The efficacy of zinc augmentation in children with attention deficit hyperactivity disorder under treatment with methylphenidate: A randomized controlled trial

Regarding to the role of the zinc in the metabolism of the central nervous system and the correlation of zinc supplementation in the treatment of any Attention deficit hyperactivity disorder (ADHD) symptoms, this study was conducted to evaluate the complementary effects of this nutrient. This was a...

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Bibliographic Details
Published in:	Asian journal of psychiatry Vol. 48; p. 101868
Main Authors:	Noorazar, Seyyed Gholamreza, Malek, Ayyoub, Aghaei, Sima Mir, Yasamineh, Neda, Kalejahi, Parinaz
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-02-2020
Subjects:	Attention Deficit Disorder with Hyperactivity Attention deficit hyperactivity disorder Augmentation Central Nervous System Stimulants - administration & dosage Central Nervous System Stimulants - pharmacology Child Connors questionnaire Double-Blind Method Drug Therapy, Combination Female Humans Male Methylphenidate Methylphenidate - administration & dosage Methylphenidate - pharmacology Trace Elements - administration & dosage Trace Elements - pharmacology Treatment Outcome Zinc Zinc - administration & dosage Zinc - pharmacology Augmentation Attention deficit hyperactivity disorder Zinc Methylphenidate Connors questionnaire
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Summary:	Regarding to the role of the zinc in the metabolism of the central nervous system and the correlation of zinc supplementation in the treatment of any Attention deficit hyperactivity disorder (ADHD) symptoms, this study was conducted to evaluate the complementary effects of this nutrient. This was a double-blind randomized clinical trial study and 60 children with ADHD who were treated with methylphenidate were chosen by random allocation and were divided in the two groups: 30 for the case and 30 for the control group. The treatment in case group was augmented with zinc. Duration of study was six weeks. Forty eight (80%) of participants were boy and 12 (20%) were girl. The mean age of patients was 9.6 ± 1.70 years. There was no significant difference between the two groups after the intervention in terms of total score, hyperactivity and impulsivity subscales during variance analysis, but there was a significant difference between the mean of inattention score. Augmentation with zinc can enhance the improvement of inattention.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23
ISSN:	1876-2018 1876-2026
DOI:	10.1016/j.ajp.2019.101868