Search Results - "Aging (Albany, NY.)"

Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis by Wang, Bolin, Li, Ruobao, Lu, Zhong, Huang, Yan

“…Currently, the number of patients with coronavirus disease 2019 (COVID-19) has increased rapidly, but relationship between comorbidity and patients with…”
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Why does COVID-19 disproportionately affect older people? by Mueller, Amber L, McNamara, Maeve S, Sinclair, David A

“…The severity and outcome of coronavirus disease 2019 (COVID-19) largely depends on a patient's age. Adults over 65 years of age represent 80% of…”
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DNA methylation GrimAge strongly predicts lifespan and healthspan by Lu, Ake T, Quach, Austin, Wilson, James G, Reiner, Alex P, Aviv, Abraham, Raj, Kenneth, Hou, Lifang, Baccarelli, Andrea A, Li, Yun, Stewart, James D, Whitsel, Eric A, Assimes, Themistocles L, Ferrucci, Luigi, Horvath, Steve

“…It was unknown whether plasma protein levels can be estimated based on DNA methylation (DNAm) levels, and if so, how the resulting surrogates can be…”
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An epigenetic biomarker of aging for lifespan and healthspan by Levine, Morgan E, Lu, Ake T, Quach, Austin, Chen, Brian H, Assimes, Themistocles L, Bandinelli, Stefania, Hou, Lifang, Baccarelli, Andrea A, Stewart, James D, Li, Yun, Whitsel, Eric A, Wilson, James G, Reiner, Alex P, Aviv, Abraham, Lohman, Kurt, Liu, Yongmei, Ferrucci, Luigi, Horvath, Steve

“…Identifying reliable biomarkers of aging is a major goal in geroscience. While the first generation of epigenetic biomarkers of aging were developed using…”
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Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1 by Dong, Hui, Qiang, Zhuanzhuan, Chai, Dongdong, Peng, Jiali, Xia, Yangyang, Hu, Rong, Jiang, Hong

“…Acute lung injury (ALI) is a syndrome associated with a high mortality rate. Nrf2 is a key regulator of intracellular oxidation homeostasis that plays a…”
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Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysis by Fang, Xiaoyu, Li, Shen, Yu, Hao, Wang, Penghao, Zhang, Yao, Chen, Zheng, Li, Yang, Cheng, Liqing, Li, Wenbin, Jia, Hong, Ma, Xiangyu

“…A systematic review and meta-analysis was conducted in an attempt to systematically collect and evaluate the associations of epidemiological, comorbidity…”
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Global, regional, and national prevalence and disability-adjusted life-years for infertility in 195 countries and territories, 1990-2017: results from a global burden of disease study, 2017 by Sun, Hui, Gong, Ting-Ting, Jiang, Yu-Ting, Zhang, Shuang, Zhao, Yu-Hong, Wu, Qi-Jun

“…To provide comprehensive estimates of the global, regional, and national burden of infertility from 1990 to 2017, using findings from a 2017 study on the…”
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New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary by Schmauck-Medina, Tomas, Molière, Adrian, Lautrup, Sofie, Zhang, Jianying, Chlopicki, Stefan, Madsen, Helena Borland, Cao, Shuqin, Soendenbroe, Casper, Mansell, Els, Vestergaard, Mark Bitsch, Li, Zhiquan, Shiloh, Yosef, Opresko, Patricia L., Egly, Jean-Marc, Kirkwood, Thomas, Verdin, Eric, Bohr, Vilhelm A., Cox, Lynne S., Stevnsner, Tinna, Rasmussen, Lene Juel, Fang, Evandro F.

“…Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular…”
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Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies by Horvath, Steve, Oshima, Junko, Martin, George M, Lu, Ake T, Quach, Austin, Cohen, Howard, Felton, Sarah, Matsuyama, Mieko, Lowe, Donna, Kabacik, Sylwia, Wilson, James G, Reiner, Alex P, Maierhofer, Anna, Flunkert, Julia, Aviv, Abraham, Hou, Lifang, Baccarelli, Andrea A, Li, Yun, Stewart, James D, Whitsel, Eric A, Ferrucci, Luigi, Matsuyama, Shigemi, Raj, Kenneth

“…DNA methylation (DNAm)-based biomarkers of aging have been developed for many tissues and organs. However, these biomarkers have sub-optimal accuracy in…”
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Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies by Pistritto, Giuseppa, Trisciuoglio, Daniela, Ceci, Claudia, Garufi, Alessia, D'Orazi, Gabriella

“…Apoptosis is a form of programmed cell death that results in the orderly and efficient removal of damaged cells, such as those resulting from DNA damage or…”
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ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy by Asselta, Rosanna, Paraboschi, Elvezia Maria, Mantovani, Alberto, Duga, Stefano

“…As the outbreak of coronavirus disease 2019 (COVID-19) progresses, prognostic markers for early identification of high-risk individuals are an urgent medical…”
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DNA methylation-based measures of biological age: meta-analysis predicting time to death by Chen, Brian H, Marioni, Riccardo E, Colicino, Elena, Peters, Marjolein J, Ward-Caviness, Cavin K, Tsai, Pei-Chien, Roetker, Nicholas S, Just, Allan C, Demerath, Ellen W, Guan, Weihua, Bressler, Jan, Fornage, Myriam, Studenski, Stephanie, Vandiver, Amy R, Moore, Ann Zenobia, Tanaka, Toshiko, Kiel, Douglas P, Liang, Liming, Vokonas, Pantel, Schwartz, Joel, Lunetta, Kathryn L, Murabito, Joanne M, Bandinelli, Stefania, Hernandez, Dena G, Melzer, David, Nalls, Michael, Pilling, Luke C, Price, Timothy R, Singleton, Andrew B, Gieger, Christian, Holle, Rolf, Kretschmer, Anja, Kronenberg, Florian, Kunze, Sonja, Linseisen, Jakob, Meisinger, Christine, Rathmann, Wolfgang, Waldenberger, Melanie, Visscher, Peter M, Shah, Sonia, Wray, Naomi R, McRae, Allan F, Franco, Oscar H, Hofman, Albert, Uitterlinden, André G, Absher, Devin, Assimes, Themistocles, Levine, Morgan E, Lu, Ake T, Tsao, Philip S, Hou, Lifang, Manson, JoAnn E, Carty, Cara L, LaCroix, Andrea Z, Reiner, Alexander P, Spector, Tim D, Feinberg, Andrew P, Levy, Daniel, Baccarelli, Andrea, van Meurs, Joyce, Bell, Jordana T, Peters, Annette, Deary, Ian J, Pankow, James S, Ferrucci, Luigi, Horvath, Steve

