Search Results - "Aggen, James"

Synthesis and Spectrum of the Neoglycoside ACHN-490 by AGGEN, James B, ARMSTRONG, Eliana S, LOPEZ, Sara, GOMEZ, Marcela, WLASICHUK, Kenneth B, DIOKNO, Raymond, MILLER, George H, MOSER, Heinz E, GOLDBLUM, Adam A, DOZZO, Paola, LINSELL, Martin S, GLIEDT, Micah J, HILDEBRANDT, Darin J, FEENEY, Lee Ann, KUBO, Aya, MATIAS, Rowena D

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Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors by Burnett, G. Leslie, Yang, Yu C., Aggen, James B., Pitzen, Jennifer, Gliedt, Micah K., Semko, Chris M., Marquez, Abby, Evans, James W., Wang, Gang, Won, Walter S., Tomlinson, Aidan C. A., Kiss, Gert, Tzitzilonis, Christos, Thottumkara, Arun P., Cregg, James, Mellem, Kevin T., Choi, Jong S., Lee, Julie C., Zhao, Yongyuan, Lee, Bianca J., Meyerowitz, Justin G., Knox, John E., Jiang, Jingjing, Wang, Zhican, Wildes, David, Wang, Zhengping, Singh, Mallika, Smith, Jacqueline A. M., Gill, Adrian L.

“…Hyperactivation of mTOR kinase by mutations in the PI3K/mTOR pathway or by crosstalk with other mutant cancer drivers, such as RAS, is a feature of many…”
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Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth by Lee, Bianca J., Boyer, Jacob A., Burnett, G. Leslie, Thottumkara, Arun P., Tibrewal, Nidhi, Wilson, Stacy L., Hsieh, Tientien, Marquez, Abby, Lorenzana, Edward G., Evans, James W., Hulea, Laura, Kiss, Gert, Liu, Hui, Lee, Dong, Larsson, Ola, McLaughlan, Shannon, Topisirovic, Ivan, Wang, Zhengping, Wang, Zhican, Zhao, Yongyuan, Wildes, David, Aggen, James B., Singh, Mallika, Gill, Adrian L., Smith, Jacqueline A. M., Rosen, Neal

“…The clinical benefits of pan-mTOR active-site inhibitors are limited by toxicity and relief of feedback inhibition of receptor expression. To address these…”
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ACHN-490, a Neoglycoside with Potent In Vitro Activity against Multidrug-Resistant Klebsiella pneumoniae Isolates by ENDIMIANI, Andrea, HUJER, Kristine M, HUJER, Andrea M, ARMSTRONG, Eliana S, CHOUDHARY, Yuvraj, AGGEN, James B, BONOMO, Robert A

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Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety by Cohen, Frederick, Aggen, James B., Andrews, Logan D., Assar, Zahra, Boggs, Jen, Choi, Taylor, Dozzo, Paola, Easterday, Ashton N., Haglund, Cat M., Hildebrandt, Darin J., Holt, Melissa C., Joly, Kristin, Jubb, Adrian, Kamal, Zeeshan, Kane, Timothy R., Konradi, Andrei W., Krause, Kevin M., Linsell, Martin S., Machajewski, Timothy D., Miroshnikova, Olga, Moser, Heinz E., Nieto, Vincent, Phan, Thu, Plato, Craig, Serio, Alisa W., Seroogy, Julie, Shakhmin, Anton, Stein, Adam J., Sun, Alex D., Sviridov, Serguei, Wang, Zhan, Wlasichuk, Kenneth, Yang, Wen, Zhou, Xiaoming, Zhu, Hai, Cirz, Ryan T.

