Search Results - "Agranovich, Bella"

Metabolic adaptation to consume butyrate under prolonged resource exhaustion by Katz, Sophia, Grajeda-Iglesias, Claudia, Agranovich, Bella, Ghrayeb, Alia, Abramovich, Ifat, Hilau, Sabrin, Gottlieb, Eyal, Hershberg, Ruth

“…Bacteria must often survive following the exhaustion of their external growth resources. Fitting with this need, many bacterial species that cannot sporulate,…”
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Failure to mate enhances investment in behaviors that may promote mating reward and impairs the ability to cope with stressors via a subpopulation of Neuropeptide F receptor neurons by Ryvkin, Julia, Omesi, Liora, Kim, Yong-Kyu, Levi, Mali, Pozeilov, Hadar, Barak-Buchris, Lital, Agranovich, Bella, Abramovich, Ifat, Gottlieb, Eyal, Jacob, Avi, Nässel, Dick R, Heberlein, Ulrike, Shohat-Ophir, Galit

“…Living in dynamic environments such as the social domain, where interaction with others determines the reproductive success of individuals, requires the…”
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Bioenergetic and Metabolic Impairments in Induced Pluripotent Stem Cell-Derived Cardiomyocytes Generated from Duchenne Muscular Dystrophy Patients by Willi, Lubna, Abramovich, Ifat, Fernandez-Garcia, Jonatan, Agranovich, Bella, Shulman, Margarita, Milman, Helena, Baskin, Polina, Eisen, Binyamin, Michele, Daniel E., Arad, Michael, Binah, Ofer, Gottlieb, Eyal

“…Duchenne muscular dystrophy (DMD) is caused by mutations in the dystrophin gene and dilated cardiomyopathy (DCM) is a major cause of morbidity and mortality in…”
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Diet-omics in the Study of Urban and Rural Crohn disease Evolution (SOURCE) cohort by Braun, Tzipi, Feng, Rui, Amir, Amnon, Levhar, Nina, Shacham, Hila, Mao, Ren, Hadar, Rotem, Toren, Itamar, Algavi, Yadid, Abu-Saad, Kathleen, Zhuo, Shuoyu, Efroni, Gilat, Malik, Alona, Picard, Orit, Yavzori, Miri, Agranovich, Bella, Liu, Ta-Chiang, Stappenbeck, Thaddeus S., Denson, Lee, Kalter-Leibovici, Ofra, Gottlieb, Eyal, Borenstein, Elhanan, Elinav, Eran, Chen, Minhu, Ben-Horin, Shomron, Haberman, Yael

“…Crohn disease (CD) burden has increased with globalization/urbanization, and the rapid rise is attributed to environmental changes rather than genetic drift…”
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Kidney Proximal Tubule GLUT2-More than Meets the Eye by Ahmad, Majdoleen, Abramovich, Ifat, Agranovich, Bella, Nemirovski, Alina, Gottlieb, Eyal, Hinden, Liad, Tam, Joseph

“…Tubulopathy plays a central role in the pathophysiology of diabetic kidney disease (DKD). Under diabetic conditions, the kidney proximal tubule cells (KPTCs)…”
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Update on metabolomic findings in COPD patients by Gea, Joaquim, Enríquez-Rodríguez, César J, Agranovich, Bella, Pascual-Guardia, Sergi

“…COPD is a heterogeneous disorder that shows diverse clinical presentations (phenotypes and "treatable traits") and biological mechanisms (endotypes). This…”
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Mapping the metabolic reprogramming induced by sodium-glucose cotransporter 2 inhibition by Kogot-Levin, Aviram, Riahi, Yael, Abramovich, Ifat, Mosenzon, Ofri, Agranovich, Bella, Kadosh, Liat, Ben-Haroush Schyr, Rachel, Kleiman, Doron, Hinden, Liad, Cerasi, Erol, Ben-Zvi, Danny, Bernal-Mizrachi, Ernesto, Tam, Joseph, Gottlieb, Eyal, Leibowitz, Gil

“…Diabetes is associated with increased risk for kidney disease, heart failure, and mortality. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) prevent these…”
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Differential effects of bariatric surgery and caloric restriction on hepatic one-carbon and fatty acid metabolism by Haran, Arnon, Bergel, Michael, Kleiman, Doron, Hefetz, Liron, Israeli, Hadar, Weksler-Zangen, Sarah, Agranovich, Bella, Abramovich, Ifat, Ben-Haroush Schyr, Rachel, Gottlieb, Eyal, Ben-Zvi, Danny

“…Weight loss interventions, including dietary changes, pharmacotherapy, or bariatric surgery, prevent many of the adverse consequences of obesity, and may also…”
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A metabolic switch to the pentose-phosphate pathway induces radiation resistance in pancreatic cancer by Shimoni-Sebag, Ariel, Abramovich, Ifat, Agranovich, Bella, Massri, Rami, Stossel, Chani, Atias, Dikla, Raites-Gurevich, Maria, Yizhak, Keren, Golan, Talia, Gottlieb, Eyal, Lawrence, Yaacov Richard

