Search Results - "Agostinis, P."

Transplantation and Damage‐Associated Molecular Patterns (DAMPs) by Land, W. G., Agostinis, P., Gasser, S., Garg, A. D., Linkermann, A.

“…Upon solid organ transplantation and during cancer immunotherapy, cellular stress responses result in the release of damage‐associated molecular patterns…”
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PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress by Verfaillie, T, Rubio, N, Garg, A D, Bultynck, G, Rizzuto, R, Decuypere, J-P, Piette, J, Linehan, C, Gupta, S, Samali, A, Agostinis, P

“…Endoplasmic reticulum stress is emerging as an important modulator of different pathologies and as a mechanism contributing to cancer cell death in response to…”
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Danger signalling during cancer cell death: origins, plasticity and regulation by Garg, A D, Martin, S, Golab, J, Agostinis, P

“…Accumulating data indicates that following anti-cancer treatments, cancer cell death can be perceived as immunogenic or tolerogenic by the immune system. The…”
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Immunogenic versus tolerogenic phagocytosis during anticancer therapy: mechanisms and clinical translation by Garg, A D, Romano, E, Rufo, N, Agostinis, P

“…Phagocytosis of dying cells is a major homeostatic process that represents the final stage of cell death in a tissue context. Under basal conditions, in a…”
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Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria by Wirawan, E, Vande Walle, L, Kersse, K, Cornelis, S, Claerhout, S, Vanoverberghe, I, Roelandt, R, De Rycke, R, Verspurten, J, Declercq, W, Agostinis, P, Vanden Berghe, T, Lippens, S, Vandenabeele, P

“…Autophagy and apoptosis are two important and interconnected stress-response mechanisms. However, the molecular interplay between these two pathways is not…”
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BNIP3 supports melanoma cell migration and vasculogenic mimicry by orchestrating the actin cytoskeleton by Maes, H, Van Eygen, S, Krysko, D V, Vandenabeele, P, Nys, K, Rillaerts, K, Garg, A D, Verfaillie, T, Agostinis, P

“…BNIP3 is an atypical BH3-only member of the BCL-2 family of proteins with reported pro-death as well as pro-autophagic and cytoprotective functions, depending…”
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Extracellular ATP and P2X7 receptor exert context-specific immunogenic effects after immunogenic cancer cell death by Garg, A D, Krysko, D V, Vandenabeele, P, Agostinis, P

“…Immunogenic cell death (ICD) facilitates danger signalling-driven trafficking of damage-associated molecular patterns (DAMPs) like extracellular ATP (eATP).1,2…”
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Calreticulin surface exposure is abrogated in cells lacking, chaperone-mediated autophagy-essential gene, LAMP2A by Garg, A D, Dudek, A M, Agostinis, P

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ATP13A2/PARK9 regulates endo-/lysosomal cargo sorting and proteostasis through a novel PI(3, 5)P2-mediated scaffolding function by Demirsoy, S, Martin, S, Motamedi, S, van Veen, S, Holemans, T, Van den Haute, C, Jordanova, A, Baekelandt, V, Vangheluwe, P, Agostinis, P

“…ATP13A2 (also called PARK9), is a transmembrane endo-/lysosomal-associated P5 type transport ATPase. Loss-of-function mutations in ATP13A2 result in the…”
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Cellular and molecular features related to exceptional therapy response and extreme long‐term survival in glioblastoma by Decraene, B., Vanmechelen, M., Clement, P., Daisne, J. F., Vanden Bempt, I., Sciot, R., Garg, A. D., Agostinis, P., De Smet, F., De Vleeschouwer, S.

