Search Results - "Aggarwal, Hobby"

Modulation of Insulin Resistance, Dyslipidemia and Serum Metabolome in iNOS Knockout Mice following Treatment with Nitrite, Metformin, Pioglitazone, and a Combination of Ampicillin and Neomycin by Aggarwal, Hobby, Pathak, Priya, Kumar, Yashwant, Jagavelu, Kumaravelu, Dikshit, Madhu

“…Oxidative and nitrosative stress plays a pivotal role in the incidence of metabolic disorders. Studies from this lab and others in iNOS mice have demonstrated…”
Get full text

Vancomycin-Induced Modulation of Gram-Positive Gut Bacteria and Metabolites Remediates Insulin Resistance in iNOS Knockout Mice by Aggarwal, Hobby, Pathak, Priya, Singh, Vishal, Kumar, Yashwant, Shankar, Manoharan, Das, Bhabatosh, Jagavelu, Kumaravelu, Dikshit, Madhu

“…The role of oxidative and nitrosative stress has been implied in both physiology and pathophysiology of metabolic disorders. Inducible nitric oxide synthase…”
Get full text

Systemic Insulin Resistance and Metabolic Perturbations in Chow Fed Inducible Nitric Oxide Synthase Knockout Male Mice: Partial Reversal by Nitrite Supplementation by Aggarwal, Hobby, Pathak, Priya, Singh, Pragati, Gayen, Jiaur R., Jagavelu, Kumaravelu, Dikshit, Madhu

“…iNOS, an important mediator of inflammation, has emerged as an important metabolic regulator. There are conflicting observations on the incidence of insulin…”
Get full text

A methionine-choline-deficient diet induces nonalcoholic steatohepatitis and alters the lipidome, metabolome, and gut microbiome profile in the C57BL/6J mouse by Gautam, Jyoti, Aggarwal, Hobby, Kumari, Deepika, Gupta, Sonu Kumar, Kumar, Yashwant, Dikshit, Madhu

“…The methionine-choline-deficient (MCD) diet-induced non-alcoholic steatohepatitis (NASH) in mice is a well-established model. Our study aims to elucidate the…”
Get full text

Improved metabolic stability in iNOS knockout mice with Lactobacillus supplementation by Aggarwal, Hobby, Gautam, Jyoti, Gupta, Sonu Kumar, Das, Bhabatosh, Kumar, Yashwant, Jagavelu, Kumaravelu, Dikshit, Madhu

“…•iNOS−/− mice exhibited reduced microbial diversity and diminished Lactobacillus.•Lactobacillus supplementation (LGG) reversed IR and dyslipidemia in iNOS−/−…”
Get full text

Comparative profiling of gut microbiota and metabolome in diet-induced obese and insulin-resistant C57BL/6J mice by Aggarwal, Hobby, Gautam, Jyoti, Kumari, Deepika, Gupta, Sonu Kumar, Bajpai, Sneh, Chaturvedi, Kartikey, Kumar, Yashwant, Dikshit, Madhu

“…Diet-based models are commonly used to investigate obesity and related disorders. We conducted a comparative profiling of three obesogenic diets HFD, high fat…”
Get full text

Serum and cecal metabolic profile of the insulin resistant and dyslipidemic p47 phox knockout mice by Aggarwal, Hobby, Pathak, Priya, Gupta, Sonu Kumar, Kumar, Yashwant, Jagavelu, Kumaravelu, Dikshit, Madhu

“…Involvement of NOX-dependent oxidative stress in the pathophysiology of metabolic disorders as well as in the maintenance of metabolic homeostasis has been…”
Get more information

Modulations in human neutrophil metabolome and S-glutathionylation of glycolytic pathway enzymes during the course of extracellular trap formation by Awasthi, Deepika, Nagarkoti, Sheela, Sadaf, Samreen, Aggarwal, Hobby, Gupta, Sonu Kumar, Chandra, Tulika, Kumar, Yashwant, Kumar, Sachin, Dikshit, Madhu

“…Neutrophil extracellular trap formation (NETosis) has been irrefutably referred to as a distinct and unique form of active cell death with the purpose to…”
Get more information