“…UDP‐3‐O‐(R‐3‐hydroxymyristoyl)‐N‐acetylglucosamine deacetylase (LpxC) is a Zn2+ deacetylase that is essential for the survival of most pathogenic Gram‐negative…”
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In Vivo Efficacy of the Novel Aminoglycoside ACHN-490 in Murine Infection Models by Reyes, Noe, Aggen, James B, Kostrub, Corwin F

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Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth by Lee, Bianca J., Boyer, Jacob A., Burnett, G. Leslie, Thottumkara, Arun P., Tibrewal, Nidhi, Wilson, Stacy L., Hsieh, Tientien, Marquez, Abby, Lorenzana, Edward G., Evans, James W., Hulea, Laura, Kiss, Gert, Liu, Hui, Lee, Dong, Larsson, Ola, McLaughlan, Shannon, Topisirovic, Ivan, Wang, Zhengping, Wang, Zhican, Zhao, Yongyuan, Wildes, David, Aggen, James B., Singh, Mallika, Gill, Adrian L., Smith, Jacqueline A. M., Rosen, Neal

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Compound design guidelines for evading the efflux and permeation barriers of Escherichia coli with the oxazolidinone class of antibacterials: Test case for a general approach to improving whole cell Gram-negative activity by Spaulding, Andrew, Takrouri, Khuloud, Mahalingam, Pornachandran, Cleary, Dillon C., Cooper, Harold D., Zucchi, Paola, Tear, Westley, Koleva, Bilyana, Beuning, Penny J., Hirsch, Elizabeth B., Aggen, James B.

“…[Display omitted] Previously we reported the results from an effort to improve Gram-negative antibacterial activity in the oxazolidinone class of antibiotics…”
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Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth by Lee, Bianca J., Boyer, Jacob A., Burnett, G. Leslie, Thottumkara, Arun P., Tibrewal, Nidhi, Wilson, Stacy L., Hsieh, Tientien, Marquez, Abby, Lorenzana, Edward G., Evans, James W., Hulea, Laura, Kiss, Gert, Liu, Hui, Lee, Dong, Larsson, Ola, McLaughlan, Shannon, Topisirovic, Ivan, Wang, Zhengping, Wang, Zhican, Zhao, Yongyuan, Wildes, David, Aggen, James B., Singh, Mallika, Gill, Adrian L., Smith, Jacqueline A. M., Rosen, Neal

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Toxicity Modulation, Resistance Enzyme Evasion, and A‑Site X‑ray Structure of Broad-Spectrum Antibacterial Neomycin Analogs by Maianti, Juan Pablo, Kanazawa, Hiroki, Dozzo, Paola, Matias, Rowena D, Feeney, Lee Ann, Armstrong, Eliana S, Hildebrandt, Darin J, Kane, Timothy R, Gliedt, Micah J, Goldblum, Adam A, Linsell, Martin S, Aggen, James B, Kondo, Jiro, Hanessian, Stephen

“…Aminoglycoside antibiotics are pseudosaccharides decorated with ammonium groups that are critical for their potent broad-spectrum antibacterial activity…”
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Progress against Escherichia coli with the Oxazolidinone Class of Antibacterials: Test Case for a General Approach To Improving Whole-Cell Gram-Negative Activity by Takrouri, Khuloud, Cooper, Harold D, Spaulding, Andrew, Zucchi, Paola, Koleva, Bilyana, Cleary, Dillon C, Tear, Westley, Beuning, Penny J, Hirsch, Elizabeth B, Aggen, James B

“…Novel antibacterials with activity against the Gram-negative bacteria associated with nosocomial infections, including Escherichia coli and other…”
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1-(4-Phenylpiperazin-1-yl)-2-(1H-pyrazol-1-yl)ethanones as novel CCR1 antagonists by Pennell, Andrew M.K., Aggen, James B., Sen, Subhabrata, Chen, Wei, Xu, Yuan, Sullivan, Edward, Li, Lianfa, Greenman, Kevin, Charvat, Trevor, Hansen, Derek, Dairaghi, Daniel J., Wright, J.J. Kim, Zhang, Penglie

“…A novel series of CCR1 antagonists based on the 1-(4-phenylpiperazin-1-yl)-2-(1H-pyrazol-1-yl)ethanone scaffold was identified by screening a compound library…”
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Congener-Independent Immunoassay for Microcystins and Nodularins by Fischer, Werner J, Garthwaite, Ian, Miles, Christopher O, Ross, Kathryn M, Aggen, James B, Chamberlin, A. Richard, Towers, Neale R, Dietrich, Daniel R

