Search Results - "Agius, P."

Molecular bottlebrush prodrugs as mono- and triplex combination therapies for multiple myeloma by Detappe, Alexandre, Nguyen, Hung V.-T., Jiang, Yivan, Agius, Michael P., Wang, Wencong, Mathieu, Clelia, Su, Nang K., Kristufek, Samantha L., Lundberg, David J., Bhagchandani, Sachin, Ghobrial, Irene M., Ghoroghchian, P. Peter, Johnson, Jeremiah A.

“…Cancer therapies often have narrow therapeutic indexes and involve potentially suboptimal combinations due to the dissimilar physical properties of drug…”
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Negative Poisson’s ratios in tendons: An unexpected mechanical response by Gatt, Ruben, Vella Wood, Michelle, Gatt, Alfred, Zarb, Francis, Formosa, Cynthia, Azzopardi, Keith M., Casha, Aaron, Agius, Tonio P., Schembri-Wismayer, Pierre, Attard, Lucienne, Chockalingam, Nachiappan, Grima, Joseph N.

“…[Display omitted] Tendons are visco-elastic structures that connect bones to muscles and perform the basic function of force transfer to and from the skeleton…”
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Resumption of injecting drug use following release from prison in Australia by Winter, R.J, Young, J.T, Stoové, M, Agius, P.A, Hellard, M.E, Kinner, S.A

“…Highlights • 41% of 533 ex-prisoners with IDU history resumed IDU over 6 months after prison. • The highest incidence of IDU resumption occurred within 1 month…”
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Factors predictive of patient outcome following total wrist arthrodesis by Owen, D H, Agius, P A, Nair, A, Perriman, D M, Smith, P N, Roberts, C J

“…Total wrist arthrodesis (TWA) produces a spectrum of outcomes. We investigated this by reviewing 77 consecutive TWA performed for inflammatory and…”
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Repeat participation in annual cross-sectional surveys of drug users and its implications for analysis by Agius, P A, Aitken, C K, Breen, C, Dietze, P M

“…We sought to establish the extent of repeat participation in a large annual cross-sectional survey of people who inject drugs and assess its implications for…”
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The effects of needle-sharing and opioid substitution therapy on incidence of hepatitis C virus infection and reinfection in people who inject drugs by AITKEN, C. K., AGIUS, P. A., HIGGS, P. G., STOOVÉ, M. A., BOWDEN, D. S., DIETZE, P. M.

“…Although high hepatitis C virus (HCV) prevalence has been observed in people who inject drugs (PWID) for decades, research suggests incidence is falling. We…”
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Community-based provision of direct-acting antiviral therapy for hepatitis C: study protocol and challenges of a randomized controlled trial by Wade, A J, Doyle, J S, Gane, E, Stedman, C, Draper, B, Iser, D, Roberts, S K, Kemp, W, Petrie, D, Scott, N, Higgs, P, Agius, P A, Roney, J, Stothers, L, Thompson, A J, Hellard, M E

“…To achieve the World Health Organization hepatitis C virus (HCV) elimination targets, it is essential to increase access to treatment. Direct-acting antiviral…”
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The Kinematics of Fixed-Seat Rowing: A Structured Synthesis by Agius, Tonio P, Cerasola, Dario, Gauci, Michael, Sciriha, Anabel, Sillato, Darren, Formosa, Cynthia, Gatt, Alfred, Xerri de Caro, John, Needham, Robert, Chockalingam, Nachiappan, Grima, Joseph N

“…Olympic-style sliding-seat rowing is a sport that has been extensively researched, with studies investigating aspects related to the physiology, biomechanics,…”
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On the Kinematics of the Forward-Facing Venetian-Style Rowing Technique by Grima, Joseph N, Cerasola, Dario, Sciriha, Anabel, Sillato, Darren, Formosa, Cynthia, Gatt, Alfred, Gauci, Michael, Xerri de Caro, John, Needham, Robert, Chockalingam, Nachiappan, Agius, Tonio P

“…This work presents a qualitative and quantitative pilot study which explores the kinematics of Venetian style forward-facing standing rowing as practised by…”
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Anorectal swabs as a marker of male-to-male sexual exposure in STI surveillance systems by AMPT, F. H., EL HAYEK, C., AGIUS, P. A., BOWRING, A. L., BARTNIK, N., VAN GEMERT, C., FAIRLEY, C. K., CHOW, E. P. F., BRADSHAW, C. S., STEPHENS, N., LIM, M. S. C., HELLARD, M. E.

“…Identification of priority populations such as men who have sex with men (MSM) is important in surveillance systems to monitor trends of sexually transmitted…”
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Spatial and temporal effects of pre-seeding plates with invasive ascidians: Growth, recruitment and community composition by Agius, Brad P.

