Inactivation of Enveloped Bovine Viral Diarrhea Virus and Non-Enveloped Porcine Parvovirus Using Low-Pressure Non-Thermal Plasma

As the worldwide population has been experiencing since 2020, viruses represent a serious threat to global well-being. To avoid viral transmission through surgery or medical examination, sterilization of medical material is needed. From emerging sterilization processes, the use of non-thermal plasma...

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Bibliographic Details
Published in:	Life (Basel, Switzerland) Vol. 11; no. 12; p. 1292
Main Authors:	Le Bras, Florian, Carré, Gaëlle, Aguemon, Yasmina, Colin, Marius, Gellé, Marie-Paule
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 24-11-2021 MDPI
Subjects:	Atmospheric pressure Bacteria Bovine viral diarrhea virus Cattle Coronaviruses COVID-19 Diarrhea Disinfection Engineering Sciences Gamma rays Gram-positive bacteria Hepatitis C Inactivation Life Sciences Low pressure Magnetic fields Medical equipment Medical materials Microbiology and Parasitology Microorganisms non-thermal plasma Oxygen plasma Parvoviruses Physical examinations Plasma Plasmas Plasmas (physics) Polymers porcine parvovirus Radiation Statistical analysis Sterilization Thermal plasmas Virology virus inactivation Viruses Bovine viral diarrhea virus oxygen plasma oxygen-argon plasma porcine parvovirus low pressure virus inactivation non-thermal plasma
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Summary:	As the worldwide population has been experiencing since 2020, viruses represent a serious threat to global well-being. To avoid viral transmission through surgery or medical examination, sterilization of medical material is needed. From emerging sterilization processes, the use of non-thermal plasma (NTP) arises as a promising technique to efficiently reduce microbial burden on medical devices, including new complex polymers as thermosensitive ones. Thus, we evaluated the antiviral efficacy of a low-pressure NTP process taking place in a sealed bag. For this purpose, two different plasmas, O 100% plasma and Ar 80%-O 20% plasma, were tested against two viruses: the bovine viral diarrhea virus and the porcine parvovirus, surrogates of human hepatitis C virus and human parvovirus B19, respectively. The efficacy of both NTP treatments on viral load can be detected after only five minutes. Moreover, the longer the NTP treatments last, the more the load decreases. The most effective load reduction was obtained with a 120-min O plasma treatment inducing a minimum of four-log viral load reduction. So, this process demonstrated strong virucidal capacity inside a sealed bag and represents a very interesting opportunity in the field of fragile medical devices sterilization or disinfection.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2075-1729 2075-1729
DOI:	10.3390/life11121292