“…Cyanobacteria (blue-green algae) (e.g., Microcystis and Nodularia spp.) capable of producing toxic peptides are found in fresh and brackish water worldwide…”
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Multivalent design of long-acting β(2)-adrenoceptor agonists incorporating biarylamines by Jacobsen, John R, Aggen, James B, Church, Timothy J, Klein, Uwe, Pfeiffer, Juergen W, Pulido-Rios, Teresa M, Thomas, G Roger, Yu, Cecile, Moran, Edmund J

“…A series of potent β2-adrenoceptor agonists incorporating a biarylamine secondary binding group was identified. The previously reported milveterol (5),…”
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Exploring the Positional Attachment of Glycopeptide/β-lactam Heterodimers by Long, Daniel D, Aggen, James B, Chinn, Jason, Choi, Seok-Ki, Christensen, Burton G, Fatheree, Paul R, Green, David, Hegde, Sharath S, Judice, J Kevin, Kaniga, Koné, Krause, Kevin M, Leadbetter, Michael, Linsell, Martin S, Marquess, Daniel G, Moran, Edmund J, Nodwell, Matthew B, Pace, John L, Trapp, Sean G, Turne, S Derek

“…Further investigations towards novel glycopeptide/β-lactam heterodimers are reported. Employing a multivalent approach to drug discovery, vancomycin and…”
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A Multivalent Approach to Drug Discovery for Novel Antibiotics by Long, Daniel D, Aggen, James B, Christensen, Burton G, Judice, J Kevin, Hegde, Sharath S, Kaniga, Koné, Krause, Kevin M, Linsell, Martin S, Moran, Edmund J, Pace, John L

“…The design, synthesis and antibacterial activity of novel glycopeptide/β-lactam heterodimers is reported. Employing a multivalent approach to drug discovery,…”
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A Central Strategy for Converting Natural Products into Fluorescent Probes by Alexander, Matthew D., Burkart, Michael D., Leonard, Michael S., Portonovo, Padma, Liang, Bo, Ding, Xiaobin, Joullié, Madeleine M., Gulledge, Brian M., Aggen, James B., Chamberlin, A. Richard, Sandler, Joel, Fenical, William, Cui, Jian, Gharpure, Santosh J., Polosukhin, Alexei, Zhang, Hai-Ren, Evans, P. Andrew, Richardson, Adam D., Harper, Mary Kay, Ireland, Chris M., Vong, Binh G., Brady, Thomas P., Theodorakis, Emmanuel A., La Clair, James J.

“…A centralized method for studying natural product chemical biology begins by designating a single fluorescent dye as a core reporter and develops through the…”
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Toward Overcoming Staphylococcus aureus Aminoglycoside Resistance Mechanisms with a Functionally Designed Neomycin Analogue by Hanessian, Stephen, Giguère, Alexandre, Grzyb, Justyna, Maianti, Juan Pablo, Saavedra, Oscar M, Aggen, James B, Linsell, Martin S, Goldblum, Adam A, Hildebrandt, Darin J, Kane, Timothy R, Dozzo, Paola, Gliedt, Micah J, Matias, Rowena D, Feeney, Lee Ann, Armstrong, Eliana S

“…Deoxygenation of the diol groups in rings A and D of neomycin in combination with the introduction of an N1-(l)-HABA group in the 2-deoxystreptamine subunit…”
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Microcystin analogues comprised only of adda and a single additional amino acid retain moderate activity as PP1/PP2A inhibitors by Gulledge, Brian M, Aggen, James B, Eng, Hugo, Sweimeh, Khuloud, Chamberlin, A.Richard

“…A series of greatly simplified microcystin analogues comprised only of Adda (the β-amino acid common to the microcystins, nodularins, and motuporin,) and a…”
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Total Synthesis of the Serine-Threonine Phosphatase Inhibitor Microcystin-LA by Humphrey, John M, Aggen, James B, Chamberlin, A. Richard

“…Reversible protein phosphorylation, which is mediated by kinases and phosphatases, is a major control element of the cell. There is a diverse group of toxic…”
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