Search Results - "Agoulnik, Irina U"

Editorial: Sphingolipid metabolism and cancer by Ivanova, Margarita M., Agoulnik, Irina U., LLeonart, Matilde E.

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Deletion of inositol polyphosphate 4-phosphatase type-II B affects spermatogenesis in mice by Ceyhan, Yasemin, Zhang, Manqi, Guo, Jingtao, Sandoval, Carlos G, Vacher, Jean, Kaftanovskaya, Elena M, Agoulnik, Alexander I, Agoulnik, Irina U

“…Inositol polyphosphate-4-phosphatase type II (INPP4B) is a dual-specificity phosphatase that acts as a tumor suppressor in multiple cancers. INPP4B…”
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Decreased Expression and Androgen Regulation of the Tumor Suppressor Gene INPP4B in Prostate Cancer by HODGSON, Myles C, SHAO, Long-Jiang, FROLOV, Anna, RILE LI, PETERSON, Leif E, AYALA, Gustavo, ITTMANN, Michael M, WEIGEL, Nancy L, AGOULNIK, Irina U

“…Patients with metastatic prostate cancer who undergo androgen-ablation therapy invariably relapse and develop incurable castration-resistant disease…”
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Androgen receptor action in hormone-dependent and recurrent prostate cancer by Agoulnik, Irina U., Weigel, Nancy L.

“…The importance of androgens and androgen receptors (AR) in primary prostate cancer is well established. Metastatic disease is usually treated with some form of…”
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Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1 by Xiao, Jingbo, Huang, Zaohua, Chen, Catherine Z., Agoulnik, Irina U., Southall, Noel, Hu, Xin, Jones, Raisa E., Ferrer, Marc, Zheng, Wei, Agoulnik, Alexander I., Marugan, Juan J.

“…The anti-fibrotic, vasodilatory and pro-angiogenic therapeutic properties of recombinant relaxin peptide hormone have been investigated in several diseases,…”
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Coactivator selective regulation of androgen receptor activity by Agoulnik, Irina U., Weigel, Nancy L.

“…The androgen receptor (AR) is a ligand activated nuclear receptor, which regulates transcription and stimulates growth of androgen dependent prostate cancer…”
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Role of SRC-1 in the promotion of prostate cancer cell growth and tumor progression by AGOULNIK, Irina U, VAID, Ajula, BINGMAN, William E, ERDEME, Halime, FROLOV, Anna, SMITH, Carolyn L, AYALA, Gustavo, ITTMANN, Michael M, WEIGEL, Nancy L

“…Prostate cancer is initially androgen dependent and there is evidence that androgen receptor continues to play a role in androgen-independent prostate cancer…”
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Relaxin Promotes Prostate Cancer Progression by SHU FENG, AGOULNIK, Irina U, BOGATCHEVA, Natalia V, KAMAT, Aparna A, KWABI-ADDO, Bernard, LI, Rile, AYALA, Gustavo, ITTMANN, Michael M, AGOULNIK, Alexander I

“…Purpose: To understand the role of relaxin peptide in prostate cancer, we analyzed the expression of relaxin and its receptor in human prostate cancer samples,…”
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Base excision repair of chemotherapeutically-induced alkylated DNA damage predominantly causes contractions of expanded GAA repeats associated with Friedreich's ataxia by Lai, Yanhao, Beaver, Jill M, Lorente, Karla, Melo, Jonathan, Ramjagsingh, Shyama, Agoulnik, Irina U, Zhang, Zunzhen, Liu, Yuan

“…Expansion of GAA·TTC repeats within the first intron of the frataxin gene is the cause of Friedreich's ataxia (FRDA), an autosomal recessive neurodegenerative…”
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INPP4B protects from metabolic syndrome and associated disorders by Zhang, Manqi, Ceyhan, Yasemin, Kaftanovskaya, Elena M., Vasquez, Judy L., Vacher, Jean, Knop, Filip K., Nathanson, Lubov, Agoulnik, Alexander I., Ittmann, Michael M., Agoulnik, Irina U.

