Search Results - "Agu, Chukwuma"

Common genetic variation drives molecular heterogeneity in human iPSCs by Kilpinen, Helena, Goncalves, Angela, Leha, Andreas, Afzal, Vackar, Alasoo, Kaur, Ashford, Sofie, Bala, Sendu, Bensaddek, Dalila, Casale, Francesco Paolo, Culley, Oliver J., Danecek, Petr, Faulconbridge, Adam, Harrison, Peter W., Kathuria, Annie, McCarthy, Davis, McCarthy, Shane A., Meleckyte, Ruta, Memari, Yasin, Moens, Nathalie, Soares, Filipa, Mann, Alice, Streeter, Ian, Agu, Chukwuma A., Alderton, Alex, Nelson, Rachel, Harper, Sarah, Patel, Minal, White, Alistair, Patel, Sharad R., Clarke, Laura, Halai, Reena, Kirton, Christopher M., Kolb-Kokocinski, Anja, Beales, Philip, Birney, Ewan, Danovi, Davide, Lamond, Angus I., Ouwehand, Willem H., Vallier, Ludovic, Watt, Fiona M., Durbin, Richard, Stegle, Oliver, Gaffney, Daniel J.

“…Technology utilizing human induced pluripotent stem cells (iPS cells) has enormous potential to provide improved cellular models of human disease. However,…”
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Loss of IL-10 signaling in macrophages limits bacterial killing driven by prostaglandin E2 by Mukhopadhyay, Subhankar, Heinz, Eva, Porreca, Immacolata, Alasoo, Kaur, Yeung, Amy, Yang, Huei-Ting, Schwerd, Tobias, Forbester, Jessica L, Hale, Christine, Agu, Chukwuma A, Choi, Yoon Ha, Rodrigues, Julia, Capitani, Melania, Jostins-Dean, Luke, Thomas, David C, Travis, Simon, Gaffney, Daniel, Skarnes, William C, Thomson, Nicholas, Uhlig, Holm H, Dougan, Gordon, Powrie, Fiona

“…Loss of IL-10 signaling in macrophages (Mφs) leads to inflammatory bowel disease (IBD). Induced pluripotent stem cells (iPSCs) were generated from an…”
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Human blood vessel organoids as a model of diabetic vasculopathy by Wimmer, Reiner A., Leopoldi, Alexandra, Aichinger, Martin, Wick, Nikolaus, Hantusch, Brigitte, Novatchkova, Maria, Taubenschmid, Jasmin, Hämmerle, Monika, Esk, Christopher, Bagley, Joshua A., Lindenhofer, Dominik, Chen, Guibin, Boehm, Manfred, Agu, Chukwuma A., Yang, Fengtang, Fu, Beiyuan, Zuber, Johannes, Knoblich, Juergen A., Kerjaschki, Dontscho, Penninger, Josef M.

“…The increasing prevalence of diabetes has resulted in a global epidemic 1 . Diabetes is a major cause of blindness, kidney failure, heart attacks, stroke and…”
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Successful Generation of Human Induced Pluripotent Stem Cell Lines from Blood Samples Held at Room Temperature for up to 48 hr by Agu, Chukwuma A., Soares, Filipa A.C., Alderton, Alex, Patel, Minal, Ansari, Rizwan, Patel, Sharad, Forrest, Sally, Yang, Fengtang, Lineham, Jonathan, Vallier, Ludovic, Kirton, Christopher M.

“…The collection sites of human primary tissue samples and the receiving laboratories, where the human induced pluripotent stem cells (hIPSCs) are derived, are…”
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Population-scale proteome variation in human induced pluripotent stem cells by Mirauta, Bogdan Andrei, Seaton, Daniel D, Bensaddek, Dalila, Brenes, Alejandro, Bonder, Marc Jan, Kilpinen, Helena, Stegle, Oliver, Lamond, Angus I

“…Human disease phenotypes are driven primarily by alterations in protein expression and/or function. To date, relatively little is known about the variability…”
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Novel stem cell technologies are powerful tools to understand the impact of human factors on Plasmodium falciparum malaria by Pance, Alena, Ng, Bee L, Mwikali, Kioko, Koutsourakis, Manousos, Agu, Chukwuma, Rouhani, Foad J, Montandon, Ruddy, Law, Frances, Ponstingl, Hannes, Rayner, Julian C

“…parasites have a complex life cycle, but the most clinically relevant stage of the disease is the invasion of erythrocytes and the proliferation of the…”
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Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy by Stephen, Joshi, Nampoothiri, Sheela, Banerjee, Aditi, Tolman, Nathanial J., Penninger, Josef Martin, Elling, Ullrich, Agu, Chukwuma A., Burke, John D., Devadathan, Kalpana, Kannan, Rajesh, Huang, Yan, Steinbach, Peter J., Martinis, Susan A., Gahl, William A., Malicdan, May Christine V.

