Search Results - "Aguado, Jacqueline"

NYX-2925 Is a Novel N -Methyl-d-Aspartate Receptor Modulator that Induces Rapid and Long-Lasting Analgesia in Rat Models of Neuropathic Pain by Ghoreishi-Haack, Nayereh, Priebe, Jessica M, Aguado, Jacqueline D, Colechio, Elizabeth M, Burgdorf, Jeffrey S, Bowers, M Scott, Cearley, Cassia N, Khan, M Amin, Moskal, Joseph R

“…NYX-2925 [(2S,3R)-3-hydroxy-2-((R)-5-isobutyryl-1-oxo-2,5-diazaspiro[3.4]octan-2-yl)butanamide] is a novel -methyl-d-aspartate (NMDA) receptor modulator that…”
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999 The PTPN2/N1 small molecule inhibitor ABBV-CLS-484 promotes NK cell activity driving primary tumor regression and preventing metastasis by Patel, Chirag, McGuire, Kathleen A, Ebrahimi-Nik, Hakimeh, Sun, Meng, Liu, Yue, Klinge, Kelly, Aguado, Jacqueline, Muscato, Audrey J, Tiwari, Payal, Avila-Monge, Omar, Colvin, Kayla J, Olander, Kira, Halliwill, Kyle, Klahn, Joseph, Schutte, Alexander, Paddock, Marcia N, Powell, Jonathan, Hamel, Keith M, Frost, Jennifer M, Yates, Kathleen B, Kym, Philip R, Manguso, Robert T, Baumgartner, Christina K

“…BackgroundThe tyrosine phosphatases PTPN2 and PTPN1 negatively regulate several signaling pathways in immune and tumor cells. We previously demonstrated that…”
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1403-A PTPN2/N1 inhibitor ABBV-CLS-484 unleashes potent anti-tumor immunity by Ebrahimi-Nik, Hakimeh, Baumgartner, Christina K, Iracheta-Vellve, Arvin, Hamel, Keith M, Olander, Kira, Davis, Thomas GR, McGuire, Kathleen A, Halvorsen, Geoff T, Avila, Omar I, Patel, Chirag, Kim, Sarah, Kammula, Ashwin V, Muscato, Audrey J, Halliwill, Kyle, Geda, Prasanthi, Klinge, Kelly, Xiong, Zhaoming, Duggan, Ryan, Mu, Liang, Yeary, Mitchell D, Patti, James C, Balon, Tyler M, Mathew, Rebecca, Backus, Carey, Kennedy, Domenick, Chen, Angeline, Longenecker, Kenton, Klahn, Joseph, Hrusch, Cara, Krishnan, Navasona, Hutchins, Charles W, Aguado, Jacqueline, Bulic, Marinka, Tiwari, Payal, Colvin, Kayla J, Chuong, Cun Lan, Kohnle, Ian C, Rees, Matthew G, Boghossian, Andrew, Ronan, Melissa, Roth, Jennifer A, Wu, Meng-Ju, Sen, Debattama R, Griffin, Gabriel K, El-Bardeesy, Nabeel, Trusk, Patricia, Sun, Meng, Liu, Yue, Decker, Joshua H, Yang, Yi, Fossey, Stacey, Qiu, Wei, Sun, Qi, Paddock, Marcia N, Farney, Elliot P, Beauregard, Clay, Frost, Jennifer M, Yates, Kathleen B, Kym, Philip R, Manguso, Robert T

“…BackgroundImmune checkpoint blockade is effective for a subset of patients across many cancers, but most patients are refractory to current immunotherapies and…”
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