“…[Display omitted] •Novel model of radioresistance identified in pancreatic cancer.•Radioresistant PDAC cells display metabolic reprogramming.•Elevated…”
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Impairment of serine transport across the blood-brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction by Radzishevsky, Inna, Odeh, Maali, Bodner, Oded, Zubedat, Salman, Shaulov, Lihi, Litvak, Maxim, Esaki, Kayoko, Yoshikawa, Takeo, Agranovich, Bella, Li, Wen-Hong, Radzishevsky, Alex, Gottlieb, Eyal, Avital, Avi, Wolosker, Herman

“…Brain L-serine is critical for neurodevelopment and is thought to be synthesized solely from glucose. In contrast, we found that the influx of L-serine across…”
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Tu1754 MODELS FOR PREDICTING CROHN DISEASE (CD) EXACERBATION USING SERUM AND FECAL METABOLOMICS by Levhar, Nina, Hadar, Rotem, Braun, Tzipi, Efroni, Gilat, Naamneh, Raneen, Agranovich, Bella, Asher, Adi Talan, Selinger, Limor, Picard, Orit, Lahat, Adi, Eliakim, Rami, Kopylov, Uri, Ben-Horin, Shomron, Amir, Amnon, Haberman, Yael

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Endogenous histidine peptides are physiological antioxidants that prevent oligodendrocyte cell death and myelin loss in vivo by Sajrawi, Clara, Odeh, Maali, Tiwari, Akshay K, Agranovich, Bella, Abramovich, Ifat, Zubedat, Salman, Saar, Galit, Shaulov, Lihi, Avital, Avi, Reznik, Dan, Benhar, Moran, Radzishevsky, Inna, Engelender, Simone, Wolosker, Herman

“…Histidine dipeptides (HDs) are synthesized in brain oligodendrocytes by carnosine synthase (carns1), but their role is unknown. Using metabolomics and in vivo…”
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Glycine ameliorates paracetamol-induced liver injury in non-alcoholic fatty liver disease by supporting glutathione biosynthesis by Ghrayeb, Alia, Drucker, Shani, Agranovich, Bella, Peled, Daniel, Rom, Oren, Abramovich, Ifat, Fernandes, Sara, Weissman, Natan, Garcia, Jonatan Fernandez, Traylor, James, Eugene, Chen, Gottlieb, Eyal, Mor, Inbal

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Hyperglucagonaemia in diabetes: altered amino acid metabolism triggers mTORC1 activation, which drives glucagon production by Riahi, Yael, Kogot-Levin, Aviram, Kadosh, Liat, Agranovich, Bella, Malka, Assaf, Assa, Michael, Piran, Ron, Avrahami, Dana, Glaser, Benjamin, Gottlieb, Eyal, Jackson, Fields, Cerasi, Erol, Bernal-Mizrachi, Ernesto, Helman, Aharon, Leibowitz, Gil

“…Aim/hypothesis Hyperglycaemia is associated with alpha cell dysfunction, leading to dysregulated glucagon secretion in type 1 and type 2 diabetes; however, the…”
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Failure to mate enhances investment in behaviors that may promote mating reward and impairs the ability to cope with stressors via a subpopulation of Neuropeptide F receptor neurons by Julia Ryvkin, Liora Omesi, Yong-Kyu Kim, Mali Levi, Hadar Pozeilov, Lital Barak-Buchris, Bella Agranovich, Ifat Abramovich, Eyal Gottlieb, Avi Jacob, Dick R. Nässel, Ulrike Heberlein, Galit Shohat-Ophir

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Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD by Ghrayeb, Alia, Finney, Alexandra C, Agranovich, Bella, Peled, Daniel, Anand, Sumit Kumar, McKinney, M Peyton, Sarji, Mahasen, Yang, Dongshan, Weissman, Natan, Drucker, Shani, Fernandes, Sara Isabel, Fernández-García, Jonatan, Mahan, Kyle, Abassi, Zaid, Tan, Lin, Lorenzi, Philip L, Traylor, James, Zhang, Jifeng, Abramovich, Ifat, Chen, Y Eugene, Rom, Oren, Mor, Inbal, Gottlieb, Eyal

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) affects one-third of the global population. Understanding the metabolic pathways involved can…”
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Arginine depletion attenuates renal cystogenesis in tuberous sclerosis complex model by Amleh, Athar, Chen, Hadass Pri, Watad, Lana, Abramovich, Ifat, Agranovich, Bella, Gottlieb, Eyal, Ben-Dov, Iddo Z., Nechama, Morris, Volovelsky, Oded

“…Cystic kidney disease is a leading cause of morbidity in patients with tuberous sclerosis complex (TSC). We characterize the misregulated metabolic pathways…”
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Abstract 2411: The pentose-phosphate pathway induces pancreatic cancer radioresistance, a preclinical study with clinical validation by Shimoni-Sebag, Ariel, Abramovich, Ifat, Agranovich, Bella, Sirovsky, Yaarit, Stossel, Chani, Atias, Dikla, Raitses-Gurevich, Maria, Glick-Gorman, Yulia, Margalit, Ofer, Regev, David, Tal, Rotem, Tirosh, Itay, Golan, Talia, Yizhak, Keren, Gottlieb, Eyal, Lawrence, Yaacov R.

“…Purpose: Pancreatic ductal adenocarcinoma (PDAC) is remarkably resistant to standard modalities, including radiotherapy (RT). The mechanisms of radiation…”
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