Search Results - "Agnew, Heather D."

Epitope Targeting of Tertiary Protein Structure Enables Target-Guided Synthesis of a Potent In-Cell Inhibitor of Botulinum Neurotoxin by Farrow, Blake, Wong, Michelle, Malette, Jacquie, Lai, Bert, Deyle, Kaycie M., Das, Samir, Nag, Arundhati, Agnew, Heather D., Heath, James R.

“…Botulinum neurotoxin (BoNT) serotype A is the most lethal known toxin and has an occluded structure, which prevents direct inhibition of its active site before…”
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Iterative In Situ Click Chemistry Creates Antibody-like Protein-Capture Agents by Agnew, Heather D, Rohde, Rosemary D, Millward, Steven W, Nag, Arundhati, Yeo, Woon-Seok, Hein, Jason E, Pitram, Suresh M, Tariq, Abdul Ahad, Burns, Vanessa M, Krom, Russell J, Fokin, Valery V, Sharpless, K. Barry, Heath, James R

“…Special agents for protein capture: Iterative in situ click chemistry (see scheme for the tertiary ligand screen) and the one-bead-one-compound method for the…”
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A Chemically Synthesized Capture Agent Enables the Selective, Sensitive, and Robust Electrochemical Detection of Anthrax Protective Antigen by Farrow, Blake, Hong, Sung A, Romero, Errika C, Lai, Bert, Coppock, Matthew B, Deyle, Kaycie M, Finch, Amethist S, Stratis-Cullum, Dimitra N, Agnew, Heather D, Yang, Sung, Heath, James R

“…We report on a robust and sensitive approach for detecting protective antigen (PA) exotoxin from Bacillus anthracis in complex media. A peptide-based capture…”
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Comparison of affinity tags for protein purification by Lichty, Jordan J., Malecki, Joshua L., Agnew, Heather D., Michelson-Horowitz, Daniel J., Tan, Song

“…Affinity tags are highly efficient tools for purifying proteins from crude extracts. To facilitate the selection of affinity tags for purification projects, we…”
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A Non-Oxidative Approach toward Chemically and Electrochemically Functionalizing Si(111) by Rohde, Rosemary D, Agnew, Heather D, Yeo, Woon-Seok, Bailey, Ryan C, Heath, James R

“…A general method for the non-oxidative functionalization of single-crystal silicon(111) surfaces is described. The silicon surface is fully acetylenylated…”
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Peptide−Nanowire Hybrid Materials for Selective Sensing of Small Molecules by McAlpine, Michael C, Agnew, Heather D, Rohde, Rosemary D, Blanco, Mario, Ahmad, Habib, Stuparu, Andreea D, Goddard, William A, Heath, James R

“…The development of a miniaturized sensing platform for the selective detection of chemical odorants could stimulate exciting scientific and technological…”
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Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1 by Millward, Steven W, Henning, Ryan K, Kwong, Gabriel A, Pitram, Suresh, Agnew, Heather D, Deyle, Kaycie M, Nag, Arundhati, Hein, Jason, Lee, Su Seong, Lim, Jaehong, Pfeilsticker, Jessica A, Sharpless, K. Barry, Heath, James R

“…We describe the use of iterative in situ click chemistry to design an Akt-specific branched peptide triligand that is a drop-in replacement for monoclonal…”
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Designer Reagents for Mass Spectrometry-Based Proteomics: Clickable Cross-Linkers for Elucidation of Protein Structures and Interactions by Sohn, Chang Ho, Agnew, Heather D, Lee, J. Eugene, Sweredoski, Michael J, Graham, Robert L.J, Smith, Geoffrey T, Hess, Sonja, Czerwieniec, Gregg, Loo, Joseph A, Heath, James R, Deshaies, Raymond J, Beauchamp, J. L

“…We present novel homobifunctional amine-reactive clickable cross-linkers (CXLs) for investigation of three-dimensional protein structures and protein–protein…”
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Protein-Catalyzed Capture Agents by Agnew, Heather D, Coppock, Matthew B, Idso, Matthew N, Lai, Bert T, Liang, JingXin, McCarthy-Torrens, Amy M, Warren, Carmen M, Heath, James R

“…Protein-catalyzed capture agents (PCCs) are synthetic and modular peptide-based affinity agents that are developed through the use of single-generation in situ…”
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Protein Catalyzed Capture (PCC) Agents for Antigen Targeting by Idso, Matthew N, Lai, Bert T, Agnew, Heather D, Heath, James R

“…The protein catalyzed capture agent (PCC) method is a powerful combinatorial screening strategy for discovering synthetic macrocyclic peptide ligands, called…”
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Positron Emission Tomography Tracer Design of Targeted Synthetic Peptides via 18 F-Sydnone Alkyne Cycloaddition by Narayanam, Maruthi Kumar, Lai, Bert T, Loredo, Jacquie Malette, Wilson, Jeré A, Eliasen, Anders M, LaBerge, Nicole A, Nason, Malley, Cantu, Annabelle L, Luton, Breanna K, Xu, Shili, Agnew, Heather D, Murphy, Jennifer M

“…Chemically synthesized, small peptides that bind with high affinity and specificity to CD8-expressing (CD8+) tumor-infiltrating T cells, yet retain the…”
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Epitope‐Targeted Macrocyclic Peptide Ligand with Picomolar Cooperative Binding to Interleukin‐17F by Lai, Bert T., Wilson, Jeré A., Malette Loredo, Jacquie, Pitram, Suresh M., LaBerge, Nicole A., Heath, James R., Agnew, Heather D.