“…Many shallow water subtidal habitats in Massachusetts, USA have recently been invaded by five non-indigenous ascidian species: Ascidiella aspersa, Botrylloides…”
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Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development by Donovan, Katherine A., Ferguson, Fleur M., Bushman, Jonathan W., Eleuteri, Nicholas A., Bhunia, Debabrata, Ryu, SeongShick, Tan, Li, Shi, Kun, Yue, Hong, Liu, Xiaoxi, Dobrovolsky, Dennis, Jiang, Baishan, Wang, Jinhua, Hao, Mingfeng, You, Inchul, Teng, Mingxing, Liang, Yanke, Hatcher, John, Li, Zhengnian, Manz, Theresa D., Groendyke, Brian, Hu, Wanyi, Nam, Yunju, Sengupta, Sandip, Cho, Hanna, Shin, Injae, Agius, Michael P., Ghobrial, Irene M., Ma, Michelle W., Che, Jianwei, Buhrlage, Sara J., Sim, Taebo, Gray, Nathanael S., Fischer, Eric S.

“…Targeted protein degradation (TPD) refers to the use of small molecules to induce ubiquitin-dependent degradation of proteins. TPD is of interest in drug…”
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Unexplained differences in sex ratios at birth in Europe and North America by Grech, Victor, Savona-Ventura, Charles, Vassallo-Agius, P

“…Significantly more boys were born in southern countries (table) than in central Europe (chi^sup 2^=57, P < 0.0001) or the Nordic countries (chi^sup 2^=8.8,…”
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Utilizing Muscle Energy Techniques for Biomechanical Changes in Chronic Obstructive Pulmonary Disease: Variations in Outcomes Based on Global Initiative for Chronic Obstructive Lung Disease Classification by Agius, Tonio P, Sevasta, Kimberley, Sciriha, Anabel

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Secular trends in sex ratios at birth in North America and Europe over the second half of the 20th century by Grech, V, Vassallo-Agius, P, Savona-Ventura, C

“…Context: A previous study showed that significantly more boys were born in southern latitudes in Europe than in northern latitudes and the converse pattern was…”
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X‑ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases by Báez-Santos, Yahira M, Barraza, Scott J, Wilson, Michael W, Agius, Michael P, Mielech, Anna M, Davis, Nicole M, Baker, Susan C, Larsen, Scott D, Mesecar, Andrew D

“…Structure-guided design was used to generate a series of noncovalent inhibitors with nanomolar potency against the papain-like protease (PLpro) from the SARS…”
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Familial disseminated atypical mycobacterial infection in childhood: a human mycobacterial susceptibility gene? by Levin, M, Newport, M J, D'Souza, S, Kalabalikis, P, Brown, I N, Lenicker, H M, Agius, P V, Davies, E G, Thrasher, A, Klein, N

“…Inherited defects in specific components of the immune system have provided many clues to the immunological mechanisms underlying resistance to microbial…”
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Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma by Zavidij, Oksana, Haradhvala, Nicholas J, Mouhieddine, Tarek H, Sklavenitis-Pistofidis, Romanos, Cai, Songjie, Reidy, Mairead, Rahmat, Mahshid, Flaifel, Abdallah, Ferland, Benjamin, Su, Nang K, Agius, Michael P, Park, Jihye, Manier, Salomon, Bustoros, Mark, Huynh, Daisy, Capelletti, Marzia, Berrios, Brianna, Liu, Chia-Jen, He, Meng Xiao, Braggio, Esteban, Fonseca, Rafael, Maruvka, Yosef E, Guerriero, Jennifer L, Goldman, Melissa, Van Allen, Eliezer M, McCarroll, Steven A, Azzi, Jamil, Getz, Gad, Ghobrial, Irene M

“…Precursor states of Multiple Myeloma (MM) and its native tumor microenvironment need in-depth molecular characterization to better stratify and treat patients…”
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Conformation-tunable ATP-competitive kinase inhibitors by Agius, Michael P, Ko, Kristin, Johnson, Taylor K, Phadke, Sameer, Soellner, Matthew B

“…Small molecule kinase inhibitors have shown immense clinical utility for diverse indications. While >60 kinase inhibitors have been approved (and many more in…”
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Synergy and Antagonism between Allosteric and Active‐Site Inhibitors of Abl Tyrosine Kinase by Johnson, Taylor K., Bochar, Daniel A., Vandecan, Nathalie M., Furtado, Jessica, Agius, Michael P., Phadke, Sameer, Soellner, Matthew B.

“…Allosteric inhibitors of Abl kinase are being explored in the clinic, often in combination with ATP‐site inhibitors of Abl kinase. However, there are…”
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