Search Results - "Agoulnik, Alexander"

Diverse functions of insulin-like 3 peptide by Esteban-Lopez, Maria, Agoulnik, Alexander I

“…Insulin-like 3 peptide (INSL3) is a member of the insulin-like peptide superfamily and is the only known physiological ligand of relaxin family peptide…”
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Expression patterns and the roles of phosphatidylinositol phosphatases in testis by Ceyhan, Yasemin, Zhang, Manqi, Sandoval, Carlos G., Agoulnik, Alexander I., Agoulnik, Irina U.

“…Phosphoinositides (PIs) are relatively rare lipid components of the cellular membranes. Their homeostasis is tightly controlled by specific PI kinases and PI…”
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Relaxin‐like peptides in male reproduction – a human perspective by Ivell, Richard, Agoulnik, Alexander I, Anand‐Ivell, Ravinder

“…The relaxin family of peptide hormones and their cognate GPCRs are becoming physiologically well‐characterized in the cardiovascular system and particularly in…”
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NOTCH1 gain of function in germ cells causes failure of spermatogenesis in male mice by Huang, Zaohua, Rivas, Bryan, Agoulnik, Alexander I

“…NOTCH1 is a member of the NOTCH receptor family, a group of single-pass trans-membrane receptors. NOTCH signaling is highly conserved in evolution and mediates…”
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GLI3 resides at the intersection of hedgehog and androgen action to promote male sex differentiation by Kothandapani, Anbarasi, Lewis, Samantha R, Noel, Jessica L, Zacharski, Abbey, Krellwitz, Kyle, Baines, Anna, Winske, Stephanie, Vezina, Chad M, Kaftanovskaya, Elena M, Agoulnik, Alexander I, Merton, Emily M, Cohn, Martin J, Jorgensen, Joan S

“…Urogenital tract abnormalities are among the most common congenital defects in humans. Male urogenital development requires Hedgehog-GLI signaling and…”
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Testicular cancer and cryptorchidism by Ferguson, Lydia, Agoulnik, Alexander I

“…The failure of testicular descent or cryptorchidism is the most common defect in newborn boys. The descent of the testes during development is controlled by…”
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Deletion of inositol polyphosphate 4-phosphatase type-II B affects spermatogenesis in mice by Ceyhan, Yasemin, Zhang, Manqi, Guo, Jingtao, Sandoval, Carlos G, Vacher, Jean, Kaftanovskaya, Elena M, Agoulnik, Alexander I, Agoulnik, Irina U

“…Inositol polyphosphate-4-phosphatase type II (INPP4B) is a dual-specificity phosphatase that acts as a tumor suppressor in multiple cancers. INPP4B…”
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Rethinking dog domestication by integrating genetics, archeology, and biogeography by Larson, Greger, Karlsson, Elinor K., Perri, Angela, Webster, Matthew T., Ho, Simon Y. W., Peters, Joris, Stahl, Peter W., Piper, Philip J., Lingaas, Frode, Fredholm, Merete, Comstock, Kenine E., Modiano, Jaime F., Schelling, Claude, Agoulnik, Alexander I., Leegwater, Peter A., Dobney, Keith, Vigne, Jean-Denis, Vilà, Carles, Andersson, Leif, Lindblad-Toh, Kerstin

“…The dog was the first domesticated animal but it remains uncertain when the domestication process began and whether it occurred just once or multiple times…”
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Synthetic non‐peptide low molecular weight agonists of the relaxin receptor 1 by Agoulnik, Alexander I, Agoulnik, Irina U, Hu, Xin, Marugan, Juan

“…Relaxin is a small heterodimeric peptide hormone of the insulin/relaxin superfamily produced mainly in female and male reproductive organs. It has potent…”
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INSL3 in the muscolo-skeletal system by De Toni, Luca, Agoulnik, Alexander I., Sandri, Marco, Foresta, Carlo, Ferlin, Alberto

“…Bone and skeletal muscle are currently considered a unified functional unit, showing complementary regulation at mechanical, biochemical, paracrine and…”
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Targeting the relaxin/insulin-like family peptide receptor 1 and 2 with small molecule compounds by Ng, Hooi Hooi, Esteban-Lopez, Maria, Agoulnik, Alexander I.

