Novel 4-(4-substituted-thiazol-2-ylamino)-N-(pyridin-2-yl)-benzenesulfonamides as cytotoxic and radiosensitizing agents

A series of novel 4-(4-substituted-thiazol-2-ylamino)-N-(pyridin-2-yl) benzene-sulfonamides were synthesized and screened for their cytotoxic activity against human breast cancer cell line (MCF-7). Compounds 6, 7, 9, 10, 11 , and 14 displayed significant activity against MCF-7 when compared to doxor...

Full description

Saved in:

Bibliographic Details
Published in:	Archives of pharmacal research Vol. 35; no. 1; pp. 59 - 68
Main Authors:	Ghorab, Mostafa M., Ragab, Fatma A., Heiba, Helmy I., Agha, Hebaallah M., Nissan, Yassin M.
Format:	Journal Article
Language:	English
Published:	Heidelberg Pharmaceutical Society of Korea 2012 대한약학회
Subjects:	Benzenesulfonamides Binding Sites Cell Line, Tumor Crystallography, X-Ray Cytotoxins - chemistry Cytotoxins - pharmacology Doxorubicin - pharmacology Drug Screening Assays, Antitumor Humans Medicine Pharmacology/Toxicology Pharmacy Protein Structure, Secondary Radiation-Sensitizing Agents - chemistry Radiation-Sensitizing Agents - pharmacology Research Article Sulfonamides - chemistry Sulfonamides - pharmacology 약학 Radiosensetizing activities Cytotoxic Sulfonamides Thiazoles
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	A series of novel 4-(4-substituted-thiazol-2-ylamino)-N-(pyridin-2-yl) benzene-sulfonamides were synthesized and screened for their cytotoxic activity against human breast cancer cell line (MCF-7). Compounds 6, 7, 9, 10, 11 , and 14 displayed significant activity against MCF-7 when compared to doxorubicin, which was used as a reference drug. The synergistic effect of Gamma radiation for the most active derivatives 7, 9 , and 11 was also studied and their IC 50 values markedly decreased to 11.9 μM, 11.7 μM, and 11.6 μM, respectively.
Bibliography:	G704-000010.2012.35.1.019
ISSN:	0253-6269 1976-3786
DOI:	10.1007/s12272-012-0106-y