Characterization of lipid signatures in the plasma and insulin-sensitive tissues of the C57BL/6J mice fed on obesogenic diets by Gautam, Jyoti, Kumari, Deepika, Aggarwal, Hobby, Gupta, Sonu Kumar, Kasarla, Siva Swapna, Sarkar, Soumalya, Priya, M.R. Kamla, Kamboj, Parul, Kumar, Yashwant, Dikshit, Madhu

“…Diet-induced obesity mouse models are widely utilized to investigate the underlying mechanisms of dyslipidemia, glucose intolerance, insulin resistance,…”
Get full text

Feeding enhances fibronectin adherence of quiescent lymphocytes through non‐canonical insulin signalling by Mallu, Abhiram Charan Tej, Sivagurunathan, Sivapriya, Paul, Debasish, Aggarwal, Hobby, Nathan, Abel Arul, Manikandan, Amrutha, Ravi, Mahalakshmi M., Boppana, Ramanamurthy, Jagavelu, Kumaravelu, Santra, Manas Kumar, Dixit, Madhulika

“…Nutritional availability during fasting and refeeding affects the temporal redistribution of lymphoid and myeloid immune cells among the circulating and…”
Get full text

ForePass endoscopic bypass device for obesity and insulin resistance-metabolic treatment in a swine model by Angelini, Giulia, Galvao Neto, Manoel, Boskoski, Ivo, Caristo, Maria Emiliana, Russo, Sara, Proto, Luca, Previti, Elena, Olsson, Lisa, Aggarwal, Hobby, Pezzica, Samantha, Ferrari, Elisa, Bove, Vincenzo, Genco, Alfredo, Bornstein, Stefan, Tremaroli, Valentina, Gastaldelli, Amalia, Mingrone, Geltrude

Get more information

Vasoreactivity of isolated aortic rings from dyslipidemic and insulin resistant inducible nitric oxide synthase knockout mice by Pathak, Priya, Kanshana, Jitendra S., Kanuri, BabuNageswar, Rebello, Sanjay C., Aggarwal, Hobby, Jagavelu, Kumaravelu, Dikshit, Madhu

“…Recent study from this lab indicated enhanced susceptibility of iNOS KO mice for diet induced obesity (DIO) and systemic insulin resistance (IR) as compared to…”
Get full text

Anti-thrombotic efficacy of S007-867: Pre-clinical evaluation in experimental models of thrombosis in vivo and in vitro by Misra, Ankita, Prakash, Prem, Aggarwal, Hobby, Dhankani, Priyanka, Kumar, Sachin, Pandey, Chandra Prakash, Pugh, Nicholas, Bihan, Dominique, Barthwal, Manoj Kumar, Farndale, Richard W., Dikshit, Dinesh Kumar, Dikshit, Madhu

“…[Display omitted] Pharmacological inhibition of platelet collagen interaction is a promising therapeutic strategy to treat intra-vascular thrombosis. S007-867…”
Get full text

Standardized fraction of Xylocarpus moluccensis fruits improve vascular relaxation and plaque stability in dyslipidemic models of atherosclerosis by Kanshana, Jitendra S., Rebello, Sanjay C., Pathak, Priya, Kanuri, Babu Nageswararao, Aggarwal, Hobby, Srivastava, Vasundhara, Khanna, Vivek, Singh, Vishal, Jagavelu, Kumaravelu, Barthwal, Manoj K., Dikshit, Madhu

“…Xylocarpus moluccensis (Lamk.) M. Roem of family Meliaceae has triterpenoids rich fruits. Triterpenoids have been known to possess cardioprotection and…”
Get full text

Corrigendum to ‘Anti-thrombotic efficacy of S007-867: Pre-clinical evaluation in experimental models of thrombosis in vivo and in vitro’ [Biochem. Pharmacol. 148 (2018) 288–297] by Misra, Ankita, Prakash, Prem, Aggarwal, Hobby, Dhankani, Priyanka, Kumar, Sachin, Prakash Pandey, Chandra, Pugh, Nicholas, Bihan, Dominique, Kumar Barthwal, Manoj, Farndale, Richard W., Kumar Dikshit, Dinesh, Dikshit, Madhu

Get full text