“…Estimates of biological age based on DNA methylation patterns, often referred to as "epigenetic age", "DNAm age", have been shown to be robust biomarkers of…”
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Epigenetic clock analysis of diet, exercise, education, and lifestyle factors by Quach, Austin, Levine, Morgan E, Tanaka, Toshiko, Lu, Ake T, Chen, Brian H, Ferrucci, Luigi, Ritz, Beate, Bandinelli, Stefania, Neuhouser, Marian L, Beasley, Jeannette M, Snetselaar, Linda, Wallace, Robert B, Tsao, Philip S, Absher, Devin, Assimes, Themistocles L, Stewart, James D, Li, Yun, Hou, Lifang, Baccarelli, Andrea A, Whitsel, Eric A, Horvath, Steve

“…Behavioral and lifestyle factors have been shown to relate to a number of health-related outcomes, yet there is a need for studies that examine their…”
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New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463 by Zhu, Yi, Doornebal, Ewald J., Pirtskhalava, Tamar, Giorgadze, Nino, Wentworth, Mark, Fuhrmann-Stroissnigg, Heike, Niedernhofer, Laura J., Robbins, Paul D., Tchkonia, Tamara, Kirkland, James L.

“…Senescent cells accumulate with aging and at sites of pathology in multiple chronic diseases. Senolytics are drugs that selectively promote apoptosis of…”
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New agents that target senescent cells: the flavone, fisetin, and the BCL-X L inhibitors, A1331852 and A1155463 by Zhu, Yi, Doornebal, Ewald J, Pirtskhalava, Tamar, Giorgadze, Nino, Wentworth, Mark, Fuhrmann-Stroissnigg, Heike, Niedernhofer, Laura J, Robbins, Paul D, Tchkonia, Tamara, Kirkland, James L

“…Senescent cells accumulate with aging and at sites of pathology in multiple chronic diseases. Senolytics are drugs that selectively promote apoptosis of…”
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Metformin protects against myocardial ischemia-reperfusion injury and cell pyroptosis via AMPK/NLRP3 inflammasome pathway by Zhang, Jing, Huang, Lelin, Shi, Xing, Yang, Liu, Hua, Fuzhou, Ma, Jianyong, Zhu, Wengen, Liu, Xiao, Xuan, Rui, Shen, Yunfeng, Liu, Jianping, Lai, Xiaoyang, Yu, Peng

“…Ischemia/reperfusion (I/R) injury is a life-threatening vascular emergency following myocardial infarction. Our previous study showed cardioprotective effects…”
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DNA methylation-based estimator of telomere length by Lu, Ake T, Seeboth, Anne, Tsai, Pei-Chien, Sun, Dianjianyi, Quach, Austin, Reiner, Alex P, Kooperberg, Charles, Ferrucci, Luigi, Hou, Lifang, Baccarelli, Andrea A, Li, Yun, Harris, Sarah E, Corley, Janie, Taylor, Adele, Deary, Ian J, Stewart, James D, Whitsel, Eric A, Assimes, Themistocles L, Chen, Wei, Li, Shengxu, Mangino, Massimo, Bell, Jordana T, Wilson, James G, Aviv, Abraham, Marioni, Riccardo E, Raj, Kenneth, Horvath, Steve

“…Telomere length (TL) is associated with several aging-related diseases. Here, we present a DNA methylation estimator of TL (DNAmTL) based on 140 CpGs…”
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LncRNA MALAT1 shuttled by bone marrow-derived mesenchymal stem cells-secreted exosomes alleviates osteoporosis through mediating microRNA-34c/SATB2 axis by Yang, Xucheng, Yang, Junxiao, Lei, Pengfei, Wen, Ting

“…Long non-coding RNAs (lncRNAs) have emerged as promising novel modulators during osteogenesis in mesenchymal stem cells (MSCs). Enhanced SATB2 has been…”
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Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial by Fitzgerald, Kara N, Hodges, Romilly, Hanes, Douglas, Stack, Emily, Cheishvili, David, Szyf, Moshe, Henkel, Janine, Twedt, Melissa W, Giannopoulou, Despina, Herdell, Josette, Logan, Sally, Bradley, Ryan

“…Manipulations to slow biological aging and extend healthspan are of interest given the societal and healthcare costs of our aging population. Herein we report…”
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Gut microbiota and metabolite alterations associated with reduced bone mineral density or bone metabolic indexes in postmenopausal osteoporosis by He, Jianquan, Xu, Shuangbin, Zhang, Bangzhou, Xiao, Chuanxing, Chen, Zhangran, Si, Fuyou, Fu, Jifan, Lin, Xiaomei, Zheng, Guohua, Yu, Guangchuang, Chen, Jian

“…Reduced bone mineral density (BMD) is associated with an altered microbiota in senile osteoporosis. However, the relationship among gut microbiota, BMD and…”
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