“…Progressive microcephaly and neurodegeneration are genetically heterogenous conditions, largely associated with genes that are essential for the survival of…”
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Toxin Kid uncouples DNA replication and cell division to enforce retention of plasmid R1 in Escherichia coli cells by Pimentel, Belén, Nair, Radhika, Bermejo-Rodríguez, Camino, Preston, Mark A., Agu, Chukwuma A., Wang, Xindan, Bernal, Juan A., Sherratt, David J., de la Cueva-Méndez, Guillermo

“…Worldwide dissemination of antibiotic resistance in bacteria is facilitated by plasmids that encode postsegregational killing (PSK) systems. These produce a…”
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A reversible haploid mouse embryonic stem cell biobank resource for functional genomics by Elling, Ulrich, Wimmer, Reiner A., Leibbrandt, Andreas, Burkard, Thomas, Michlits, Georg, Leopoldi, Alexandra, Micheler, Thomas, Abdeen, Dana, Zhuk, Sergei, Aspalter, Irene M., Handl, Cornelia, Liebergesell, Julia, Hubmann, Maria, Husa, Anna-Maria, Kinzer, Manuela, Schuller, Nicole, Wetzel, Ellen, van de Loo, Nina, Martinez, Jorge Arturo Zepeda, Estoppey, David, Riedl, Ralph, Yang, Fengtang, Fu, Beiyuan, Dechat, Thomas, Ivics, Zoltán, Agu, Chukwuma A., Bell, Oliver, Blaas, Dieter, Gerhardt, Holger, Hoepfner, Dominic, Stark, Alexander, Penninger, Josef M.

“…The Haplobank contains over 100,000 individually reversibly mutagenized, barcoded, mouse embryonic cell lines; proof-of-principle experiments were used to…”
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Induction of Neural Crest Stem Cells From Bardet-Biedl Syndrome Patient Derived hiPSCs by Barrell, William B, Griffin, John N, Harvey, Jessica-Lily, Danovi, Davide, Beales, Philip, Grigoriadis, Agamemnon E, Liu, Karen J

“…Neural crest cells arise in the embryo from the neural plate border and migrate throughout the body, giving rise to many different tissue types such as bones…”
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M1623 Differential Expression of iL10r2, STAT1 and STAT3 in Colorectal Cancer by Movadat, Oliver, Gruber, Sabine G, Agu, Chukwuma A, Marian, Brigitte, Wrba, Friedrich, Gasche, Christoph

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Bacteriophage-encoded toxins: the λ-holin protein causes caspase-independent non-apoptotic cell death of eukaryotic cells by Agu, Chukwuma A, Klein, Reinhard, Lengler, Johannes, Schilcher, Franz, Gregor, Wolfgang, Peterbauer, Thomas, Bläsi, Udo, Salmons, Brian, Günzburg, Walter H, Hohenadl, Christine

“…The bacteriophage-encoded holin proteins are known to promote bacterial cell lysis by forming lesions within the cytoplasmic membrane. Recently, we have shown…”
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Mergers and Acquisitions: The Nigerian Banking Consolidation Program by Agu, Chukwuma, Olajide, Damilola, Ikenwilo, Divine, Orji, Anthony

“…This paper examines the determinants of the exit behaviour of banks in the Nigerian consolidation program during July 2004 and December 2005. We conceptualise…”
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The cytotoxic activity of the bacteriophage λ-holin protein reduces tumour growth rates in mammary cancer cell xenograft models by Agu, Chukwuma A., Klein, Reinhard, Schwab, Sonja, König-Schuster, Marielle, Kodajova, Petra, Ausserlechner, Michael, Binishofer, Bernhard, Bläsi, Udo, Salmons, Brian, Günzburg, Walter H., Hohenadl, Christine

“…Background The potential use of gene therapy for cancer treatment is being intensively studied. One approach utilises the expression of genes encoding…”
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Analysis of Migration, Regional Characteristics, and Socioeconomic Outcomes in Developing Economies: Empirical Evidence from Nigeria by Orji, Anthony, Agu, Chukwuma

“…Highly skilled migrants from Nigeria and other developing countries are becoming more attractive resources for industrial countries, as these countries…”
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Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression by Cuomo, Anna S. E., Seaton, Daniel D., McCarthy, Davis J., Martinez, Iker, Bonder, Marc Jan, Garcia-Bernardo, Jose, Amatya, Shradha, Madrigal, Pedro, Isaacson, Abigail, Buettner, Florian, Knights, Andrew, Natarajan, Kedar Nath, Vallier, Ludovic, Marioni, John C., Chhatriwala, Mariya, Stegle, Oliver