“…The peptide hormone relaxin has beneficial roles in several organs through its action on its cognate G protein-coupled receptor, RXFP1. Relaxin administration…”
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Insulin-Like 3 Signaling Is Important for Testicular Descent but Dispensable for Spermatogenesis and Germ Cell Survival in Adult Mice by ZAOHUA HUANG, RIVAS, Bryan, AGOULNIK, Alexander I

“…Relaxin family peptide receptor 2 (RXFP2) is the cognate receptor of a peptide hormone insulin-like 3 (INSL3). INSL3 is expressed at high levels in both fetal…”
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Genetic ablation of androgen receptor signaling in fetal Leydig cell lineage affects Leydig cell functions in adult testis by Kaftanovskaya, Elena M., Lopez, Carolina, Ferguson, Lydia, Myhr, Courtney, Agoulnik, Alexander I.

“…ABSTRACT It is commonly accepted that androgen‐producing fetal Leydig cells (FLC) are substituted by adult Leydig cells (ALC) during perinatal testis…”
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Engineering a long acting, non-biased relaxin agonist using Protein-in-Protein technology by Agoulnik, Irina U., Kaftanovskaya, Elena M., Myhr, Courtney, Bathgate, Ross A.D., Kocan, Martina, Peng, Yingjie, Lindsay, Ronald M., DiStefano, Peter S., Agoulnik, Alexander I.

“…[Display omitted] The peptide hormone relaxin plays a critical role in tissue remodeling in a variety of tissues through activation of its cognate receptor,…”
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ML290 is a biased allosteric agonist at the relaxin receptor RXFP1 by Kocan, Martina, Sarwar, Mohsin, Ang, Sheng Y., Xiao, Jingbo, Marugan, Juan J., Hossain, Mohammed A., Wang, Chao, Hutchinson, Dana S., Samuel, Chrishan S., Agoulnik, Alexander I., Bathgate, Ross A. D., Summers, Roger J.

“…Activation of the relaxin receptor RXFP1 has been associated with improved survival in acute heart failure. ML290 is a small molecule RXFP1 agonist with simple…”
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Anti-apoptotic and Matrix Remodeling Actions of a Small Molecule Agonist of the Human Relaxin Receptor, ML290 in Mice With Unilateral Ureteral Obstruction by Ng, Hooi Hooi, Soula, Mariluz, Rivas, Bryan, Wilson, Kenneth J., Marugan, Juan J., Agoulnik, Alexander I.

“…Diseases, such as diabetes and hypertension, often lead to chronic kidney failure. The peptide hormone relaxin has been shown to have therapeutic effects in…”
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Protective Role of Testicular Hormone INSL3 From Atrophy and Weakness in Skeletal Muscle by Ferlin, Alberto, De Toni, Luca, Agoulnik, Alexander I, Lunardon, Giorgia, Armani, Andrea, Bortolanza, Sergia, Blaauw, Bert, Sandri, Marco, Foresta, Carlo

“…Androgens are primarily involved in muscle growth, whilst disease-driven muscle wasting is frequently associated with hypogonadism. The Leydig cells of the…”
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The fate of spermatogonial stem cells in the cryptorchid testes of RXFP2 deficient mice by Ferguson, Lydia, How, Javier J, Agoulnik, Alexander I

“…The environmental niche of the spermatogonial stem cell pool is critical to ensure the continued generation of the germ cell population. To study the…”
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Normal fertility in male mice with deletion of β-catenin gene in germ cells by Rivas, Bryan, Huang, Zaohua, Agoulnik, Alexander I.

“…Summary As a dual function protein, β‐catenin affects both cell adhesion and mediates canonical Wnt/β‐catenin cell signaling. β‐Catenin is prominently…”
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Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosis by Kaftanovskaya, Elena M., Ng, Hooi Hooi, Soula, Mariluz, Rivas, Bryan, Myhr, Courtney, Ho, Brian A., Cervantes, Briana A., Shupe, Thomas D., Devarasetty, Mahesh, Hu, Xin, Xu, Xin, Patnaik, Samarjit, Wilson, Kenneth J., Barnaeva, Elena, Ferrer, Marc, Southall, Noel T., Marugan, Juan J., Bishop, Colin E., Agoulnik, Irina U., Agoulnik, Alexander I.

“…Fibrosis is an underlying cause of cirrhosis and hepatic failure resulting in end stage liver disease with limited pharmacological options. The beneficial…”
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