Search Results - "Aguayo, L. G."

High ethanol sensitive glycine receptors regulate firing in D1 medium spiny neurons in the nucleus accumbens by Gallegos, S., Muñoz, B., Araya, A., Aguayo, L.G.

“…Inhibitory glycine receptors (GlyRs) are widely expressed in spinal cord and brain stem. They are also expressed in the nucleus Accumbens (nAc) where they have…”
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Aβ oligomers induce glutamate release from hippocampal neurons by Brito-Moreira, J, Paula-Lima, A C, Bomfim, T R, Oliveira, F B, Sepúlveda, F J, De Mello, F G, Aguayo, L G, Panizzutti, R, Ferreira, S T

“…Soluble oligomers of the amyloid-β peptide (AβOs) accumulate in Alzheimer's disease (AD) brain and have been implicated in mechanisms of pathogenesis. The…”
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Reduced sedation and increased ethanol consumption in knock-in mice expressing an ethanol insensitive alpha 2 subunit of the glycine receptor by Gallegos, S, San Martin, L, Araya, A, Lovinger, D M, Homanics, G E, Aguayo, L G

“…Previous studies have shown the presence of several subunits of the inhibitory glycine receptor (GlyR) in the reward system, specifically in medium spiny…”
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Regulation of glycinergic and GABAergic synaptogenesis by brain-derived neurotrophic factor in developing spinal neurons by Carrasco, M.A, Castro, P, Sepulveda, F.J, Tapia, J.C, Gatica, K, Davis, M.I, Aguayo, L.G

“…Abstract Brain-derived neurotrophic factor (BDNF) effects on the establishment of glycinergic and GABAergic transmissions in mouse spinal neurons were examined…”
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Presence of ethanol‐sensitive glycine receptors in medium spiny neurons in the mouse nucleus accumbens by Förstera, B., Muñoz, B., Lobo, M. K., Chandra, R., Lovinger, D. M., Aguayo, L. G.

“…Key points The nucleus accumbens (nAc) is involved in addiction‐related behaviour caused by several drugs of abuse, including alcohol. Glycine receptors…”
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Role of membrane GM1 on early neuronal membrane actions of Aβ during onset of Alzheimer's disease by Fernández-Pérez, E.J., Sepúlveda, F.J., Peoples, R., Aguayo, L.G.

“…The ability of beta-amyloid peptide (Aβ) to disrupt the plasma membrane through formation of pores and membrane breakage has been previously described…”
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Changes in neuronal excitability and synaptic transmission in nucleus accumbens in a transgenic Alzheimer’s disease mouse model by Fernández-Pérez, E. J., Gallegos, S., Armijo-Weingart, L., Araya, A., Riffo-Lepe, N. O., Cayuman, F., Aguayo, L. G.

“…Several previous studies showed that hippocampus and cortex are affected in Alzheimer’s disease (AD). However, other brain regions have also been found to be…”
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Anti‐homeostatic synaptic plasticity of glycine receptor function after chronic strychnine in developing cultured mouse spinal neurons by Carrasco, M. A., Castro, P. A., Sepulveda, F. J., Cuevas, M., Tapia, J. C., Izaurieta, P., Zundert, B. van, Aguayo, L. G.

“…In this study, we describe a novel form of anti‐homeostatic plasticity produced after culturing spinal neurons with strychnine, but not bicuculline or…”
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ATP leakage induces P2XR activation and contributes to acute synaptic excitotoxicity induced by soluble oligomers of β-amyloid peptide in hippocampal neurons by Sáez-Orellana, F., Godoy, P.A., Bastidas, C.Y., Silva-Grecchi, T., Guzmán, L., Aguayo, L.G., Fuentealba, J.

“…Recent studies suggest that the toxic effects of Aβ can be attributed to its capability to insert in membranes and form pore-like structures, which are…”
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Rapamycin protects against Aβ-induced synaptotoxicity by increasing presynaptic activity in hippocampal neurons by Ramírez, A.E., Pacheco, C.R., Aguayo, L.G., Opazo, C.M.

“…The mammalian target of rapamycin (mTOR) is involved in the regulation of learning and memory. Recently, rapamycin has been shown to be neuroprotective in…”
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Allosteric modulation of retinal GABA receptors by ascorbic acid by Calero, Cecilia I, Vickers, Evan, Moraga Cid, Gustavo, Aguayo, Luis G, von Gersdorff, Henrique, Calvo, Daniel J

“…Ionotropic GABA receptors (GABA(A) and GABA(C)) belong to the Cys-loop receptor family of ligand-gated ion channels. GABA(C) receptors are highly expressed in…”
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An extracellular mechanism that can explain the neurotoxic effects of α-synuclein aggregates in the brain by Pacheco, C, Aguayo, L G, Opazo, C

“…Neurodegenerative diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD), and Dementia with Lewy bodies (DLB), display an accumulation of…”
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Potentiation of the glycine-activated Cl- current by ethanol in cultured mouse spinal neurons by Aguayo, L G, Tapia, J C, Pancetti, F C

“…Ethanol (1-200 mM), a potent depressor of respiration and motor activity, potentiated the inhibitory Cl- current activated by glycine in 80% of the cultured…”
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Dopamine inhibits a sustained calcium current through activation of alpha adrenergic receptors and a GTP-binding protein in adult rat sympathetic neurons by Aguayo, L G, Grossie, J

“…Although it is suspected that dopamine (DA) inhibits a Ca++ current in sympathetic neurons, the receptor and the Ca++ channel type involved are still unknown…”
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Effects of nerve growth factor on TTX- and capsaicin-sensitivity in adult rat sensory neurons by Aguayo, L G, White, G

“…We have investigated the effects of nerve growth factor (NGF, 2.5 ng/ml for 1-2 weeks) on enriched adult rat dorsal root ganglion (DRG) neurons maintained in…”
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Post-natal development of K+ currents studied in isolated rat pineal cells by Aguayo, L G

“…1. The voltage-activated outward currents in diencephalon-derived neuroendocrine pineal cells, dissociated from rats aged 1 day to 3 weeks post-natal, were…”
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Modulation of glycine-activated ion channel function by G-protein beta gamma subunits by Yevenes, GE, Peoples, R W, Tapia, J C, Parodi, J, Soto, X, Olate, J, Aguayo, L G

“…Glycine receptors (GlyRs), together with GABA sub(A) and nicotinic acetylcholine (ACh) receptors, form part of the ligand-activated ion channel superfamily and…”
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Characterization of membrane currents in dissociated adult rat pineal cells by Aguayo, L G, Weight, F F

“…1. Membrane currents, particularly the outward components, were studied in pineal cells acutely dissociated from adult rats using the whole-cell variant of the…”
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Ethanol affects the function of a neurotransmitter receptor protein without altering the membrane lipid phase by Tapia, Juan C, Aguilar, Luis F, Sotomayor, Carlos P, Aguayo, Luis G

“…Using patch-clamp and fluorescence techniques we found that ethanol (10–200 mM) potentiated strychnine-sensitive glycine receptors without having detectable…”
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Differential effects of GABAergic ligands in mouse and rat hippocampal neurons by Aguayo, L G, Pancetti, F C, Klein, R L, Harris, R A

“…Previous electrophysiological studies suggested that GABAA receptors in rat hippocampal neurons might be less sensitive to ethanol than mouse neurons…”
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