“…The IL‐17 cytokine family is associated with multiple immune and autoimmune diseases and comprises important diagnostic and therapeutic targets. This work…”
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A General Synthetic Approach for Designing Epitope Targeted Macrocyclic Peptide Ligands by Das, Samir, Nag, Arundhati, Liang, JingXin, Bunck, David N., Umeda, Aiko, Farrow, Blake, Coppock, Matthew B., Sarkes, Deborah A., Finch, Amethist S., Agnew, Heather D., Pitram, Suresh, Lai, Bert, Yu, Mary Beth, Museth, A. Katrine, Deyle, Kaycie M., Lepe, Bianca, Rodriguez-Rivera, Frances P., McCarthy, Amy, Alvarez-Villalonga, Belen, Chen, Ann, Heath, John, Stratis-Cullum, Dimitra N., Heath, James R.

“…We describe a general synthetic strategy for developing high‐affinity peptide binders against specific epitopes of challenging protein biomarkers. The epitope…”
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Corrigendum: Epitope Targeting of Tertiary Protein Structure Enables Target‐Guided Synthesis of a Potent In‐Cell Inhibitor of Botulinum Neurotoxin by Farrow, Blake, Wong, Michelle, Malette, Jacquie, Lai, Bert, Deyle, Kaycie M., Das, Samir, Nag, Arundhati, Agnew, Heather D., Heath, James R.

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Correction to A Chemically Synthesized Capture Agent Enables the Selective, Sensitive, and Robust Electrochemical Detection of Anthrax Protective Antigen by Farrow, Blake, Hong, Sung A, Romero, Errika C, Lai, Bert, Coppock, Matthew B, Deyle, Kaycie M, Finch, Amethist S, Stratis-Cullum, Dimitra N, Agnew, Heather D, Yang, Sung, Heath, James R

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Protein catalyzed capture agents with tailored performance for in vitro and in vivo applications by Coppock, Matthew B., Warner, Candice R., Dorsey, Brandi, Orlicki, Joshua A., Sarkes, Deborah A., Lai, Bert T., Pitram, Suresh M., Rohde, Rosemary D., Malette, Jacquie, Wilson, Jeré A., Kearney, Paul, Fang, Kenneth C., Law, Scott M., Candelario, Sherri L., Farrow, Blake, Finch, Amethist S., Agnew, Heather D., Heath, James R., Stratis‐Cullum, Dimitra N.

“…We report on peptide‐based ligands matured through the protein catalyzed capture (PCC) agent method to tailor molecular binders for in vitro…”
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In situ click chemistry: from small molecule discovery to synthetic antibodies by Millward, Steven W, Agnew, Heather D, Lai, Bert, Lee, Su Seong, Lim, Jaehong, Nag, Arundhati, Pitram, Suresh, Rohde, Rosemary, Heath, James R

“…Advances in the fields of proteomics, molecular imaging, and therapeutics are closely linked to the availability of affinity reagents that selectively…”
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Accurate MALDI-TOF/TOF Sequencing of One-Bead−One-Compound Peptide Libraries with Application to the Identification of Multiligand Protein Affinity Agents Using in Situ Click Chemistry Screening by Lee, Su Seong, Lim, Jaehong, Tan, Sylvia, Cha, Junhoe, Yeo, Shi Yun, Agnew, Heather D, Heath, James R

“…Combinatorial one-bead−one-compound (OBOC) peptide libraries are widely used for affinity screening, and the sequencing of peptides from hit beads is a key…”
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Berichtigung: Epitope Targeting of Tertiary Protein Structure Enables Target‐Guided Synthesis of a Potent In‐Cell Inhibitor of Botulinum Neurotoxin by Farrow, Blake, Wong, Michelle, Malette, Jacquie, Lai, Bert, Deyle, Kaycie M., Das, Samir, Nag, Arundhati, Agnew, Heather D., Heath, James R.

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Epitope Targeting of Tertiary Protein Structure Enables Target-Guided Synthesis of a Potent In-Cell Inhibitor of Botulinum Neurotoxin by Farrow, Blake, Wong, Michelle, Malette, Jacquie, Lai, Bert, Deyle, Kaycie M., Das, Samir, Nag, Arundhati, Agnew, Heather D., Heath, James R.

“…Botulinum neurotoxin (BoNT) serotype A is the most lethal known toxin and has an occluded structure, which prevents direct inhibition of its active site before…”
Get full text