“…A high fat diet and obesity have been linked to the development of metabolic dysfunction and the promotion of multiple cancers. The causative cellular signals…”
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Suppression of relaxin receptor RXFP1 decreases prostate cancer growth and metastasis by Feng, Shu, Agoulnik, Irina U, Truong, Anne, Li, Zhen, Creighton, Chad J, Kaftanovskaya, Elena M, Pereira, Rhea, Han, Hee Dong, Lopez-Berestein, Gabriel, Klonisch, Thomas, Ittmann, Michael M, Sood, Anil K, Agoulnik, Alexander I

“…Relaxin (RLN) is a small peptide hormone expressed in several cancers of reproductive and endocrine organs. Increased expression of RLN in prostate cancer…”
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Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2 by Esteban-Lopez, Maria, Wilson, Kenneth J., Myhr, Courtney, Kaftanovskaya, Elena M., Henderson, Mark J., Southall, Noel T., Xu, Xin, Wang, Amy, Hu, Xin, Barnaeva, Elena, Ye, Wenjuan, George, Emmett R., Sherrill, John T., Ferrer, Marc, Morello, Roy, Agoulnik, Irina U., Marugan, Juan J., Agoulnik, Alexander I.

“…The relaxin/insulin-like family peptide receptor 2 (RXFP2) belongs to the family of class A G-protein coupled receptors (GPCRs) and it is the only known target…”
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Activation of Relaxin Family Receptor 1 from Different Mammalian Species by Relaxin Peptide and Small-Molecule Agonist ML290 by Huang, Zaohua, Myhr, Courtney, Bathgate, Ross A D, Ho, Brian A, Bueno, Amaya, Hu, Xin, Xiao, Jingbo, Southall, Noel, Barnaeva, Elena, Agoulnik, Irina U, Marugan, Juan J, Ferrer, Marc, Agoulnik, Alexander I

“…Relaxin peptide (RLN), which signals through the relaxin family peptide 1 (RXFP1) GPCR receptor, has shown therapeutic effects in an acute heart failure…”
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Reduced androgen receptor expression accelerates the onset of ERBB2 induced breast tumors in female mice by Hodgson, Myles C, Vanostran, Garrett, Alghamdi, Sarah, Poppiti, Robert J, Agoulnik, Alexander I, Agoulnik, Irina U

“…Androgen receptor (AR) is commonly expressed in both the epithelium of normal mammary glands and in breast cancers. AR expression in breast cancers is…”
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Identification of small-molecule agonists of human relaxin family receptor 1 (RXFP1) by using a homogenous cell-based cAMP assay by Chen, Catherine Z, Southall, Noel, Xiao, Jingbo, Marugan, Juan J, Ferrer, Marc, Hu, Xin, Jones, Raisa E, Feng, Shu, Agoulnik, Irina U, Zheng, Wei, Agoulnik, Alexander I

“…The relaxin hormone is involved in a variety of biological functions, including female reproduction and parturition, as well as regulation of cardiovascular,…”
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Developmental Expression and Gene Regulation of Insulin-like 3 Receptor RXFP2 in Mouse Male Reproductive Organs by Feng, Shu, Bogatcheva, Natalia V, Truong, Anne, Korchin, Borys, Bishop, Colin E, Klonisch, Thomas, Agoulnik, Irina U, Agoulnik, Alexander I

“…The mutations of testicular insulin-like 3 (INSL3) hormone or its receptor RXFP2 cause cryptorchidism in male mice. Here we have examined Rxfp2 gene expression…”
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Target Gene-Specific Regulation of Androgen Receptor Activity by p42/p44 Mitogen-Activated Protein Kinase by Agoulnik, Irina U, Bingman, William E, Nakka, Manjula, Li, Wei, Wang, Qianben, Liu, X. Shirley, Brown, Myles, Weigel, Nancy L

“…Evidence that the androgen receptor (AR) is not only important in androgen-dependent prostate cancer, but also continues to play a role in tumors that become…”
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Synthetic non‐peptide low molecular weight agonists of the relaxin receptor 1 by Agoulnik, Alexander I, Agoulnik, Irina U, Hu, Xin, Marugan, Juan

“…Relaxin is a small heterodimeric peptide hormone of the insulin/relaxin superfamily produced mainly in female and male reproductive organs. It has potent…”
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Expression patterns and the roles of phosphatidylinositol phosphatases in testis by Ceyhan, Yasemin, Zhang, Manqi, Sandoval, Carlos G., Agoulnik, Alexander I., Agoulnik, Irina U.

“…Phosphoinositides (PIs) are relatively rare lipid components of the cellular membranes. Their homeostasis is tightly controlled by specific PI kinases and PI…”
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Engineering a long acting, non-biased relaxin agonist using Protein-in-Protein technology by Agoulnik, Irina U., Kaftanovskaya, Elena M., Myhr, Courtney, Bathgate, Ross A.D., Kocan, Martina, Peng, Yingjie, Lindsay, Ronald M., DiStefano, Peter S., Agoulnik, Alexander I.

“…[Display omitted] The peptide hormone relaxin plays a critical role in tissue remodeling in a variety of tissues through activation of its cognate receptor,…”
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