“…Recent developments in stem cell biology have enabled the study of cell fate decisions in early human development that are impossible to study in vivo…”
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Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes by White, Jacqueline K., Gerdin, Anna-Karin, Karp, Natasha A., Ryder, Ed, Bussell, James N., Salisbury, Jennifer, Clare, Simon, Ingham, Neil J., Podrini, Christine, Houghton, Richard, Estabel, Jeanne, Bottomley, Joanna R., Melvin, David G., Sunter, David, Barnes, Caroline, Cambridge, Emma, Carragher, Damian, Chana, Prabhjoat, Clarke, Kay, Igosheva, Natalia, Ismail, Ozama, Jackson, Hannah, Kane, Leanne, Lacey, Rosalind, Lucas, Mark, McGill, Katherine, McIntyre, Rebecca E., Messager, Sophie, Mottram, Lynda, Mulderrig, Lee, Pearson, Selina, Roberson, Laura-Anne, Salsbury, Grace, Sanger, Daniel, Shannon, Carl, Thompson, Paul C., Tuck, Elizabeth, Bushell, Wendy, Cook, Ross, Dalvi, Priya, Gleeson, Diane, Habib, Bishoy, Hardy, Matt, Miklejewska, Evelina, Price, Stacey, Sethi, Debarati, von Schiller, Dominique, Vyas, Sapna, West, Anthony P., Evans, Arthur, Holroyd, Simon, Iyer, Vivek, Lewis, Morag, Oakley, Darren, Richardson, David, Smedley, Damian, Agu, Chukwuma, Bryant, Jackie, Delaney, Liz, Gueorguieva, Nadia I., Tharagonnet, Helen, Townsend, Anne J., Biggs, Daniel, Collinson, Adam, Dumeau, Charles-Etienne, Grau, Evelyn, Harrison, Sarah, Ingle, Catherine E., Kundi, Helen, Madich, Alla, Mayhew, Danielle, Metcalf, Tom, Pass, Johanna, Reynolds, Helen, Sinclair, Caroline, Wardle-Jones, Hannah, Woods, Michael, Alexander, Liam, Brown, Terry, Flack, Francesca, Griggs, Nicola, McDermott, Jordan, Rogerson, Claire, White, Gemma, Zielezinski, Pawel, DiTommaso, Tia, Edwards, Andrew, Mahajan, Mary Ann, Yalcin, Binnaz, Tannahill, David, Logan, Darren W., MacArthur, Daniel G., Flint, Jonathan, Mahajan, Vinit B., Smyth, Ian, Watt, Fiona M., Skarnes, William C., Dougan, Gordon, Adams, David J., Bradley, Allan

“…Mutations in whole organisms are powerful ways of interrogating gene function in a realistic context. We describe a program, the Sanger Institute Mouse…”
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Cardelino: computational integration of somatic clonal substructure and single-cell transcriptomes by McCarthy, Davis J., Rostom, Raghd, Huang, Yuanhua, Kunz, Daniel J., Danecek, Petr, Bonder, Marc Jan, Hagai, Tzachi, Lyu, Ruqian, Wang, Wenyi, Gaffney, Daniel J., Simons, Benjamin D., Stegle, Oliver, Teichmann, Sarah A.

“…Bulk and single-cell DNA sequencing has enabled reconstructing clonal substructures of somatic tissues from frequency and cooccurrence patterns of somatic…”
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A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage by Zou, Xueqing, Koh, Gene Ching Chiek, Nanda, Arjun Scott, Degasperi, Andrea, Urgo, Katie, Roumeliotis, Theodoros I, Agu, Chukwuma A, Badja, Cherif, Momen, Sophie, Young, Jamie, Amarante, Tauanne Dias, Side, Lucy, Brice, Glen, Perez-Alonso, Vanesa, Rueda, Daniel, Gomez, Celine, Bushell, Wendy, Harris, Rebecca, Choudhary, Jyoti S, Jiricny, Josef, Skarnes, William C, Nik-Zainal, Serena

“…Mutational signatures are imprints of pathophysiological processes arising through tumorigenesis. We generated isogenic CRISPR-Cas9 knockouts (Δ) of 43 genes…”
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Abstract 4887: Direct mutational consequences of CRISPR-cas9 gene-edited DNA repair genes by Zou, Xueqing, Koh, Gene, Nanda, Scott, Degasperi, Andrea, Urgo, Katie, Bushell, Wendy, Agu, Chukwuma, Perez-Alonso, Vanesa, Rueda, Daniel, Foreman, Julia, Harris, Rebecca, Jiricny, Josef, Skarnes, Bill, Nik-Zainal, Serena

“…Abstract Cancer whole-genome sequencing has revealed characteristic mutational signatures associated with defective DNA repair that underpin human genetic…”
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