Search Results - "Agosto, Luis M"

Highly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission by Agosto, Luis M, Zhong, Peng, Munro, James, Mothes, Walther

“…HIV-1 cell-to-cell transmission allows for 2-3 orders of magnitude more efficient viral spread than cell-free dissemination. The high local multiplicity of…”
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HIV cell-to-cell transmission: effects on pathogenesis and antiretroviral therapy by Agosto, Luis M, Uchil, Pradeep D, Mothes, Walther

“…Highlights • Cell-to-cell transmission may contribute to pathogenesis seen in HIV-infected individuals. • Effective antiretroviral therapy suppresses both…”
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Cell-to-cell transmission can overcome multiple donor and target cell barriers imposed on cell-free HIV by Zhong, Peng, Agosto, Luis M, Ilinskaya, Anna, Dorjbal, Batsukh, Truong, Rosaline, Derse, David, Uchil, Pradeep D, Heidecker, Gisela, Mothes, Walther

“…Virus transmission can occur either by a cell-free mode through the extracellular space or by cell-to-cell transmission involving direct cell-to-cell contact…”
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Mechanisms of HIV-1 cell-to-cell transmission and the establishment of the latent reservoir by Pedro, Kyle D., Henderson, Andrew J., Agosto, Luis M.

“…•HIV-1 utilizes several forms of cell-to-cell transmission that influence viral dissemination, survival and pathogenesis.•HIV-1 cell-to-cell transmission…”
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Comprehensive mapping of the human cytokine gene regulatory network by Santoso, Clarissa S, Li, Zhaorong, Lal, Sneha, Yuan, Samson, Gan, Kok Ann, Agosto, Luis M, Liu, Xing, Pro, Sebastian Carrasco, Sewell, Jared A, Henderson, Andrew, Atianand, Maninjay K, Fuxman Bass, Juan I

“…Abstract Proper cytokine gene expression is essential in development, homeostasis and immune responses. Studies on the transcriptional control of cytokine…”
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Directly infected resting CD4+T cells can produce HIV Gag without spreading infection in a model of HIV latency by Pace, Matthew J, Graf, Erin H, Agosto, Luis M, Mexas, Angela M, Male, Frances, Brady, Troy, Bushman, Frederic D, O'Doherty, Una

“…Despite the effectiveness of highly active antiretroviral therapy (HAART) in treating individuals infected with HIV, HAART is not a cure. A latent reservoir,…”
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HIV latency and integration site placement in five cell-based models by Sherrill-Mix, Scott, Lewinski, Mary K, Famiglietti, Marylinda, Bosque, Alberto, Malani, Nirav, Ocwieja, Karen E, Berry, Charles C, Looney, David, Shan, Liang, Agosto, Luis M, Pace, Matthew J, Siliciano, Robert F, O'Doherty, Una, Guatelli, John, Planelles, Vicente, Bushman, Frederic D

“…HIV infection can be treated effectively with antiretroviral agents, but the persistence of a latent reservoir of integrated proviruses prevents eradication of…”
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Human Immunodeficiency Virus Integrates Directly into Naïve Resting CD4+ T Cells but Enters Naïve Cells Less Efficiently than Memory Cells by JIHONG DAI, AGOSTO, Luis M, BAYTOP, Clifford, YU, Jianqing J, PACE, Matthew J, LISZEWSKI, Megan K, O'DOHERTY, Una

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The CXCR4-Tropic Human Immunodeficiency Virus Envelope Promotes More-Efficient Gene Delivery to Resting CD4+ T Cells than the Vesicular Stomatitis Virus Glycoprotein G Envelope by Agosto, Luis M, Yu, Jianqing J, Liszewski, Megan K, Baytop, Clifford, Korokhov, Nikolay, Humeau, Laurent M, O'Doherty, Una

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HIV-1-Infected CD4+ T Cells Facilitate Latent Infection of Resting CD4+ T Cells through Cell-Cell Contact by Agosto, Luis M., Herring, Melissa B., Mothes, Walther, Henderson, Andrew J.