“…Glioblastoma Multiforme (GBM) remains the most common malignant primary brain tumor with a dismal prognosis that rarely exceeds beyond 2 years despite…”
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The PERKs of damage-associated molecular patterns mediating cancer immunogenicity: From sensor to the plasma membrane and beyond by van Vliet, A.R, Martin, S, Garg, A.D, Agostinis, P

“…Abstract Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) are emerging as key adaptation mechanisms in response to loss of…”
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Concurrent MEK and autophagy inhibition is required to restore cell death associated danger-signalling in Vemurafenib-resistant melanoma cells by Martin, S., Dudek-Perić, A.M., Maes, H., Garg, A.D., Gabrysiak, M., Demirsoy, S., Swinnen, J.V., Agostinis, P.

“…Vemurafenib (PLX4032), an inhibitor of BRAFV600E, has demonstrated significant clinical anti-melanoma effects. However, the majority of treated patients…”
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Corrigendum to “Concurrent MEK and autophagy inhibition is required to restore cell death associated danger-signalling in Vemurafenib-resistant melanoma cells” [Biochem. Pharmacol. 93 (3) (2015) 290–304] by Martin, S., Dudek-Perić, A.M., Maes, H., Garg, A.D., Gabrysiak, M., Demirsoy, S., Swinnen, J.V., Agostinis, P.

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Deficiency in Apoptotic Effectors BAX and BAK Reveals an Autophagic Cell Death Pathway Initiated by Photodamage to the Endoplasmic Reticulum by Buytaert, E., Callewaert, G., Vandenheede, J.R., Agostinis, P

“…Efficient exploitation of cell death mechanisms for therapeutic purpose requires the identification of the molecular events committing cancer cells to death…”
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A deep phenotyping study in mouse and iPSC models to understand the role of oligodendroglia in optic neuropathy in Wolfram syndrome by Ahuja, K, Vandenabeele, M, Nami, F, Lefevere, E, Van Hoecke, J, Bergmans, S, Claes, M, Vervliet, T, Neyrinck, K, Burg, T, De Herdt, D, Bhaskar, P, Zhu, Y, Looser, Z J, Loncke, J, Gsell, W, Plaas, M, Agostinis, P, Swinnen, J V, Van Den Bosch, L, Bultynck, G, Saab, A S, Wolfs, E, Chai, Y C, Himmelreich, U, Verfaillie, C, Moons, L, De Groef, L

“…Wolfram syndrome (WS) is a rare childhood disease characterized by diabetes mellitus, diabetes insipidus, blindness, deafness, neurodegeneration and eventually…”
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Systems biology of immunogenic cell death in melanoma by Rufo, N, Sauter, T, Marine, J.C, Garg, A.D, Agostinis, P

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Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis by Gupta, S, Read, D E, Deepti, A, Cawley, K, Gupta, A, Oommen, D, Verfaillie, T, Matus, S, Smith, M A, Mott, J L, Agostinis, P, Hetz, C, Samali, A

“…Activation of the unfolded protein response sensor PKR-like endoplasmic reticulum kinase (Perk) attenuates endoplasmic reticulum (ER) stress levels…”
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Epithelial-mesenchymal transition during invasion of cutaneous squamous cell carcinoma is paralleled by AKT activation by Barrette, K., Van Kelst, S., Wouters, J., Marasigan, V., Fieuws, S., Agostinis, P., van den Oord, J., Garmyn, M.

“…Summary Background Epithelial–mesenchymal transition (EMT) is required for tumour invasion and dissemination to occur. Objectives To investigate EMT during…”
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Molecular effectors and modulators of hypericin-mediated cell death in bladder cancer cells by Buytaert, E, Matroule, J Y, Durinck, S, Close, P, Kocanova, S, Vandenheede, J R, de Witte, P A, Piette, J, Agostinis, P

“…Photodynamic therapy (PDT) is an anticancer approach utilizing a light-absorbing molecule and visible light irradiation to generate, in the presence of O 2 ,…”
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ATP13A2/PARK9 regulates endo-/lysosomal cargo sorting and proteostasis through a novel PI(3, 5)P2-mediated scaffolding function by Demirsoy, S., Martin, S., Motamedi, S., van Veen, S., Holemans, T., Van den Haute, C., Jordanova, A., Baekelandt, V., Vangheluwe, P., Agostinis, P.

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