly…”
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Effect of exercise on telomere length and telomere proteins expression in mdx mice
Published in Molecular and cellular biochemistry (01-07-2020)“…In Duchenne muscular dystrophy (DMD), telomere shortening has been postulated to contribute to the failure of regenerative activity promoting the premature…”
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Thyroid Cancer Persistence in Patients with Unreliable Thyroglobulin Measurement: Circulating microRNA as Candidate Alternative Biomarkers
Published in Cancers (16-11-2022)“…We aimed to evaluate the role of circulating miRNAs as a biomarker of the persistence of papillary thyroid cancer (PTC) in patients with an "uninformative"…”
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New Mutations in TK2 Gene Associated With Mitochondrial DNA Depletion
Published in Pediatric neurology (01-03-2006)“…Mitochondrial deoxyribonucleic acid depletion syndromes are autosomal recessive disorders characterized by a reduction of the amount of mitochondrial…”
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CXCL12/CXCR4 axis supports mitochondrial trafficking in tumor myeloma microenvironment
Published in Oncogenesis (New York, NY) (21-01-2022)“…Mesenchymal stromal cells (MSCs) within the protective microenvironment of multiple myeloma (MM) promote tumor growth, confer chemoresistance and support…”
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