“…HIV-1 is transmitted between T cells through the release of cell-free particles and through cell-cell contact. Cell-to-cell transmission is more efficient than…”
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Cell-to-cell transmission of viruses by Zhong, Peng, Agosto, Luis M, Munro, James B, Mothes, Walther

“…[Display omitted] ► Barriers in the cell-free mode of virus transmission can promote virus cell-to-cell transmission. ► Donor and target cell induced…”
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HIV-1 replicates and persists in vaginal epithelial dendritic cells by Pena-Cruz, Victor, Agosto, Luis M, Akiyama, Hisashi, Olson, Alex, Moreau, Yvetane, Larrieux, Jean-Robert, Henderson, Andrew, Gummuluru, Suryaram, Sagar, Manish

“…HIV-1 acquisition occurs most commonly after sexual contact. To establish infection, HIV-1 must infect cells that support high-level replication, namely CD4+ T…”
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Enhanced Human Immunodeficiency Virus-1 Replication in CD4+ T Cells Derived From Individuals With Latent Mycobacterium tuberculosis Infection by He, Xianbao, Eddy, Jared J, Jacobson, Karen R, Henderson, Andrew J, Agosto, Luis M

“…Mycobacterium tuberculosis (Mtb) and human immunodeficiency virus (HIV) coinfection increases mortality, accelerates progression to acquired immune deficiency…”
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HIV integration site distributions in resting and activated CD4+ T cells infected in culture by BRADY, Troy, AGOSTO, Luis M, MALANI, Nirav, BERRY, Charles C, O'DOHERTY, Una, BUSHMAN, Frederic

“…The goal of this study was to investigate whether the location of HIV integration differs in resting versus activated T cells, a feature that could contribute…”
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A functional screen identifies transcriptional networks that regulate HIV-1 and HIV-2 by Pedro, Kyle D., Agosto, Luis M., Sewell, Jared A., Eberenz, Kimberly A., He, Xianbao, Bass, Juan I. Fuxman, Henderson, Andrew J.

“…The molecular networks involved in the regulation of HIV replication, transcription, and latency remain incompletely defined. To expand our understanding of…”
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Virion-Associated Vpr Alleviates a Postintegration Block to HIV-1 Infection of Dendritic Cells by Miller, Caitlin M, Akiyama, Hisashi, Agosto, Luis M, Emery, Ann, Ettinger, Chelsea R, Swanstrom, Ronald I, Henderson, Andrew J, Gummuluru, Suryaram

“…Viral protein R (Vpr) is an HIV-1 accessory protein whose function remains poorly understood. In this report, we sought to determine the requirement of Vpr for…”
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A Subset of CD4/CD8 Double-Negative T Cells Expresses HIV Proteins in Patients on Antiretroviral Therapy by DeMaster, Laura K, Liu, Xiaohe, VanBelzen, D Jake, Trinité, Benjamin, Zheng, Lingjie, Agosto, Luis M, Migueles, Stephen A, Connors, Mark, Sambucetti, Lidia, Levy, David N, Pasternak, Alexander O, O'Doherty, Una

“…A major goal in HIV eradication research is characterizing the reservoir cells that harbor HIV in the presence of antiretroviral therapy (ART), which reseed…”
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HIV-1 integrates into resting CD4+ T cells even at low inoculums as demonstrated with an improved assay for HIV-1 integration by Agosto, Luis M, Yu, Jianqing J, Dai, Jihong, Kaletsky, Rachel, Monie, Daphne, O'Doherty, Una

“…Abstract Human Immunodeficiency Virus Type 1 (HIV-1) establishes a latent reservoir early in infection that is resistant to the host immune response and…”
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Porphyromonas gingivalis -mediated signaling through TLR4 mediates persistent HIV infection of primary macrophages by Agosto, Luis M, Hirnet, Juliane B, Michaels, Daniel H, Shaik-Dasthagirisaheb, Yazdani B, Gibson, Frank C, Viglianti, Gregory, Henderson, Andrew J

“…Abstract Periodontal infections contribute to HIV-associated co-morbidities in the oral cavity and provide a model to interrogate the dysregulation of…”
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Impact of Chromatin on HIV Replication by Agosto, Luis M, Gagne, Matthew, Henderson, Andrew J

“…Chromatin influences Human Immunodeficiency Virus (HIV) integration and replication. This review highlights critical host factors that influence chromatin…”
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